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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. TOPIC 393: BREATH TEST FOR BIOMARKERS OF RADIATION EXPOSURE

    SBC: MENSSANA RESEARCH INC            Topic: NCI

    The problemPatients receiving therapeutic radiation are at risk of adverse toxic effectsThese adverse events are usually unpredictable and may result in severe morbidity or mortalityExampleA third or more of patients receiving chest radiation for cancers of lung may develop life threatening acute radiation pneumonitisThe clinical needThere is a clinical need for an objective test to estimate the b ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: Oculo Therapy, LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the worldElevated intraocular pressureIOPis the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucomathe most common form of glaucomaThe current standard of care for glaucoma includes IOPlowering medications delivered topically as eye dropswhich decrease the vol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Optimal channel and lever sampling of duodenoscopes for culture using portable Two-Phase Flow technology

    SBC: Novaflux Inc.            Topic: NIAID

    Project Summary Abstract Outbreaks associated with contaminated duodenoscopes are still occurring at high ratesRecent clinical studies evaluating patient used endoscopes reported that culture endoscope contamination rates range from andltup toExperts now recognize that there is an urgent need for an inexpensive and highly reliable sampling method to check on the adequacy of reprocessing duodenosco ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Framework for Biomolecular Optimization and Design Using a New Poisson-Boltzmann Description

    SBC: Continuum Dynamics Inc            Topic: 400

    Rational drug design holds the potential for developing more effective drugs in shorter time frames than traditional trial and error approachesAccordinglysoftware tools are needed that automate the search process and can computationally direct the changes in ligand geometry and charge distribution to selectively bind at specified receptor sitesSuch analysis entails two componentsa module that eval ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a novel therapy for mitigation of the irradiation-inducedgastrointestinal syndrome

    SBC: BioIncept, LLC            Topic: NIAID

    Accidental radiation exposure as a result of terrorismindustrial accidentsor military actions is an increasing global threatExposure to IR in the dose range ofGy andGy toGy results in development of the hematopoieticHand gastrointestinalGIsubsyndromesrespectivelyof the acute radiation syndromeARSThe GI syndrome that follows GI ARS is the leading cause of death following higher doses of radiation e ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Tactile and ultrasound imaging fusion for functional assessment of the female pelvic floor

    SBC: Advanced Tactile Imaging, Inc.            Topic: NICHD

    SUMMARY Pelvic organ prolapsePOPis a highly prevalent condition affecting at leastof women in the US during their lifetimesUrinary incontinenceUIas found in the US surveyaffects fromtoof womenThe true etiology of POP and UI and variations seen among individuals are not entirely understoodThese disorders are thought to share a common pathogenesisweakeningelasticity changesof the muscular and connec ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Novel fluorescent biosensors to continuously visualize real-time protein phosphorylation in live cells

    SBC: Lucidicor Inc.            Topic: 400

    Project SummaryProtein phosphorylation plays an essential role in orchestrating the myriad aspects of cell functionKinaseswhich phosphorylate proteinsare encoded byof the human genome and are critically involved in diverse conditions such as cancermetabolic disorders and neurodegenerationCurrent scientific tools for detecting cellular phosphorylation are limitedbecause most tools examine this proc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. The use of selective NaV1.7 inhibitors to treat inflammation post-surgery

    SBC: CHROMOCELL CORPORATION            Topic: NIAID

    ABSTRACTNonsteroidal anti inflammatory drugsNSAIDsare the most commonly prescribed drugs to treat posttraumatic inflammation and painalthough they carry significant risk of seriousdose dependent adverse eventsCorticosteroidswhich are an alternative class of anti inflammatory drugsare rarely prescribed for post traumatic inflammationdue to adverse effects on wound healing and their lack of specific ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Identifying the precursor to oxytocin-induced uterine tachysystole by monitoring with uterine EMG

    SBC: PreTel, Inc.            Topic: NICHD

    Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Mobile Respiratory Aid Device To Help COPD Patients Breath Easy Again

    SBC: RightAir LLC            Topic: NHLBI

    More thanmillion Americans have such severe COPDchronic obstructive pulmonary diseasethat they cannot even climb a single flight of stairsdue to the feeling of suffocation with even minimal movementThese patients suffer like this for yearsfirst becoming essentially home boundthen chair boundand eventually bed boundThis lack of physical activity has been repeatedly shown to increase the frequency o ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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