Award Data

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DESCRIPTION (provided by applicant): Phase I. In the treatment of cancer, radiation therapy has been limited by the tolerance of the surrounding normal tissues, such as lung or mucosa. Until now, there have been no compounds available that protect the normal tissues without reducing the tumor response to radiation therapy. The overall goal of this project is to develop a new approach to radiation ...

DESCRIPTION (provided by applicant): The National Institutes of Allergy and Infectious Disease have called for better tools for the detection and diagnosis of emerging and re-emerging infectious diseases. The need is for tests that are practical and affordable for use in resource poor settings, such as local public health departments in underdeveloped countries, disaster situations anywhere, an ...

DESCRIPTION (provided by applicant): The CDC states that lead poisoning is the number one environmental health problem affecting children in the US because it affects one of every six at-risk children and it is acknowledged to be a source of cognitive and behavioral impairment. Only 25% of the at-risk US children are tested. Atomic absorption instruments do 80% of blood lead tests in the US, but t ...

DESCRIPTION (provided by applicant): A hallmark of cancer is deregulated activation of the signal transduction pathways controlling proliferation, apoptosis, and differentiation. The signal transduction pathways culminate in activation of transcription factors (TFs), proteins that bind promoter regions of genes, thereby controlling transcription initiation. To understand the complex regulation ...

DESCRIPTION (provided by applicant): Toxicogenomics has emerged as a radical alternative to the slow, expensive and inefficient conventional toxicological approaches. The toxicogenomic approach is based on the premise that exposure to toxic agents elicits unique patterns of gene expression that can be assessed by using gene array technology. However, analyzing expression patterns of tens of thou ...

DESCRIPTION (provided by applicant): Current microarray techniques are subject to inherent variability directly related to the inability of array deposition systems to accurately identify and record the location of arrayed materials and to communicate this information to follow-on systems for use in post-deposition array processing, readout and analysis. The inability to easily identify, record an ...

DESCRIPTION (provided by applicant): Hypersecretion of mucus into the respiratory airways is a major factor in several lung diseases, including chronic bronchitis, asthma, cystic fibrosis, and bronchiectasis. Despite the obvious medical importance, mechanisms that regulate production and secretion of airway mucus have not been elucidated fully, and, relatedly, there presently are no effective ther ...

DESCRIPTION (provided by applicant): Pretest probability assessment plays an important role in the evaluation of pulmonary embolism (PE) in the emergency department (ED). Current methods of pretest probability assessment produce categories of risk that tend to over fit individual patients. The hypothesis of this work is that the pretest probability of PE can be accurately estimated by computerize ...

DESCRIPTION (provided by applicant): The Genomics Revolution and the resultant explosion of knowledge in genomics are shaping our futures. Therefore, it is crucial that knowledge of genomics is broadly disseminated, so that future scientists, educators, policy makers, community leaders, and heads of households can harness the beneficial power of genomic science. Given the indiscriminate impact of ...