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PROJECT SUMMARYABSTRACT TitleAccelerating Site specific Characterization of Protein Therapeutics with Novel Machine Learning Methods The project seeks to improve reliability and speed up the development of life saving and life enhancingprecisionprotein therapeutics and magnify the positive impact of biomedical research and education worldwideleading to a quantum leap in our understanding of the mo ...

RECENT IMPROVEMENTS IN IMPLANTABLE PHYSIOLOGICAL TRANSDUCER TECHNOLOGY AND THE AVAILABILITY OF LOW-COST COMPUTATIONAL POWER HAVE GREATLY INCREASED INTEREST IN THE AUTOMATED CONTROL OF PHYSIOLOGICAL PARAMETERS IN THE RESEARCH LABORATORY AND IN CLINICAL THERAPY. THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP AND EVALUATE SAFE AND EFFECTIVE ADAPTIVE CONTROL SOFTWARE FOR THE AUTOMATIC REGULATION OF THER ...

Magnetic resonance imagingMRIis a safenon ionizing diagnostic toolThe overall goal of this project is to arrive very close to the ultimate intrinsic signal to noise ratioUISNRfor a given MRI magnet field strength by combining innovations in very advanced transceiver technologyIn Phase Ia high performance head RF coil receiver array will be prototyped and SNR performance compared to an existing com ...

Abstract Diabetic macular edemaDMEis the leading cause of vision loss in the working age population whichconsidering the worldwide epidemic of diabetesrepresents a growing socioeconomic challengeDME is characterized by the destabilization of retinal blood vessels resulting in the accumulation of fluid in the maculathe area of the retina responsible for central visionThe current standard of care fo ...

Project Summary AbstractBreast cancer is the most common cancer in womenwith a projectedcasesand more thandeathsin the US duringDue to better screening techniques cancers are caught earlier andof patients are candidates for breast conserving surgeryBCSto remove the cancerBCS is cosmetically preferable to the alternativemastectomyand long term survival rates are equivalentThe success of BCS is asse ...

Project Summary Abstract The goal of this project is to complete the pre clinical and translational studies necessary to prepare a novel oncolytic viralOVtherapyWO Sfor clinical evaluation in non small cell lung cancerNSCLCNSCLC is the predominate form of lung cancerwhich is the leading cause of cancer death in the United StatesRecentlyimmunotherapies have emerged as a potential new treatment appr ...

Abstract This direct SBIR Phase II project aims to develop a novel technology and associated assays for efficiently and robustly extracting circulating miRNAs from blood (i.e. plasma or serum), which could transform the utility of miRNA testing in the diagnosis and monitoring of major diseases such as cancer and cardiovascular disease. Our competitive advantage lies in the ability to retrieve circ ...

Project Summary Abstract Infection with Human Immunodeficiency VirusHIVaffects an estimatedmillion worldwideIn the United Statesan estimatedmillion people are infectedAs the access to antiretroviral treatmentARThas increasedthe population of people infected with HIV live longerPatients with viral suppression have increased life expectancyHowevercompare to age matched individual without HIV infecti ...

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predic ...

Abstract Summary In this SBIRwe propose to validate our handcrafted image analysis algorithm for auto detecting Mycobacterium tuberculosisMTBin a digitized sputum smearOnce validated in a blinded study against manual microscopy and culturethe gold standardwe will try to improve our handcrafted algorithm by integratingwhere appropriatedeep learning approachesvia Convolutional Neural NetworksCNNOur ...