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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of Membrane Anchored Cytokines as Novel Vaccine Adjuvants for the Elderly

    SBC: METACLIPSE THERAPEUTICS CORP            Topic: NIAID

    lnterleukinILand granulocyte macrophage colony stimulating factorGM CSFare endogenous immune activatorsEarlier studies using soluble ILand GM CSF as vaccine adjuvants were unsuccessful due to toxicity or suboptimal responseWe developed versions of ILand GM CSF with a glycosylated phosphatidylinositolGPIanchor added at the carboxyl terminusallowing incorporation into lipid bilayers such as in influ ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Creating Antibodies to Enable the Study of Mycobacterium Tuberculosis Infections in Guinea Pigs

    SBC: GLYCOSCIENTIFIC, L.L.C.            Topic: NIAID

    Tuberculosis is a persistent infectious disease that threatens the health of people and numerous mammalian species throughout the worldMonitoring of Mycobacterium tuberculosisMtbinfections in animal models has often relied on host mortalitybacterial loadsand qualitative assessment of pathology at necropsyThese are blunt toolslargely unrelated to the markers used for diagnosis and epidemiological s ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Novel sanitizer/disinfectants against viral infections with long-lasting effect

    SBC: CAMELLIX, LLC            Topic: NIAID

    AbstractNorovirus is the most common cause of acute gastroenteritis in the United States, associated annually with 19-21 million illnesses, 56,000-71,000 hospitalizations and 570-800 deaths (US CDC, Overview about Norovirus). Norovirus is one of the nonenveloped viruses that are resistant to alcohol sanitization. According to US CDC Guidelines for the Prevention and Control of Norovirus Gastroente ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Microscale Platform for Augmentation of Cell Transduction (MPACT) to Enhance Ex Vivo Gene Transfer

    SBC: EXPRESSION THERAPEUTICS, LLC            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT Recent advances in clinical gene therapy highlight the need for improved lentiviral vectorLVand adenoassociated viralAAVvector manufacture and utilization efficiencies for enhanced therapeutics outcomesExpression Therapeutics in collaboration with Emory University are developing a microfluidicFluidictechnology based solution that overcomes the mass transport and diffusion ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. The Diagnostic Utility of the in-vitro "Provoked" D dimer test in patients with suspected pulmonary embolism

    SBC: AUGDIMER, LLC            Topic: NHLBI

    Project SummaryThe D Dimer assay is the current diagnostic standard to exclude patients of VTE due to its high sensitivityHoweverD Dimer levels are commonly elevated in patients without thromboembolismleading to poor specificity and poor positive predictive valuePPVDue to the lack of a robust diagnostic tool for VTEwe propose a novel advancement upon current DDimer testing which improves specifici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Chemoenzymatic synthesis of a human milk oligosaccharide array for discovery of therapeutic leads

    SBC: VIAMUNE, INC.            Topic: 300

    Project Summary / Abstract: Human milk oligosaccharides (HMOs) are the third largest component of breast milk and have been described to convey developmental benefits to the newborn. HMOs may comprise a wealth of untapped therapeutic opportunities as this unique class of molecules can interact with, and thereby potentially modulate, mediators of inflammation. Unfortunately, investigation into the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)

    SBC: iMacular Regeneration LLC            Topic: NEI

    1. Project Summary Abstract Age related macular degeneration (AMD) is a leading form of irreversible blindness. iMacular Regeneration LLC (iMac Regen) will introduce a novel tissue support structure (macular O-rings or MORs), made from a biocompatible, implantable material (nitinol or nickel-titanium alloy). The surgical device (MOR) will be tested both ex-vivo and in-vivo for proof of concept in ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Large scale preparation of Glycoamino acids (GAAs) for expanded glycopeptides and glycoproteins synthesis

    SBC: CHEMILY, LLC            Topic: 300

    Project summary abstract This proposal is to synthesize and commercialize Fmoc protected glycoamino acidsGAAsin large scaleGlycoproteins have been reported to exhibit a pivotal role in processes as diverse as fertilizationneuronal developmenthormone activitiesimmune surveillanceand inflammatory responsesGAAs are the brick to build all glycopeptides and glycoproteinsThe synthesis of GAAs requires s ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Natural Glycan Array of the Human Milk Glycome

    SBC: Natglycan, LLC            Topic: 300

    In addition to essential nutrients and bioactive antibodies, human milk is unique in providing a rich pool of free- reducing human milk glycans (HMG) that are minimally digested in the upper GI tract and transported intact into the lower intestine, where, they have well-known pre- and probiotic effects and interfere with pathogen attachment by acting as soluble decoy receptors. HMGs also appear in ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. I-Corps for Fischer Imaging's MammoCAT novel slot scanning mammography

    SBC: Fischer Imaging            Topic: NCI

    PROJECT SUMMARY Fischer Imaging has developed MammoCAT, a device for improved mammography using our proprietary Slot Scanning Technology (SST). SST eliminates scattered radiation from the measurement thereby doubling image resolution and contrast using less than half the dose of standard mammography. MammoCAT can be applied to standard planar digital mammography (DM) and to newer mammography techn ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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