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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Assay System and Analysis Algorithm in Detecting RNA Editing Events and Linked Splicing Isoforms

    SBC: Celetrix LLC            Topic: NIDA

    Abstract RNA editing is a process in which the genome encoded information is altered in RNA RNA editing is an efficient way to increase RNA complexity thereby fine tuning both gene function and dosage Adenosine to Inosine A to I editing is the most common type of RNA editing known in animals The cellular machinery recognizes inosine as guanosine so A to I editing of codons and splicing sign ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Optimizing Vaccines by Targeting Dendritic Cells with IFNa and IFNb Inducing Adjuvants

    SBC: PARABON NANOLABS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant There is a critical need for a safe and effective vaccine against HIV Decades of work have been invested in understanding the immune response to infection and different approaches have been taken to develop vaccines that are effective in preventing and treating the disease While effective in animal models none have been as effective in humans The immune ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. development of immunodeficient rabbit models

    SBC: Celetrix LLC            Topic: NIAID

    DESCRIPTION provided by applicant Transplantation of human or animal pluripotent stem cells PSCs or their derivatives to model animals constitutes an important preclinical system to model and investigate cell survival development and differentiation in vivo and to assess the safety and efficacy of transplantation based cell therapies Immunodeficient mice are dominantly used in biomedical ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Lab-on-a-patch for neonates to monitor real-time glucose and reduce needle pain

    SBC: ZANSORS LLC            Topic: NICHD

    DESCRIPTION provided by applicant This STTR grant is aimed to reduce pain from repeated needle pricks by improving the monitoring of glucose homeostasis GH in neonates by developing a real time glucose monitoring device The innovation utilizes a micro needle based lab on a patch platform invented by STTR partner George Washington University GWU GH is usually monitored by blood test via a ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a tool for the whole genome de novo assembly of hepatitis B virus (HBV) populations

    SBC: GATACA LLC            Topic: NIAID

    DESCRIPTION provided by applicant Hepatitis infection is a widespread and persistent crisis both in the U S and worldwide Chronic infection with the hepatitis B virus HBV is a major cause of end stage liver disease with staggering long term healthcare costs Thus HBV research and innovation have been deemed national priorities in the U S as evidenced by calls to action by the Institute ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Peptide inhibition of complement-mediated hemolysis after xenotransfusion.

    SBC: Childrens Specialty Group PLLC            Topic: NIAID

    DESCRIPTION provided by applicant The hypothesis for this project is that a novel compound Peptide Inhibitor of complement C PIC will inhibit antibody initiated complement mediated cell destruction in a xenotransfusion animal model Complement is the most potent inflammatory cascade in humans and is initiated by antibodies driving classical pathway activation and host cell destruction in ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting galectin-3 for prostate cancer therapy

    SBC: GLYCOMANTRA INC            Topic: NCI

    DESCRIPTION provided by applicant Galectin a beta galactoside binding lectin is involved in the progression of many cancers In our recent publication in PNAS PMC we have shown that in prostate cancer galectin promotes tumor angiogenesis tumor endothelial cell adhesion and metastasis and also evades immune surveillance through killing of infiltrating T cells To block galecti ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Online resource center for older adults with cochlear implants

    SBC: KDH Research & Communication, Inc.            Topic: NIDCD

    In this Phase I proposal resubmission KDH Research andamp Communication KDHRC proposes to develop and evaluate the Online Resource Center for Older Adults with Cochlear Implants RCCI RCCI will be an innovative web based resource center for older adults aged with cochlear implants CIs and their family members for age related hearing loss RCCI will provide high quality information ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Bone-Targeting Combination Therapy for Osteosarcoma

    SBC: MBC Pharma, Inc.            Topic: 102

    DESCRIPTION provided by applicant The overall aim of this project is to evaluate the feasibility of using a novel gemcitabine ibandronate conjugate alone and or as part of a combination therapy for the treatment of osteosarcoma and associated metastases The conjugate consists of chemically linked anticancer antimetabolite Gemcitabine and the bone homing bisphosphonate Ibandronate The novel co ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Transcutaneous Neuromodulation at Acupoint for Gastric Complications of Scleroderma

    SBC: TRANSTIMULATION RESEARCH INC            Topic: R

    DESCRIPTION provided by applicant Systemic sclerosis scleroderma SSc is a chronic autoimmune disease characterized by proliferative vascular lesions with resultant fibrosis of skin and other multiple organs including the gastrointestinal GI tract In the United States the prevalence of SSc is about per million in adults Up to of SSc patients are reported to have upper and lower ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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