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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: Oculo Therapy, LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the worldElevated intraocular pressureIOPis the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucomathe most common form of glaucomaThe current standard of care for glaucoma includes IOPlowering medications delivered topically as eye dropswhich decrease the vol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Identifying the precursor to oxytocin-induced uterine tachysystole by monitoring with uterine EMG

    SBC: PreTel, Inc.            Topic: NICHD

    Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Expanding the Tool Box: Environmental Metabolomics Improves Decision Making and Management of Contaminated (Superfund) Sites

    SBC: Microbial Insights, Inc.            Topic: NIEHS

    Project Summary Abstract Metabolomics is a relatively novel Molecular Biological ToolMBTwhich employs highly sensitive instrumentation to obtain a measure of all small organic molecules present in a biological sampleContemporary MBTs rely on quantitative PCR and measure the presence and abundance of keystone bacteriae gDehalococcoidesinvolved in the detoxification of priority contaminants such as ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Enabling dexterous surgery at the tip of a flexible endoscope: A low-cost, disposable, steerable sheath.

    SBC: EndoTheia, Inc.            Topic: NIBIB

    Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Fully Human Antibody Combinations for the Prevention of Seasonal Influenza Infection

    SBC: IDBiologics, Inc.            Topic: NIAID

    Our overarching goal is to develop a monoclonal antibody based product for the prevention of seasonal influenza in high risk patientsIt is estimated there aredeaths annually related to seasonal influenza worldwideIn the United Statestheinfluenza season was classified a high severity season withdeathsandhospitalizations attributed to influenzaserving as a reminder of the continued severity of influ ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Mobile-phone integrated rapid diagnostic tests to improve antibiotic stewardship

    SBC: PragmaDx, Inc.            Topic: NIAID

    PROJECT SUMMARYAn estimatedbillion antibiotic prescriptions were filled in the US fromDespite a national antibiotic education campaignapproximatelyof antibiotic prescriptions are unnecessaryAs a result of the over prescription of antibioticsthere is a current and pressing public health need for improved antibiotic stewardshipCompounding this problem are new modalities of healthcare like telemedici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a dual MDM2/XIAP inhibitor with a high therapeutic index for childhood cancers

    SBC: SEAK Therapeutics, LLC            Topic: 102

    PROJECT SUMMARYAcute lymphoblastic leukemiaALLand neuroblastomaNBare the most common cancers in childrenCurrently treatment options are often associated with severe side effectsThereforethere is a strong unmet medical need to develop targeted drugs with higher therapeutic indexes for improved treatment outcomeThe oncoproteins MDMand XIAP are important cell survival proteins in tumorsElevated MDMan ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. SBIR Phase I: Evaluating the feasibility of the TotalTHM-NOW for drinking water treatment plants to improve water quality, reduce costs, and lower cancer risks

    SBC: Foundation Instruments, Inc.            Topic: NIEHS

    PROJECT SUMMARY ABSTRACT Research has suggested that there is an increased risk of cancer associated with long term exposure to drinking water containing halogenated disinfection by productsDBPsTrihalomethanesTHMsare the most common class of halogenated DBPs formed during water chlorinationEvery yearthousands of drinking water treatment plantsWTPsstruggle with THMs compliance issues often allocati ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Preventing Neurovascular Matrix Degradation and Hemorrhage in Acute Ischemic Stroke

    SBC: Translational Sciences Inc.            Topic: NHLBI

    Seventeen million people each year suffer from an ischemic stroke and millions are left dead and disabledTreatment with recombinant tissue plasminogen activatorr tPAis only modestly effective at reducing disability and it is associated with brain hemorrhage in up toof patients when serial imaging studies are performedBrain hemorrhage causes death and disability andis the major cause of early morta ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Fully Human Antibodies for the Prevention of Respiratory Syncytial Virus

    SBC: IDBiologics, Inc.            Topic: NIAID

    The goal of this STTR is to provide a preclinically validated monoclonal antibody or antibody combination for the prevention of respiratory syncytial virusRSVin high risk patients including infants and the elderlyWorldwideof children are infected with RSV before the age ofresulting in an estimatedmillion lower respiratory tract infectionsIn the United States adults overhavemillion RSV infections c ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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