Award Data

This project develops Take on Training by Attainment, an application (app) that provides comprehensive instruction to job coaches and direct service workers (DSWs) to increase the independence of individuals with disabilities, maximize their independence on the job site, achieve advancement, and promote sustained employment. The goal for Take on Training by Attainment is to research and develop a ...

Oncology drugs continue to advance at a rapid pace with many therapies delivered orally as tablets or capsulesSmaller childrenhowevercannot swallow tablets or capsulesFor these drugs to be used in the pediatric population they need to be reformulatedTraditionally this has meant creating a liquid suspensionchewableor rapid dissolve tabletCancer medicationshoweveroften have terrible taste profiles t ...

The problemPatients receiving therapeutic radiation are at risk of adverse toxic effectsThese adverse events are usually unpredictable and may result in severe morbidity or mortalityExampleA third or more of patients receiving chest radiation for cancers of lung may develop life threatening acute radiation pneumonitisThe clinical needThere is a clinical need for an objective test to estimate the b ...

This project researches and develops a mobile application (app), Take on Training, to provide direct services workers (DSWs), including job coaches, with on-demand instruction by way of short vignettes to promote the maximum level of independence for people with disabilities at work. Objectives for this Phase II project are to produce a commercially available, mobile, cross-platform app for job co ...

Abstract The Specific Aim of this Phase IIb (Phase II competitive renewal) SBIR proposal is to advance the prototypes we developed under our Phase I and II SBIR grants into commercial production. We will produce SBS-96 format radiation sterilizable electronically tagged sample vials that can be read at ultra-low temperatures. Hundreds of millions of SBS-96 vials are sold each year and each of thes ...

Glaucoma is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) is the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucoma, the most common form of glaucoma. The current standard of care for glaucoma includes IOP- lowering medications delivered topically as eye drops, which de ...

Project Summary Abstract Outbreaks associated with contaminated duodenoscopes are still occurring at high ratesRecent clinical studies evaluating patient used endoscopes reported that culture endoscope contamination rates range from andltup toExperts now recognize that there is an urgent need for an inexpensive and highly reliable sampling method to check on the adequacy of reprocessing duodenosco ...

Project Summary/Abstract Rush River Research (RRR) Corporation proposes to develop and commercialize a novel passive exoskeleton that helps young children with very little residual strength to use their arms. The proposed orthosis could help the over 500,000 children with many different neuromuscular disorders including muscular dystrophy, spinal muscular atrophy, cerebral palsy, arthrogryposis mu ...

Rational drug design holds the potential for developing more effective drugs in shorter time frames than traditional trial and error approachesAccordinglysoftware tools are needed that automate the search process and can computationally direct the changes in ligand geometry and charge distribution to selectively bind at specified receptor sitesSuch analysis entails two componentsa module that eval ...

Accidental radiation exposure as a result of terrorismindustrial accidentsor military actions is an increasing global threatExposure to IR in the dose range ofGy andGy toGy results in development of the hematopoieticHand gastrointestinalGIsubsyndromesrespectivelyof the acute radiation syndromeARSThe GI syndrome that follows GI ARS is the leading cause of death following higher doses of radiation e ...