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With growing regulatory concern over the release of waterborne industrial pollutants, the US Environmental Protection Agency has identified metal finishing as an industrial operation whose pollutant discharge poses a significant threat to public health and the environment. Currently, the US Department of Defense (DoD) weapon system operations rely on metal hydroxide precipitation to treat metal fi ...

In this effort, powered upper extremity (two arms and modular, unpowered, application-specific end effectors) of a wearable exoskeleton robot used to augment human performance while performing logistical tasks will be developed, tested and demonstrated. The new exoskeleton, referred to as XO-MAX(UE)-L exoskeleton, will be integrated with the Lower Extremity, XO-MAX(LE)-L exoskeleton, developed und ...

Glaucoma is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) is the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucoma, the most common form of glaucoma. The current standard of care for glaucoma includes IOP- lowering medications delivered topically as eye drops, which de ...

Project Summary Age-related Macular Degeneration (AMD) is the leading cause of blindness in US. It affects over 25% of the people by the age 80. An estimated 25 million people are afflicted with AMD worldwide. Neovascular or “wet” AMD, which affects 10%–15% of AMD patients, is a rapid form of the disease and progresses to blindness if left untreated. Histopathologically, the disease involves ...

Glycosaminoglycans (GAGs) are polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrix. More recently, changes in the content, size, and composition of GAGs have been found to play biological roles in disease processes as well. For example, chondroitin sulfate (CS) is the most abunda ...

Natural products or their derivatives have accounted for most of our current drugsdemonstrating their unique status asprivilegedmolecules that are well adapted for therapeutic useHowevernatural products have previously been unsuitable for modernhigh throughputHTdrug discovery screening approachesand as suchwere long ago abandoned in drug discovery programs of large pharmaThe substitute has been hi ...

Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

Project Summary/Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos;s diversitAb™ platform by continuing advanced development of Transchromosomic goats (TcGs). This will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos;s human artificial chromosome (HAC) which encod ...

Abstract Radiologic imaging plays an important role in the care of patients with a variety of heart diseasesand the ways in which imaging are used for cardiac patients is rapidly evolvingIn the pasthigh end cardiac imaging has been dominated by rest stress procedures for evaluating myocardial perfusion in patients with known or suspected coronary artery diseaseIn the modern agehowevercardiac imagi ...