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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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A single dose long-acting non-addictive polymer conjugate formulation of buprenorphine that provides immediate and prolonged analgesia for post-operative pain
SBC: SERINA THERAPEUTICS INC Topic: NINDSPAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
SAGE LEAF:Reducing Burden in Alzheimer's Disease Caregivers through Positive Emotion Regulation and Virtual Support
SBC: BRIGHTOUTCOME INC. Topic: NIAPROJECT SUMMARY The prevalence of Alzheimer’s Disease (AD) and other dementias is steadily climbing and predicted to affect as many as 16 million Americans by 2050. In 2016, 59% of dementia caregivers reported experiencing high levels of emotional and physical stress, and the risk that the chronic stress of dementia caregiving places on caregivers for developing a range of physical and mental he ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Fiber-DeliveredProgrammableSupercontinuumLaserAdaptivetoEvolvingNeurophotonicResearch
SBC: LiveBx, LLC Topic: 101SUMMARY Neurophotonics, including the prominent example of optogenetics, has been the driving force for brain research and one focal area of the NIH BRAIN Initiative established in 2013. In contrast to the genetic and biophotonic advancements that have transformed this field, the progress in laser source technology underlying these advancements has lagged behind, resulting in three technical barri ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Development of group 2 influenza A virus entry inhibitors
SBC: Chicago Biosolutions, Inc. Topic: NIAIDInfluenza A viruses belong to the Orthomyxoviridae family with a negative-sense, segmented RNA genome, which can cause seasonal or pandemic flu with high morbidity and significant mortality. Vaccination is the most prevalent prophylactic means for controlling influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Furthermore, vac ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysms
SBC: ENDOMIMETICS LLC Topic: NINDSApproximatelyof the population has unruptured cerebral aneurysmsapproximatelymillion people in the USAboutrupture per yearwith devastating consequencesAboutof patients with ruptured aneurysms dieandofwho survive have significant disabilitiesCoil embolization therapy is associated with a high rate of recurrenceFlow diverters are increasingly being used to cover the neck of the aneurysm providing mo ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Maximizing the safety profile of a novel cancer therapeutic via the de-immunization of an engineered mammalian asparaginase
SBC: Enzyme by Design Inc. Topic: 102Project Summary: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 20-012. The goal of this supplement is to build upon the amazing progress made in the parent Phase 1 SBIR in developing a less immunogenic asparaginase (ASNase) by adding pivotal studies that would demonstrate its reduced immunogenicity, potent anti-ALL action, and superi ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Developing Insulin-like growth factor binding protein 2(IGFBP2)peptide fragment-based therapeutics to treat functional and behavioral deficits in Phelan-McDermid Syndrome.
SBC: ALISBIO LLC Topic: 101ABSTRACTAlisBio is developing novel therapeutics based on Insulin like growth factor binding proteinIGFBPpeptide fragments to treat functional and behavioral deficits in Phelan McDermid SyndromePMSa monogenic form of autism spectrum disorderASDaccounting forof ASD diagnosesThe focus of this Phase I grant is to demonstrate that proprietary IGFBPmimetic peptide fragments reverse disease relevant cel ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Array Based Affinity Selection
SBC: Tango Biosciences Inc. Topic: 300Project Summary Funds are requested to apply technologies being developed in a current NIGMS award to generate recombinant antibody-like affinity reagents to the spike protein of the SARS-CoV-2 virus. As a proof-of-principle experiment, we have already isolated four fibronectin type III (FN3) monobodies that bind with low nanomolar affinity to the receptor binding domain (RBD) of the viral spike p ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Computerized Adaptive Suicidal Risk Stratification and Prediction
SBC: ADAPTIVE TESTING TECHNOLOGIES INC Topic: 104ABSTRACT In the next 60 minutes, at least 57 people in the United States (US) will attempt to kill themselves, and five will die. Over 80% of these individuals encountered a healthcare provider in the 12 months before his or her death, but their risk will have gone undetected or, if detected, poorly quantified and not sufficiently monitored longitudinally. The proposed research will address this d ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
STING Inhibitor Discovery for Rare and Common Autoimmune Diseases
SBC: DISCOVERYBIOMED, INC. Topic: NIAIDPrincipal Investigators for Small BusinessDiscoveryBioMedIncDBMand Nitor TherapeuticsIncNitorProject Summary Abstract The over arching commercial goal for this Nitor TherapeuticsIncNitorand DiscoveryBioMedIncDBMcollaboration is to discover and validate Stimulator of Interferon Genes orSTINGinhibitor ligands in a novel high throughput screeningHTSand validation based Critical Path of bioassaysAberr ...
SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health