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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IN VIVO TOTAL BODY LEAD ANALYSIS BY X-RAY FLUORESCENCE

    SBC: ABIOMED, INC.            Topic: N/A

    THERE ARE AN ESTIMATED 600,000 CHILDREN UNDER SIX YEARS OLD WITH ELEVATED BLOOD LEAD LEVELS AND ONLY 5,000 PER YEAR UNDERGOING TREATMENT; AS YET, NO TECHNIQUE IS AVAILABLE TO MEASURE TOTAL BODY LEAD BURDEN. THIS PROPOSAL DESCRIBES A TECHNIQUE WHICH USES X-RAY FLUORESCENCE IN A TRANSMISSION GEOMETRY TO MEASURE THE TOTAL BODY-BURDEN OF LEAD, IN VIVO, NONINVASIVELY. A SYSTEM USING A GOLD CALIBRATION ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. IMMUNODIRECTABLE MR CONTRAST AGENTS

    SBC: ADVANCED MAGNETICS, INC.            Topic: N/A

    A NUMBER OF SYNTHESES OF SMALL MAGNETIC PARTICLES PERMITTINGTHE COVALENT ATTACHMENT OF ANTIBODIES WILL BE EXAMINED. CHANGES IN MAGNETIC RESONANCE (MR) PROTON RELAXATION AFTER MAGNETIC ANTIBODIES HAVE BOUND TO CELL SURFACE ANTIGENS WILLBE UTILIZED TO DEMONSTRATE THE BINDING OF ANTIBODY (AND MAGNETIC LABEL) TO ANTIGENS. THE MAGNETIC LABELS INVESTIGATED WILL POSESS THE MAGNETIC PROPERTIES OF A CRYSTA ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. 3-D DISPLAY OF VOLUMETRIC DATA UTILIZING ELECTRONIC AND HOLOGRAPHIC DISPLAYS WITH MOTION PARALLAX

    SBC: Aerodyne Research, Inc.            Topic: N/A

    MEDICAL IMAGING SYSTEMS ARE NOW PRODUCING IMAGERY OF SUCH COMPLEXITY THAT THE TRADITIONAL SLICE PRESENTATIONS ARE INSUFFICIENT FOR COMMUNICATING THE INFORMATION TO THE OBSERVER. CURRENT DISPLAY TECHNIQUES, SUCH AS PRODUCING 2-DPROJECTIONS OF 3-D DATA, ARE A STEP IN THE RIGHT DIRECTION. THIS PROGRAM IS CONCERNED WITH DEVELOPING TRUE 3-D DISPLAY SYSTEMS THAT INCLUDE STEREO AND MOTION PARALLAX. SPECI ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. VENTRICULAR FUNCTION MONITOR FOR ACTIVE PATIENTS

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    TO INCREASE THE BASIC UNDERSTANDING OF THE CARDIAC FUNCTION TO IMPROVE TECHNIQUES TO AID IN THE DIAGNOSIS OF HEART DISEASE. WE PROPOSE TO CONDUCT RESEARCH ON AN IMPROVED METHOD OF EVALUATING MYOCARDIAL FUNCTION IN ACTIVE PATIENTS. THIS APPROACH INVOLVES THE USE OF A VERY COMPACT, VESTLIKE INSTRUMENT WHICH USES NUCLEAR MEDICINE TECHNIQUES TO MEASURE THE EJECTION FRACTION OF THE HIGH VENTRICLE ON A ...

