Award Data

Development of an agile device that can deliver supplies to and from remote locations during public health emergenciesIn the context of emergency public health responsedrones could be extremely useful for transporting necessary supplies to remote or inaccessible locationsSupplies might include dry goodsbut would certainly include clinical specimensreagent kitsvaccines and other perishable goodsThe ...

The purpose of this proposal is to develop an automated Auditory Brainstem ResponseABRbased neurological screening device and software module that will enhance the early detection of autism and other neurological conditionsAutism Spectrum DisordersASDhave an incidence rate ofBased onmillion births in the United States innew cases of ASD will be diagnosed from that birth cohort aloneThe practice of ...

Glaucoma is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) is the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucoma, the most common form of glaucoma. The current standard of care for glaucoma includes IOP- lowering medications delivered topically as eye drops, which de ...

PROJECT SUMMARY Genomic instabilityinduced by DNA damageand partly mitigated by DNA repair and antioxidantsplays a critical role in the pathogenesis of many major human diseasessuch as neurodegenerationcancer and cardiovascular diseasetogether with agingThere is a critical need for automated assays that can perform these assessmentsand bring them into greater routine usewhich will help advance our ...

Leadless cardiac pacemakersLCPsrepresent a revolutionary leap forward in cardiac pacing technology via its circumvention of transvenous leadsCurrent LCP lithium CFX batteries arecc resulting in an overallcc LCP deviceThis Phase I effort will demonstrate the feasibility of acc betavoltaic battery for LCPs with ayear lifetimex lifetime of current LCP batteriesenabling LCPs with a volumetric size ofc ...

PROJECT ABSTRACTThe electroencephalogramEEGis a sensitive and well established tool for detecting disturbances in brain functionEEG recordingseven as brief as just a few minutescan potentially provide useful information for patients with neurological or neuropsychiatric disordersHowevermost patient care settings are not able to offer EEG services due to the lack of equipment or personnel with the ...

Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

PROJECT SUMMARYHuman embryonic stem cellshEScrepresent a potentially unlimited supply of tissues for regenerative therapiesHowevercurrent differentiation methods result in heterogeneous populations of cells in which the desired product isat besta fraction of the totalMoreovercarry over undifferentiated cellsas well as cells that de differentiate upon transplantationhave been shown to form teratoma ...

Pathological cardiac remodeling constitutes a common pathway to heart failure in diseaseDespite current pharmacologic therapy and other advances that attenuate remodelingmortality due to heart failure remains highNewmore effective therapeutic options are desperately needed in an increasing patient population to improve both the survival and quality of life for patients with or susceptible to heart ...

ABSTRACT Fungal keratitisprimarily caused by CandidaFusariumor Aspergillus speciesis a leading cause of blindness among corneal diseasesAmphotericin BAmBremains the gold standard in the treatment of Candida keratitis and is also the fallback option for other corneal fungal infectionsAlthough widely used off label in ocular infectionsophthalmic AmB formulations are not available commerciallyThe com ...