Award Data

Project Summary Opioids like morphine and hydrocodone are generally the most effective therapeutics for treatment of moderate to severe pain. However, their use is limited by serious side effects - tolerance, constipation, respiratory depression, physical dependence and high addictive potential. The frequency of clinical pain, coupled with a lack of alternative therapeutic options has led to a nat ...

Dopamine receptors are a family of G protein-coupled receptors (GPCRs), and can be further divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subfamilies. In this proposal, we focus on D1 receptor, which is widely expressed in brain at high levels. Modulation of D1 activity is implicated in the treatment of many psychiatric and neurological disorders, such as schizophrenia, attention def ...

PROJECT SUMMARY GoDx, Inc. has been developing a prototype multiplexed paper strip device for the detection of the DNA and RNA of gastrointestinal pathogens at the point-of-need in andlt; 30 minutes with funding from the NCATS SBIR parent grant TR 001912. We have used the same platform technology we are developing in the parent grant to develop a rapid (andlt;30 minute), low-cost and instrument-fr ...

Mezzo and its partners will design, manufacture, and test a supercritical CO2 recuperator designed for high pressure of 275 bar and high temperature of 800 0C. The recuperator will incorporate a new manufacturing approach (laser welded micro tubes) that offers potential to reduce cost. It is well known that recuperator costs are currently very high for applications that involve high temperature an ...

In this proposal, CompRex, LLC (“CompRex”) seeks to realize a transformational and disruptive advancement in heat exchange technology for high temperature and high pressure applications through 1) the use of advanced metal and ceramic composite material, 2) development of a new simplified manufacturing approach, and 3) optimization of heat exchanger design to maximize the performance benefits ...

The goal of this project is to develop a novel experimental protocol utilizing the fundamentals of cutting-edge materials science, chemistry, and advanced nanoengineering to create a first-of-its-kind multifunctional cementitious coating material that mitigates the detrimental effects of irradiation, heat, and corrosive in nuclear power plants. Capitalizing on our promising preliminary results, th ...

The project team will develop the EdMod platform for special education practitioners to enter and track information specific to IEPs, such as diagnosis classification, goals, and data collection of those goals. The platform will then generate research-based strategies for teachers to support students with or at risk for disabilities during classroom instruction or in testing. The platform will pre ...

In this project, the team will develop a performance-based lab for the high school level. The Inq-ITS Performance Based Labs for High School Physics and Physical Science will integrate "using mathematics" practices with other science practices to study physics/physical science phenomena. An accompanying teacher dashboard will generate immediate, diagnostic, and actionable alerts driven by algorith ...

In this project, the team will create the technology-delivered version of Reading Roots II: Reading "Between the Lions," by integrating content from Between the Lions, including multimedia videos and learning games to personalize learning. To participate in the intervention, students will work for 10 to 30 minutes per day in pairs while sharing a laptop or tablet. Students will alternate in roles ...

History Maker VR is a playful virtual reality (VR) content-creation tool that allows students to embody historical characters in immersive settings, record performances featuring those characters, and share their performance files to demonstrate material mastery. History Maker VR is designed to scaffold creative storytelling, and to encourage embodied learning and for students to take pride in con ...