Award Data

With this phase I submissionIsoPlexis proposes to deliver comprehensive profiling of the immune system as a measure of age dependent health in response to medical challenges or traumaThis assay will connect signaling events in the metabolome and proteome from thousands of single cells in parallel enabling the simultaneous tracking of metabolic activity and protein signaling within each immune cell ...

While CAR-T therapies have advanced in the clinic, there are still two specific issues using these breakthrough therapies for blood cancers: Durable responses in patients are only at 30-50% and Cytokine Release Syndrome occurs in 60-90% of treated patients. These limitations, for a drug that costs as much as $500,000, may cost an additional $250,000+ for treating adverse events leading to caution ...

ABSTRACT Stroke is the fifth leading cause of death and the leading cause of disability in the United StatesThere remains a critical need for innovative therapeutic approaches that can successfully prevent or reverse brain injury following strokeDysfunction of the mitochondrial biochemistry following ischemic stroke and reperfusion injury contributes to significant neuronal cell losshoweverthe dev ...

The Contractorwill use modern technology to develop a fully integratedcommercially viable device for controlled pharmaceutical drug detectiondeactivationand disposal to ensure compliance with DEA regulations and deter opioid theft

OBJECTIVES OF THIS PROJECT ARE TO DEVELOP AN INEXPENSIVE DISPOSABLE UNDERGARMENT DEVICE FOR EARLY AUTOMATIC DETECTION OF URINATION AND TO DESIGN A QUANTITATIVE DEVICE TO BE USED IN CLINICAL RESEARCH AND OTHER APPLICATIONS. THE ELECTRONIC OUTPUT OF THE DETECTOR SYSTEM WILL TRIGGER A SIGNAL TO BE OBSERVED BY THE PERSON WEARING THE GARMENT AND/OR BY OTHERS (NURSE, ETC.). THE DEVICES WILL BE USEFULL A ...

TuberculosisTBkilled an estimatedmillion people in the world inOverof the mortalities associated with this deisease occurred in regions of the world where access to reliable TB testing and other suppotive infrastructure is severely limitedUntil there are pivotal technological innovations in the diagnosis of TB for point of carePOCapplicationthe ambitious goals of the WHO s End TB strategyareductio ...

IsoPlexis proposes to deliver a novel multi-omic method for targeted profiling of both the TCR sequence and proteome from an array of 1000+ single cells. Specifically, we will deliver a single-cell, TCR sequencing and protein capture assay for identifying responsive antigen specific TCRs, and concurrently evaluate these T-cells for functional response to that antigen. The challenge remains to link ...

Although signal transduction inhibitors occasionally offer clinical benefit for cancer patients, signal flux emanating from oncogenes is often distributed through multiple pathways, potentially underlying the resistance which causes failure of most such inhibitors. Measuring signal flux through multiple pathways, in response to signal transduction inhibitors, may help uncover network inter- action ...

This project develops and tests a Bluetooth compliant tongue-based electronic controller (a.k.a. “Mouth Mouse”), designed to give people with upper limb disability control of peripheral devices including computers and communication systems, home automation, and powered wheelchairs, as well as many other Bluetooth compliant devices and new technologies to come in the future. The Mouth Mouse is ...

Project Summary Specific AimThere are numerous needs in the pharmaceutical industry to use and recover high purity solventsKey uses includehigh purity alcohol for various applicationsthe ability to develop low cost dewatering of solvents and a relatively gentle and simple process for dewatering solvent under mild conditionsCompact Membrane SystemsCMSproposes a novel membrane process that can lead ...