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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. AN EFFICIENT METHOD FOR GENERATING FULL-LENGTH CDNA

    SBC: Gold Biotechnology Inc            Topic: N/A

    GOLD BIOTECHNOLOGY, INC. IS STUDYING A NEW METHOD FOR GENERATING FULL-LENGTH CDNA. THIS METHOD SHOULD BE SIMPLE AND EFFICIENT AND THUS ALLOW CLONING OF BOTH RARE AND ABUNDANT MRNA. THIS METHOD IMPROVES UPON OTHER PROCEDURES IN THE FOLLOWING WAYS: (1) NO S1 NUCLEASE IS REQUIRED FOR CLONING CDNA INTO THE VECTOR, AND (2) TAILING OF CDNA IS UNNECESSARY FOR BOTH INSERTION OF THE CDNA INTO THE VECTOR AN ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. ASSAY OF NUCLEOSIDES IN SMALL-CELL CARCINOMA OF THE LUNG

    SBC: Imbic Corpon            Topic: N/A

    SEVERAL INVESTIGATORS HAVE IMPLICATED MODIFIED RIBONUCLEOSIDES, PRESUMABLY MODIFICATION PRODUCTS FROM TRANSFER RIBONUCLEIC ACIDS (TRNAS), AS POTENTIAL BIOLOGICAL MARKERS FOR CANCER. ELEVATED LEVELS OF THESE MOLECULES HAVE BEEN QUANTITATED IN THE SERUM OR URINE OF CANCER PATIENTS BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET (HPLC-UV) OR IMMUNOASSAY. IN THIS PROPOSAL, IMBIC CORPORATION WILL ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. CHARACTERIZATION AND EXPRESSION OF CDNA CLONES ENCODING HUMAN PROTEASE NEXIN

    SBC: Invitron Corp            Topic: N/A

    PROTEASE NEXIN (PN), CDNA CLONES WERE ISOLATED FROM A HUMAN FIBROBLAST LIBRARY USING OLIGOMER PROBES DERIVED FROM THE N-TERMINAL AMINO ACID SEQUENCE OF THE PROTEIN. SEVERAL FULL-LENGTH CLONES WERE CHARACTERIZED AND FOUND TO BE APPROXIMATELY 2,100 BP LONG. THE PN CLONES CONTAINED A 1,260 BP OPEN-READING FRAME THAT DEFINES A 401-AMINO ACID PROTEIN WITH A CHARACTERISTIC LEADER PEPTIDE OF 19 AMINO ACI ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. IMMUNOSORBENT DEVICE FOR LDL REMOVAL FROM WHOLE BLOOD

    SBC: Invitron Corp            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  5. AN ADVERSE REACTION TO A DRUG WHICH TAKES PLACE WHILE A PATIENT IS ON MEDICATION IS OFTEN IMPOSSIBLE TO DIAGNOSE ACCURATELY.

    SBC: Imbic Corpon            Topic: N/A

    AN ADVERSE REACTION TO A DRUG WHICH TAKES PLACE WHILE A PATIENT IS ON MEDICATION IS OFTEN IMPOSSIBLE TO DIAGNOSE ACCURATELY. THE NATURE OF THE UNDERLYING REACTION MAY HAVE AN IMMUNOLOGIC, TOXICOLOGIC, OR PHARMACOLOGIC BASIS. AMONG THE MOST NOTABLE IMMUNOLOGIC REACTIONS TO DRUGS ARE THOSE WHICH GIVE RISE TO ANTIBODIES THAT, IN THE PRESENCE OF DRUG, ATTACH TO BLOOD CELLS AND DESTROY THEM. THE MOST C ...

    SBIR Phase I 1985 Department of Health and Human Services
  6. BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH).

