Award Data

THE LONG-RANGE GOAL OF THIS PROGRAM IS THE DEVELOPMENT AND COMMERCIALIZATION OF PROTON ACCELERATORS SUITABLE FOR RADIATION THERAPY OF CANCER IN HOSPITAL OR CLINICAL SETTINGS. FOR THIS PURPOSE THE ACCELERATOR SHOULD HAVE AN ENERGY UP TO 250 MEV, AND MUST BE SIMPLE, RELIABLE, AND INEXPENSIVE COMPARED TO EXISTING ACCELERATORS FOR PHYSICS APPLICATIONS. IN ADDITION, WITH SUFFICIENT INNOVATION, IT COULD ...

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THIS PROJECT WILL STUDY THE REMOVAL OF SOX FROM COM- BUSTION PROCESS FLUE GASES FOLLOWED BY DIRECT CONVERSION TO ELEMENTAL SULFUR, USING CHELATED IRON THAT HAS BEEN REDUCED TO FORM A CHELATE:FES COMPLEX. THE PROCESS WOULD HAVE SALEABLE ELEMENTAL SULFUR AS THE ONLY SIGNIFICANT BYPRODUCT AND WOULD OPERATE WITH THE CHELATED IRON AS A REGENERABLE CATALYTIC REAGENT. THE REACTIONS TO BE EXAMINED IN THIS ...

THE LONG TERM OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT AND MARKETING OF EASILY SWALLOWED ELECTRODES FOR TEMPORARY TRANSESOPHAGEAL CARDIAC PACING. THIS "PILL ELECTRODE" CAN REPLACE CARDIAC CATHETERIZATION IN A VARIETY OF DIAGNOSTIC AND THERAPEUTIC APPLICATIONS, INCLUDING INITIATION AND/OR TERMINATION OF TACHYCARDIAS, SHORT TERM MAINTENANCE OF ADEQUATE RATE IN SINUS BRADYCARDIA, ACCELERATION OF ...

CONSIDERABLE EVIDENCE EXISTS THAT ANALYSIS OF THE ELECTRO- CARDIOGRAM OVER EXTENDED PERIODS OF TIME PROVIDES CLINICALLYSIGNIFICANT INFORMATION IMPORTANT IN THE DIAGNOSIS AND TREATMENT OF CARDIAN DISEASE. AVAILABLE AMBULATORY MONITOR-ING DEVICES ARE ADEQUATE FOR 24-HOUR PERIODS; LIMITATIONS ARE EVIDENT WHEN LONGER PERIODS ARE REQUIRED. THE PROJECT WILL ESTABLISH THE FEASIBILITY OF BIOLOGICAL DATA A ...

ALTHOUGH PROSTHETIC HEATT VALVES HAVE BEEN IN CLINICAL USE SINCE 1960, A NEED EXISTS FOR A VALVE THAT DOES NOT REQUIRE ANTICOAGULANTS AND HAS A LONG LIFE EXPECTANCY. BIOCONTROL TECHNOLOGY, INC. HAS DEVELOPED A VALVE THAT PROMISES TO MEET THESE CRITERIA. IT RESEMBLES THE HUMAN AORTIC VALVE, OR THE PORCINE OR BOVINE VALVES, BUT IT IS MADE OF BIOCOMPATIBLE, FATIGUE-RESISTANT CORAFLEX POLYURETHANE. TH ...

THIS PROJECT WILL DEVELOP AN INEXPENSIVE, PORTABLE EMG BIOFEEDBACK INSTRUMENT TO AID IN THE TREATMENT OF URINARY INCONTINENCE IN WOMEN AND MEN. THIS INSTRUMENT WILL MONITOR, EVALUATE, AND COUNT VOLUNTARY EXERCISE CONTRACTIONSOF THE PUBOCOCCYGEUS MUSCLE IN ORDER TO ASSURE PATIENT COMPLIANCE WITH NURSING INSTRUCTIONS, AND TO ASSURE MORE EFFICIENT PATTERNS OF THERAPEUTIC INTERVENTION IN THE RESTORATI ...

THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP QUANTITATIVE ESTROGEN RECEPTOR CONCENTRATION MEASUREMENTS USING HIGH- RESOLUTION DIGITAL IMAGE MICROSCOPY TECHNIQUES. THE TECHNIQUES WILL ENABLE DIRECT MEASUREMENTS OF RECEPTOR CONCENTRATION ON A CELL-BY-CELL BASIS. THIS IS AN IMPROVEMENT OVER THE CURRENT BIOCHEMICAL ASSAYS, WHICH GIVE ONLY AN AVERAGE VALUE FOR RECEPTOR CONCENTRATION. THE QUANTITATIVE AS ...

PHASE I WILL INVESTIGATE THE FEASIBILITY OF CONDUCTING LARGER STUDIES TO DETERMINE WHETHER THE CA 125 IMMUNORADIOMETRIC ASSAY (IRMA), WHICH MEASURES TUMOR-ASSOCIATED ANTIGENIC DETERMINANTS IN SERUM, WILL BE USEFUL FOR EARLY DETECTION OF OVARIAN CANCER AMONG ASYMPTOMATIC WOMEN. THE AIMS OF THE PRESENT INVESTIGATION WILL BE 1.TO FORMULATE A FINAL PROTOCOL FOR A LARGER STUDY; 2.TO DEVELOP METHODS TO ...