Award Data

THE LONG-RANGE GOAL OF THIS PROGRAM IS THE DEVELOPMENT AND COMMERCIALIZATION OF PROTON ACCELERATORS SUITABLE FOR RADIATION THERAPY OF CANCER IN HOSPITAL OR CLINICAL SETTINGS. FOR THIS PURPOSE THE ACCELERATOR SHOULD HAVE AN ENERGY UP TO 250 MEV, AND MUST BE SIMPLE, RELIABLE, AND INEXPENSIVE COMPARED TO EXISTING ACCELERATORS FOR PHYSICS APPLICATIONS. IN ADDITION, WITH SUFFICIENT INNOVATION, IT COULD ...

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THE LONG TERM OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT AND MARKETING OF EASILY SWALLOWED ELECTRODES FOR TEMPORARY TRANSESOPHAGEAL CARDIAC PACING. THIS "PILL ELECTRODE" CAN REPLACE CARDIAC CATHETERIZATION IN A VARIETY OF DIAGNOSTIC AND THERAPEUTIC APPLICATIONS, INCLUDING INITIATION AND/OR TERMINATION OF TACHYCARDIAS, SHORT TERM MAINTENANCE OF ADEQUATE RATE IN SINUS BRADYCARDIA, ACCELERATION OF ...

THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP QUANTITATIVE ESTROGEN RECEPTOR CONCENTRATION MEASUREMENTS USING HIGH- RESOLUTION DIGITAL IMAGE MICROSCOPY TECHNIQUES. THE TECHNIQUES WILL ENABLE DIRECT MEASUREMENTS OF RECEPTOR CONCENTRATION ON A CELL-BY-CELL BASIS. THIS IS AN IMPROVEMENT OVER THE CURRENT BIOCHEMICAL ASSAYS, WHICH GIVE ONLY AN AVERAGE VALUE FOR RECEPTOR CONCENTRATION. THE QUANTITATIVE AS ...

THE PRIME LONG-TERM OBJECTIVE OF THIS PROJECT IS TO UPDATE, ENHANCE, AND DISTRIBUTE TWO COMPUTER PROGRAMS UTILIZING THE UNIQUE MULTIVARIATE ANALYSIS TECHNIQUES DEVELOPED BY THE PSYCHOLOGIST ROBERT TRYON WITH NIH SUPPORT DURING THE 1960S. ONE LONG-TERM GOAL IS TO PRODUCE AN ENHANCED ALL-FORTRAN VERSION OF A MAIN BCTRY82 SYSTEM, PORTABLE TO MOST LARGE COMPUTERS. A SECOND LONG-TERM GOAL IS TO PRODUCE ...

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TECHNOLOGY DEVELOPED ABROAD HAS INDICATED THE FEASIBILITY OF PREPARING DENTAL CASTINGS OF TITANIUM AND TITANIUM ALLOYS BY BOTH ELECTRIC ARC AND VERTICAL CENTRIFUGAL CASTING IN AN ARGON ENVIRONMENT. WE PROPOSE TO EVALUATE THE FEASIBILITY OF THESE CASTING TECHNIQUES TO FABRICATE PARTIAL DENTURE FRAMEWORKS AND SUBPERIOSTEAL IMPLANT FRAMEWORKS FROM IMPLANT GRADE TI-6A1-4V IN THE ENVIRONMENT OF AN AMER ...

OPEN LITERATURE THE OBJECTIVE OF THIS PROGRAM IS TO ESTABLISH AN INFRASTRUCTURE UNDER WHICH AGENTS THAT DEMONSTRATE POTENTIAL CHEMOPREVENTIVE ACTIVITY CAN BE IDENTIFIED. RECENT DISCOVERIES WITH SMALL CLASSES OF AGENTS HAVE SHOWN CHEMOPREVENTIVE ACTIVITY IN ANIMAL MODELS FOR HUMAN CANCERS, AND CLINICAL TRIALS FOR SEVERAL OF THESE ARE NOW BEING PLANNED. AN IMMEDIATE GOAL OF THIS PROJECT IS TO PRIORI ...

COMPUTERS HAVE BECOME MAJOR TOOLS IN SCIENCE AND BUSINESS. THERE HAS BEEN EVOLUTION IN THE WAY IN WHICH COMPUTERS ARE USED; FROM INTEGRAL TABLE CALCULATION TO EXPERT SYSTEMS AND FROM PAYROLL PRODUCTION TO SIMULATION OF BUSINESS ACTIVITIES. ONE CHALLENGE REMAINING IS THE GENERATION OF SYSTEMS TO ASSIST IN MANAGEMENT. A PRIMARY INDICATOR OF BUSINESS SUCCESS IS THE CAPABILITY TO ASSESS THE INFORMATIO ...

THE OBJECTIVE OF THIS PROGRAM IS TO ESTABLISH A METHOD BY WHICH CANCER TREATMENTS NOT BEING INVESTIGATED THROUGH CONVENTIONAL CHANNELS CAN BE IDENTIFIED, ORGANIZED INTO A DATABASE, AND DISSEMINATED TO INTERESTED PARTIES. ORGANIZING THIS INFORMATION WILL PROVIDE A MEANS FOR IDENTIFYING UNSCRUPULOUS METHODS AND ALLOW THOSE TREATMENTS WITH PROMISE TO BE BROUGHT TO CLINICAL TRIALS. AN IMMEDIATE GOAL O ...