Award Data

It is estimated that 220,000 people suffer cardiac arrest each year in the US, of whom only 10,000 survive to hospital discharge. The number of survivors could increase 10-fold if paramedical attention and/or defibrillation were available within a few min

DESCRIPTION (provided by applicant): The goal of this small business technology transfer application is to validate and commercialize an improved means of polyp detection during colonoscopy: spectroscopic microvascular blood assessment from the endoscopically normal mucosa. Missed lesions on colonoscopy are a major problem (conservatively estimated to be ~25% of adenomas and ~4-5% of carcinomas) w ...

DESCRIPTION (provided by applicant): The long-term objective of this research is to develop a non-invasive approach for early assessment of de novo 3MH production in cancer patients as a way of assessing which patients are at high risk for future developme nt of skeletal muscle atrophy. The approach is based on the known increase in the rate constant for de novo production of 3-methylhistidine (3M ...

DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to develop an inexpensive, totally non-invasive surrogate test for the 2-h oral glucose tolerance test (2-h OGTT) for the purpose of identifying individuals with pre-diabete s for preventive purposes. We believe that such a test can be developed based on oral administration of a 75-g 13C-labeled glucose solution adm ...

DESCRIPTION (provided by applicant): Breast cancer is the leading cause of cancer deaths in the United States. In this year alone, approximately 40,480 women in the US are estimated to die from breast cancer. In most cases, death results from metastasis of breast cancer cells. Cancer patients with metastasis cannot currently be cured. Therefore, the invention of therapy to treat breast cancer met ...

DESCRIPTION (provided by applicant): Chronic infections with hepatitis B or hepatitis C viruses are global health problems affecting hundreds of millions of people worldwide. Various commercial products of interferon alpha are approved in the United States for the treatment of adults with hepatitis B and hepatitis C. However, therapy with interferon involves multiple weekly injections via intramu ...

DESCRIPTION (provided by applicant): The goal of this specific project is to develop a cost-effective proactive telenursing system for the management of chemotherapy side effects. Patients will use this system to report health status on a daily basis durin g treatment, either on the Web or via interactive voice response system over the phone. Depending on the reported severity, the system may deli ...

The aim of this study is to facilitate the early detection of colorectal cancer (CRC) by developing a care coordination system that will facilitate both screening and diagnostic processes via e-health, telemedicine, clinical decision support, patient-reported risk information, patient education and coordinated care models and technologies. Specifically, the project aims to 1) provide alerts to hea ...

Our long-term objective is to develop a computer system facilitating the use of patient-reported outcomes (PRO) information to monitor patient status and assist clinical decision making for cancer patients under palliative and hospice care. This system will integrate PRO and other clinical data with evidence-based treatment guidelines and pathways to care and interface with and foster collaborativ ...

DESCRIPTION (provided by applicant): Optical imaging as a noninvasive diagnosis technique is a highly promising tool for real-time, in-vivo detection of tumor margins during breast-conserving surgery. This can decrease false-negative diagnoses and local re currences of the cancer that occur after conventional diagnoses and lumpectomy. Its clinical application has been held back by lack of suitable ...