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IN CHEMICAL AND BIOLOGICAL SYSTEMS, IRON IS BOTH UBIQUITOUS AND HIGHLY REACTIVE. IN A VARIETY OF CIRCUMSTANCES, THERE IS GREAT NEED FOR NEW APPROACHES TO THE REMOVAL OF IRON OR THE CONTROL OF ITS REACTIVITY. BIOMEDICAL FRONTIERS HAS PRODUCED A SERIES OF HIGH MOLECULAR WEIGHT IRON CHELATORS BASED ON DERIVATION OF A NUMBER OF SUBSTRATES WITH DEFER- OXAMINE B. THIS CHELATOR HAS AN EXTREMELY HIGH AFFI ...

INTRAOCULAR LENS IMPLANTS HAVE RETURNED VISION TO MANY CATARACT PATIENTS. THESE IMPLANTS PROVIDE VISUAL ACUITY WITHOUT THE DISTORTION OR MAGNIFICATION THAT CAN RESULT FROMWEARING THICK-LENSED SPECTACLES OR CONTACT LENSES. HOWEVER,AS WITH ALL OTHER IMPLANTABLE DEVICES, THERE ARE PROBLEMS WITH THE INTERACTION OF THE SYNTHETIC LENSES WITH EYE TISSUES. INADVERTENT CONTACT BETWEEN THE LENS AND THE CORN ...

SERIOUS ATTENTION HAS BEEN FOCUSED ON THE USE OF ILLICIT DRUGS BY AMERICANS IN ALL WALKS OF LIFE. ONE OF THE MOST ABUSED DRUGS FOR OVER TWO DECADES HAS BEEN MARIJUANA, WHICH IS NOW BEING USED BY BLUE- AND WHITE-COLLAR WORKERS, MILITARY PERSONNEL, PROFESSIONAL ATHLETES, AND HIGH SCHOOL STUDENTS. BECAUSE OF THIS, MANY EMPLOYERS (INCLUDING THE U.S. MILITARY) ARE BEGINNING TO DEMAND THAT WORKERS SUSPE ...

BIO-METRIC SYSTEMS, INC. PROPOSES TO DEVELOP A SEMIQUANTITATIVE, NONLABORATORY ENZYME IMMUNOASSAY THAT IS EXPECTED TO BE SENSITIVE, RAPID, AND CONVENIENT TO USE. THIS IMMUNOASSAY WILL REQUIRE NO INSTRUMENTATION AND IS EXPECTED TO HAVE A SINGLE-STEP PROTOCOL: SIMPLY DIP THE APPARATUS IN THE SAMPLE, WAIT A PRESCRIBED TIME, AND OBSERVETHE RESULT. THE QUANTITY OF ANALYTE PRESENT IN THE TEST SAMPLE IS ...

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UNDER THIS PROPOSED EFFORT, THE FEASIBILITY OF A MULTICHANNEL FM TELEMETRY SYSTEM CAPABLE OF TELEMETERING WIDE-BAND PHYSIOLOGICAL DATA WILL BE STUDIED AND ALTERNATE DESIGNS WILL BE EVALUATED VIA THE CONSTRUCTIUON OF PROTOTYPES. THE SYSTEM WILL INCLUDE A TRANSMITTER CAPABLE OF TELEMETERING SIGNALS FROM COMMONLY USED ELECTRODES AS THE MAJOR FOCUS ON THIS EFFORT, WHILE INTEGRATING COMMERCIALLY AVAILA ...

THE LONG-TERM OBJECTIVE OF THIS WORK IS TO DEVELOP A RAPID, COLORIMETRIC, INSTRUMENT-DEPENDENT ASSAY FOR THEOPHYLLINE CONSTITUENTS. GENESIS LABS' ""IMMUNOSTRIP'' ASSAY (PROTECTED BY PATENT) IS CONSTRUCTED IN A CONFIGURATION THAT IS APPLICABLE FOR THE RAPID DETECTION OF DRUGS AND METABOLITES IN BIOLOGICAL FLUIDS, E.G., URINE, BLOOD, OR SALIVA. THE RELATIVE SIMPLICITY OF THE METHOD SUGGESTS ITS EASY ...

THE AIM OF THIS PROJECT IS TO DEMONSTRATE AN IMMUNOMETRIC ASSAY FOR CANDIDA ANTIGEN (MANNAN) USING ACRIDINIUM ESTERS AS A CHEMILUMINESCENT LABEL. THIS WILL LEAD TO A TECHNIQUE FOR THE DETECTION OF FUNGAL ANTIGENS THAT REQUIRES HIGH SENSITIVITY, BY A METHOD THAT IS SIMPLER, SAFER, AND CHEAPERTHAN CONVENTIONAL METHODS. MONOCLONAL ANTIBODIES TO CANDIDA MANNAN WILL BE PURIFIED AND CHARACTERIZED FOR TH ...

THE AIM OF THIS PROJECT IS TO DEMONSTRATE THE FEASIBILITY OF AN IMMUNOASSAY FOR INSULIN, USING ACRIDINIUM ESTERS AS A CHEMILUMINESCENT LABEL. THIS WILL LEAD TO A TECHNIQUE FOR THE DETECTION OF POLYPEPTIDE HORMONES THAT IS FASTER AND MORE SENSITIVE, AND REMOVES THE NEED FOR (125)I-LABELED PEPTIDES OR ANTIBODIES. THE PROJECT WILL EXPLORE BOTH TRADITIONAL IMMUNOASSAYS IN WHICH THE INSULIN MOLECULE IS ...