Award Data

Early diagnosis and early treatment of cancer greatly improve the likelihood of long-term survival and health. Chemical structures that are selectively taken by cancerous tissue can be used to pull diagnostic and therapeutic moieties to cancerous tissue. Appropriately sized iron and/or iron oxide nanoparticles are effective for both diagnosis (via magnetic resonance imaging, MRI) and therapy (by h ...

This proposal addresses NASA's need for improved TPS materials. The incumbent CEV heatshield TPS for Orion's Block II lunar return is PICA, a low-density carbon fiber infiltrated with phenolic resin. Variants of PICA with improved thermomechanical properties would benefit future missions. This effort will create a series of "mid-density" ablative materials to fill the gap between low-density PICA ...

Emergent Technologies Corp. (ETC) in conjunction with research partners at West Virginia University has developed and recently patented an innovation antenna that promises to revolutionize the science of antenna design, construction and utilization. The antenna, labeled the Countrawound Toroidal Helical Antenna (CTTHA), offers a number of significant advantages over conventional antennas. The CT ...

DESCRIPTION (provided by applicant): Development of implantable devices for automated detection, quantification, warning and delivery of therapy to block seizures is a very important unmet medical need. Making such a device as small as possible, minimizin g replacement surgeries, and maximizing device longevity and/or time between battery recharging are some of the most important development driv ...

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THIS RESEARCH AND DEVELOPMENT EFFORT IS AIMED TOWARD THE VALIDATION AND USE OF A PORTABLE BIOCHEMICAL DETECTOR ("C-PROBE") AS AN INDICATOR FOR HUMAN EXPOSURES TO CARCINOGENIC CHEMICAL AGENTS IN THE FIELD. DURING PHASE I, C-PROBE RESPONSES TO TEST AGENTS WILL BE COMPARED WITH IN VITRO AND IN VIVO PRODUCTION OF CARCINOGEN-DNA ADDUCTS THAT FORM AS A RESULT OF THE EXPOSURES. SUCCESSFUL COMPLETION OF P ...

THE PURPOSE OF THIS PROJECT IS TO DEVELOP A SELF-INSTRUCTIONAL PROGRAM FOR PARENTS OF CHILDREN WHO ARE DIAGNOSED AS HAVING A LEARNING DISABILITY AND/OR AN ATTENTION DEFICIT DISORDER. THESE TYPES OF DISORDERS CREATE SERIOUS PROBLEMS FOR FAMILIES, YET THERE ARE NO PROGRAMS DESIGNED SPECIFICALLY FOR THIS POPULATION. THIS PROJECT WILL BEGIN BY IDENTIFYING KEY PROBLEM AREAS FOR FAMILIES. SKILLS WILL BE ...

THE AIM OF THIS PROJECT IS TO EVALUATE THE FEASIBILITY OF DEVELOPING ANALYTICAL TECHNOLOGY APPLICABLE TO THE DETERMINATION OF DESMOSINE (DMS) IN THE SYSTEMATIC CIRCULATORY SYSTEM AND IN OTHER PHYSIOLOGICAL SAMPLES. IN VIVO HYDROLYTIC DEGRADATION OF THE CONNECTIVE TISSUE ELASTINBY THE ENZYME ELASTASE PRODUCES DMS-PEPTIDE FRAGMENTS. CURRENT RESEARCH SUGGESTS THAT AN ACCURATE DETERMINATION OF DMS-PEP ...