    SBIR Phase II 1987 Department of Health and Human Services
  5. NEW 2D SOLID STATE X-RAY DETECTOR FOR BIOMEDICAL RESEARCH

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    TWO DIMENSIONAL X-RAY DETECTORS ARE FINDING INCREASING USE IN DIFFRACTION STUDIES OF BIOLOGICAL MACROMOLECULES, ESPECIALLY WITH THE ADVENT OF HIGH INTENSITY X-RAY SOURCES AND COMPUTER AIDED ANALYSIS SYSTEMS. CURRENTLY AVAILABLE DETECTORS ALL SUFFER FROM PERFORMANCE LIMITATIONS, MAINTENANCE REQUIREMENTS AND/OR EXORBITANT COSTS. THE PROPOSED RESEARCH IS AIMED AT THE DEVELOPMENT OF A LARGE AREA SINGL ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. COMPUTER CONTROLLED COLLIMATORS FOR RADIATION THERAPY

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    ONE OF THE MOST IMPORTANT CRITERIA FOR SUCCESSFUL RADIATION THERAPY IS THE ABILITY TO DELIVER THE HIGHEST POSSIBLE TUMOR DOSE AND MINIMIZE THE DOSE TO NORMAL TISSUE. MOST TECHNIQUES CURRENTLY USED FOR SHAPING RADIATION THERAPY BEAMS INVOLVE THE FABRICATION OF CUSTOM MADE, DENSE ALLOY BLOCKS. WHILE THESE BLOCKS HAVE PROVEN TO BE RELATIVELY EFFECTIVE, THEIR CONSTRUCTION IS VERY LABOR INTENSIVE AND E ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. ENHANCED ON-LINE GEL ELECTROPHORESIS SYSTEM

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    AN UNDERSTANDING OF GENETIC INFORMATION ACHIEVED BY SEQUENCING DNA IS ONE OF THE MOST EXCITING RECENT ADVANCES IN BIOCHEMISTRY. GEL ELECTROPHORESIS IS THE MOST WIDELY USED METHOD TO ACHIEVE THIS IMPORTANT RESULT. TYPICALLY, THE SEPARATION OF THE DIFFERENT MOLECULAR-WEIGHT FRAGMENTS IN THE GEL REQUIRES SEVERAL HOURS, AND THE GEL IS THEN REMOVED FROM THE APPARATUS AND SUBSEQUENTLY ANALYZED TOREVEAL ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. INTRAOPERATIVE, REGIONAL MYOCARDIAL BLOOD FLOW MONITOR

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  9. CELL PANELS FOR TESTING MONOCLONAL ANTIBODIES

    SBC: Asa Rule Inc            Topic: N/A

    OPTIMAL EVALUATION OF MONOCLONAL ANTIBODIES (MAB) FREQUENTLYREQUIRES USE OF QUICK-FROZEN CELLS OR TISSUES NOT READILY AVAILABLE TO RESEARCH AND COMMERCIAL GROUPS. ASA RULE, INC.PLANS TO DEVELOP A RAPID SERVICE TO SCREEN MABS. THIS WILL REQUIRE THE AVAILABILITY OF WELL-ORGANIZED, QUICK-FROZEN PANELS OF NORMAL, BENIGN, AND MALIGNANT CELLS (DISAGGREGATESOR TISSUES) FROZEN AND MAINTAINED AT -80 DEGGEE ...

    SBIR Phase I 1987 Department of Health and Human Services
  10. COMBINED TACTILE AID AND CLASSROOM FM AUDITORY TRAINER

    SBC: AUDIOLOGICAL ENGINEERING CORPORATION            Topic: N/A

    THE LONG-RANGE GOAL OF THIS PROJECT IS TO ENABLE THE IMPLEMENTATION OF A TACTILE FM TRAINER CONSISTING OF AN FM RECEIVER, A FIVE-CHANNEL TACTILE AID, AND A HIGH-GAIN BILATERAL HEARING AID AS AN INTEGRAL UNIT FOR USE BY SEVERELY AND PROFOUNDLY DEAF CHILDREN. THE IMMEDIATE GOALS ARE TO ASSESS THE TECHNOLOGICAL POSSIBILITIES FOR DESIGNING SUCH A UNIT IN AN ACCEPTABLE SIZE, TO VERIFY THE ADEQUACY OF T ...

    SBIR Phase I 1987 Department of Health and Human Services

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