Award Data

DESCRIPTION (provided by applicant): The NIH Roadmap recognizes the need for system-level, multidisciplinary research to successfully fight diseases such as cancer. However, collecting, integrating, and analyzing heterogeneous sets of data represent a subs tantial undertaking, both technical and managerial, that requires resources not available to most investigators. As the field continues to move ...

DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of the plague, has been weaponized as an agent of biowarfare. The deliberate release of weaponized Y. pestis would likely occur via aerosol dissemination resulting in an outbreak of the highly lethal and contagious pneumonic plague. Therefore there is a critical need for new agents to combat infection by the antibiotic-resi ...

DESCRIPTION (provided by applicant): Our specific objective with this fast-track STTR application is a diagnostic screen for the NIAID Biodefense Category B intestinal pathogens Giardia lamblia, Cryptosporidium spp., and Entamoeba histolytica in stool. The se enteric protozoa share the characteristics of food and water-borne transmission, low infectious dose, and environmental stability. E. histol ...

DESCRIPTION (provided by applicant): Linomide is a known anti-inflammatory drug. Recently we have synthesized a new analog of Linomide, linomide-5. The objective of this proposal is to develop linomide-5 as a therapeutic for treating diabetic retinopathy ( DR) and age-related macular degeneration (AMD). Together, these diseases constitute the major causes of blindness worldwide. In both cases, ret ...

DESCRIPTION (provided by applicant): In children with acute lymphomatic leukemia (ALL) and in myelodysplastic syndrome (MDS) with older patients it is extremely important to measure the minimal residual disease (MRD) to monitor the progress of chemotherapy at early stages Such measurements determine the prognosis, efficacy, and levels of the treatment. The normal method for detection and monitori ...

DESCRIPTION (provided by applicant): This two-year proposal seeks small business support for IDX Labs LLC to continue collaborating with Dr. Houpt at the University of Virginia to bring sensitive real-time PCR (qPCR) tests for Giardia and Cryptosporidium t o U.S. labs. According to the CDC, these parasites infect up to 2 million Americans annually, and we have developed robust sensitive qPCR tests ...

DESCRIPTION (provided by applicant): In this Phase II SBIR Luna Innovations will perform human subject tests of the EN-TACT(tm) Patient Monitor to determine the sensitivity and specificity of diagnosis of compartment syndrome as compared to slit-catheter m easurements of intramuscular pressure (IMP), the current gold standard measurement. A Phase I animal model showed that the EN-TACT(tm) Patient ...

DESCRIPTION (provided by applicant): This proposed project is motivated by two observations. First, broad-scale screening of diabetics for retinopathy is economically prohibitive without the introduction of computer-assisted diagnosis of retinal images. S econd, screening by family physicians or other non-ophthalmologists does not result in sufficiently high sensitivity or specificity. There are ...

DESCRIPTION (provided by applicant): The principal objective is to demonstrate clinically a commercially viable, low-cost, high-resolution fundus camera that: is easy to use, i.e., consistent with the operation of current fundus cameras; has a field of vie w (FOV) that is typical of current fundus cameras (15 to 30 degrees); has a factor of five or more improvement in resolution as compared to exi ...

DESCRIPTION (provided by applicant): Frail older adults represent one of the highest risk populations in disaster events. Characteristics of older adults in long-term care, including impaired physical mobility, reduced cognitive functioning, diminished sen sory awareness, and chronic health conditions, create unique emergency planning challenges. When should a facility evacuate? Where will residen ...