Award Data

Microphysiological systemsMPSdevelopment has advanced as a means to reducerefineand replace animal studiesto improve models of human diseaseUsage of MPS systems for such applications will require standardization of technology componentsTowards this effortNational Center for Advancing Translational SciencesNCATSinvestigators have identified the need for a universal medium for supporting the surviva ...

The goal and significance of this project is to develop a clinically usable diagnostic test for gastrointestinal disease and to reduce healthcare costsNecrotizing enterocolitisNECis the most frequent and lethal gastrointestinal disease for preterm infantsIt affects newborns at a rate ofperUS births per year and has an average total in hospital treatment cost of $per patientAlthough first described ...

PROJECT SUMMARY Alzheimer’s disease (AD) is the sixth leading cause of death in United States, yet this indication lacks truly effective therapeutics to mitigate this disease. To address this problem, a novel (partial) peroxisomal proliferator activating–gamma (PPAR) nuclear receptor agonist (AU-9) that has selective amino acid interactions in the receptor ligand-binding domain was develope ...

PROJECT SUMMARYPeripheral artery diseasePADis a serious cardiovascular disease affectingmillion people worldwidePAD is defined by a blockage of arteries in the lower extremitiesand is associated with painpoor wound healingand without interventionlimb loss and deathDrug coated balloonsDCBare an emerging clinical intervention aimed at clearing blocked arteriesparticularly those that are difficult to ...

PROJECT SUMMARY Pulmonary fibrosis is a leading cause of death worldwide. With a median survival of only 2.5 years after diagnosis, it is responsible for millions of deaths worldwide and billions in health care costs each year. Besides mortality, pulmonary fibrosis, of which the idiopathic type is most common, brings about tragic morbidity. Without a known cause of idiopathic pulmonary fibrosis, v ...

THIS PROJECT IS THE FIRST PHASE OF A LONG-TERM, JOINT VENTURE BETWEEN HELIX INTERNATIONAL CORPORATION AND THE UNIVERSITY OF SOUTHWESTERN LOUISIANA TO ESTABLISH A COLONY OF MONOZYGOTIC NONHUMAN PRIMATE TWINS FOR BIOMEDICAL RESEARCH MODELS AND TO DEVELOP THE TECHNOLOGY AND IN-HOUSE EXPERTISE FOR INITIATING WORK IN INTERSPECIES EMBRYO TRANSFER IN ENDANGERED PRIMATES. DURING THE COURSE OF THIS RESEARC ...

THE OBJECTIVE OF THE RESEARCH PROPOSED IN THIS APPLICATION IS TO DEVELOP AND TEST AN INSTRUMENT FOR IN VIVO MEASUREMENT OF ERYTHROCYTE VELOCITY AND MICROSPECTROPHOTOMETRY FOR OXYHEMOGLOBIN SATURATION DETERMINATION. THE FIELD OF MICROCIRCULATORY RESEARCH CONTINUES TO BE DEPENDENT UPON THE DEVELOPMENT OF SPECIALIZED INSTRUMENTATION FOR MEASUREMENT OF MICROVASCULAR HEMODYNAMIC VARIABLES. THE COMMERCI ...

PIG MUCOSAL GLYCOSAMINOGLYCANS (GAGS) WILL BE SYSTEMATICALLY FRACTIONATED TO SEPARATE THE COMPONENT HEPARINS, HEPARAN SULFATES, AND DERMATAN SULFATE ACCORDING TO THEIR ANIONIC FUNCTIONALITY BY CHARGE DENSITY. THESE COMPONENT GAGS WILL ALSO BE SEPARATED USING MEMBRANE ULTRAFILTRATION INTO VARIOUS MOLECULAR WEIGHT SIZES. THE GAGS WILL BE EXTRACTED FROM THE CRUDE MUCOSAL MIXTURE OR AS ISOLATED FRACTI ...