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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: Oculo Therapy, LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the worldElevated intraocular pressureIOPis the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucomathe most common form of glaucomaThe current standard of care for glaucoma includes IOPlowering medications delivered topically as eye dropswhich decrease the vol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Targeted Intraceptors for Macular Degeneration

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: NEI

    Project Summary Age related Macular DegenerationAMDis the leading cause of blindness in USIt affects overof the people by the ageAn estimatedmillion people are afflicted with AMD worldwideNeovascular orwetAMDwhich affectsof AMD patientsis a rapid form of the disease and progresses to blindness if left untreatedHistopathologicallythe disease involves lesions in the Bruchandapos s membrane and or re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Accessible And Robust Tools for Glycosaminoglycan Profiling

    SBC: ECHELON BIOSCIENCES, INC.            Topic: 300

    GlycosaminoglycansGAGsare polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrixMore recentlychanges in the contentsizeand composition of GAGs have been found to play biological roles in disease processes as wellFor examplechondroitin sulfateCSis the most abundant GAGhoweveronly th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Natural Products-Based High Throughput Screen: Identification of Correctors of Cystic Fibrosis Misfolding Mutants

    SBC: Synthetic Biodesign, LLC            Topic: NCCIH

    Natural products or their derivatives have accounted for most of our current drugsdemonstrating their unique status asprivilegedmolecules that are well adapted for therapeutic useHowevernatural products have previously been unsuitable for modernhigh throughputHTdrug discovery screening approachesand as suchwere long ago abandoned in drug discovery programs of large pharmaThe substitute has been hi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Identifying the precursor to oxytocin-induced uterine tachysystole by monitoring with uterine EMG

    SBC: PreTel, Inc.            Topic: NICHD

    Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos s diversitAbplatform by continuing advanced development of Transchromosomic goatsTcGsThis will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos s human artificial chromosomeHACwhich encodes the entire ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Dual-Tracer Cardiac PET Imaging

    SBC: MULTIFUNCTIONAL IMAGING, LLC            Topic: NHLBI

    Abstract Radiologic imaging plays an important role in the care of patients with a variety of heart diseasesand the ways in which imaging are used for cardiac patients is rapidly evolvingIn the pasthigh end cardiac imaging has been dominated by rest stress procedures for evaluating myocardial perfusion in patients with known or suspected coronary artery diseaseIn the modern agehowevercardiac imagi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Expanding the Tool Box: Environmental Metabolomics Improves Decision Making and Management of Contaminated (Superfund) Sites

    SBC: Microbial Insights, Inc.            Topic: NIEHS

    Project Summary Abstract Metabolomics is a relatively novel Molecular Biological ToolMBTwhich employs highly sensitive instrumentation to obtain a measure of all small organic molecules present in a biological sampleContemporary MBTs rely on quantitative PCR and measure the presence and abundance of keystone bacteriae gDehalococcoidesinvolved in the detoxification of priority contaminants such as ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Stabilization of the Alveolar-Capillary Barrier with ARF6 Inhibitor as a Treatment for Severe Influenza

    SBC: NAVIGEN, INC.            Topic: NHLBI

    SUMMARYInfluenzavirusinfectionisoneofthemostcommonacuterespiratorydiseasesandremainsoneofthelargestdiseaseburdensonhumanswithsevereprimaryviralpneumoniaoftenresultingindeathThepathogenicityofinfluenzaincludesahostresponsethatcanincludeaseveresystemicinflammatoryreactioncytokinestormandensuingvascularleakVascularleakisafundamentalelementinthepathogenesisofcirculatoryshockandmultipleorganfailurewhic ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Novel peptide reagents for imaging damage to collagen structure in histopathology and in vivo

    SBC: 3Helix, Inc.            Topic: 200

    Project SummaryHelixIncIn this Phase II SBIR proposalHelix Incproposes to develop a new user friendly imaging agent that can detect denatured collagen in histological tissue section and in vivo animal imagingCollagen is the major structural component of nearly all human tissues and organsproviding a sturdy and bioactive framework for cell growth and tissue formationAlthough degradation of collagen ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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