Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Topic 373: Exonuclease Time-of-Flight for the Low-Cost, Rapid Identification of Methylated RNA Single Molecules

    SBC: Digital Nanogenetics LLC            Topic: NCI

    There is growing interest in the study of RNA modifications and its potential role(s) in many physiological abnormalities, such as modulating many processes associated with cancer development and progression. While RNA sequencing (RNA-seq) using short-read nextgeneration sequencing (NGS) have proven to be a useful tool for identifying specific RNA modifications, there still remains technical chall ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Device for Rapid, Complete & Durable Occlusion of Wide-Neck Cerebral Aneurysms

    SBC: Metactive Medical, Inc.            Topic: 106

    ABSTRACT Metactive Medical is developing the Ballstent Microcatheteran innovative medical device for the endovascular embolic treatment of cerebral aneurysmswhich are a common cause of strokeThe key component of the device is the Ballstentan expandabledetachablegold metal balloon that can be pleated and folded at the distal end of a delivery microcatheteradvanced into an aneurysm sac over a guidew ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Generation of High Resolution Antibody Mimetics to Improve the Visualization of Subcellular Structures by Super Resolution Microscopy

    SBC: Nectagen, Inc.            Topic: 400

    The goal of this Phase I SBIR project is to develop a set of high resolution antibody mimeticsnanoCLAMPsoptimized for super resolution imaging of a broad range of subcellular structuresAdvances in super resolution microscopy have enabled the achievement of resolutions well below the diffraction limit with current techniques now approachingnmFor immunostainingthenm size of antibody complexes now li ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Affinity reagents for the sub-fractionation of specific exosomal populations

    SBC: Nectagen, Inc.            Topic: 400

    The goal of this Phase I SBIR project is to develop affinity reagents useful for the sub fractionation of specific exosomal populationsBecause exosomal makeup and cargo reflect the typedevelopmental stageand the disease state of the cells they are shed fromthey are attractive targets for non invasive diagnosticsExosomes are also being investigated for therapeutic applications such as vaccines and ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Determination of protective efficacy of multimeric Shigella vaccine as the next step toward human trials

    SBC: Hafion LLC            Topic: NIAID

    SUMMARYShigellosisbacillary dysenteryis a severe bloody diarrhea that occurs worldwide and for which there is no licensed vaccineThis disease is particularly devastating in low income regions of the world where clean water and proper sanitation are lackingMortality and morbidity are highest in children under the age ofwith survivors exhibiting impaired growth due to malnutritionShigella sppare als ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Targeting Bioenergetic Flux for Alzheimer's Disease Management

    SBC: Aerobyx LLC            Topic: NIA

    PROJECT SUMMARYBioenergetic dysfunction occurs in Alzheimer s diseaseADand represents a potential AD therapeutic targetFor these reasonswe founded AerobyxLLCThe goal of Aerobyx is to develop drugs that specifically target brain bioenergetic fluxesand to use those drugs to treat persons with ADOur strategy emphasizes fundamental biochemical principles such as the law of mass actionand additionally ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Quantifiable Thermal Therapy Using Magnetic Resonance Thermometry Imaging

    SBC: NeoTherma Oncology Inc.            Topic: 102

    Pancreatic Ductal AdenocarcinomaPDACis the third leading cause of cancer related death in the United Statesand is characterized with dismal odds due to advanced disease at late stage diagnosisTheyear survival rate ranges fromfor patients with non resectable diseaseof patientstofor patients with resectable tumorsandltof patientsPDAClike most solid tumorsis highly hypoxicresulting from both poor oxy ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Development of a Wearable Band-Aid Biosensor System for Alcohol Monitoring

    SBC: Design-Zyme LLC            Topic: 450

    Project Abstract The goal of this Phase I SBIR is to develop a non invasive wearable dermal deviceBand Aidcapable of extracting and sensing ethanol from interstitial space using reverse iontophoresisnot sweat!and transmitting the results wirelessly to a Bluetoothcapable deviceThe proposed band aid patch will be easily applied to the epidermisand will provide monitoring of ethanol levels in a cost ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Isolation and Identification of Prebiotic Nutrient Components

    SBC: Design-Zyme LLC            Topic: NIA

    ABSTRACT Studies of the microbiome of older individuals has shown greatly reduced numbers of known beneficial bacteria coinciding with a greater presence of potentially detrimental bacterial strainsNot surprisinglythe decrease in beneficial microbes coincides with a loss of anti inflammatory activity and genes associated with short chain fatty acid productionThis age related decline in the gut mic ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Ovine Study of Medical Device to Improve Arteriovenous Fistula Maturation

    SBC: Flow Forward Medical, Inc.            Topic: 400

    ABSTRACT This study aims to evaluate the in vivo effectiveness of the Arteriovenous Fistula EligibilityAFESystema small temporary wearable rotary blood pump system that rapidly and persistently dilates peripheral veins prior to arteriovenous fistulaAVFsurgerySuccessful commercialization of the AFE System would enable the creation of AVF vascular access sites in hemodialysis patients who are curren ...

    SBIR Phase I 2018 Department of Health and Human Services
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