    SBC: Imbic Corpon            Topic: N/A

    BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH). IT HAS BEEN SHOWN TO BE A NATURALLY OCCURRING OPIATE, AS WELL AS TO POSSESS NONOPIATE RELATED BIOACTIVITY. CURRENT ASSAY TECHNIQUES ARE INADEQUATE DUE TO LACK OF IMMUNOLOGICAL SPECIFICITY RESULTING FROM CROSS-REACTING OF BE AND BLPH WITH THE SAME ANTIBODIES. A SEPARATION METHOD UTILIZING THE S ...

    SBIR Phase I 1985 Department of Health and Human Services
  7. THE FORMATION OF DNA-CARCINOGEN ADDUCTS IS AN IMPORTANT ENVIRONMENTAL FACTOR IN CARCINOGENESIS.

    SBC: Imbic Corpon            Topic: N/A

    THE FORMATION OF DNA-CARCINOGEN ADDUCTS IS AN IMPORTANT ENVIRONMENTAL FACTOR IN CARCINOGENESIS. RECENT TECHNIQUES FOR ISOLATION AND CHARACTERIZATION OF DEOXYNUCLEOSIDE-CARCINOGEN ADDUCTS AND SUBSEQUENT IMMUNOASSAY PROCEDURES CAN EFFECTIVELY DETECT THESE ADDUCTS FROM CELL LYSATES IN THE RANGE OF 1 ADDUCT/107 BASES. WE WILL USE OUR COMBINED TECHNICAL EXPERTISE IN THE AREAS OF NUCLEOTIDE/NUCLEOSIDE C ...

    SBIR Phase I 1985 Department of Health and Human Services
  8. A MODEL SYSTEM IS CREATED TO DETERMINE THE FEASIBILITY OF DEVELOPING INTEGRATED COMPUTER SOFTWARE FOR ANATOMIC PATHOLOGY MANAGEMENT INFORMATION.

    SBC: Management Tech Consult Inc.            Topic: N/A

    A MODEL SYSTEM IS CREATED TO DETERMINE THE FEASIBILITY OF DEVELOPING INTEGRATED COMPUTER SOFTWARE FOR ANATOMIC PATHOLOGY MANAGEMENT INFORMATION. THE SOFTWARE COMBINES SEVERAL UNIQUE DIAGNOSTIC CODING FUNCTIONS, IS TRANSPORTABLE TO THE MAJOR COMPUTER ARCHITECTURES, AND IS EFFICIENT THE OBJECTIVES ARE TO: 1. INTEGRATE APPLICABLE PATIENT INFORMATION OBTAINED AUTOMATICALLY FROM HOSPITAL SOURCES DIRECT ...

    SBIR Phase I 1985 Department of Health and Human Services
  9. THE SPECIFIC AIM OF THIS RESEARCH PROJECT IS TO DEVELOP A METHODOLOGY WHICH INCORPORATES TECHNOLOGICAL INNOVATIONS TO ENHANCE THE PERFORMANCE OF THE HOME HEALTH NURSE IN PROVIDING CARE FOR THE ELDERLY IN THEIR OWN HOME.

    SBC: NU-VISION, INC.            Topic: N/A

    THE SPECIFIC AIM OF THIS RESEARCH PROJECT IS TO DEVELOP A METHODOLOGY WHICH INCORPORATES TECHNOLOGICAL INNOVATIONS TO ENHANCE THE PERFORMANCE OF THE HOME HEALTH NURSE IN PROVIDING CARE FOR THE ELDERLY IN THEIR OWN HOME. PHASE I WILL CULMINATE IN 1.THE DEVELOPMENT OF A DATA COLLECTION INSTRUMENT FOR THE IDENTIFICATION OF THE LEARNING NEEDS AND LEARNING STYLE PREFERENCE FOR THE HOME HEALTH NURSE; 2. ...

    SBIR Phase I 1985 Department of Health and Human Services
  10. TECHNOLOGICAL INNOVATION FOR HOME HEALTH CARE NURSING

    SBC: NU-VISION, INC.            Topic: N/A

    N/A

    SBIR Phase I 1985 Department of Health and Human Services

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