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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Protein therapeutic to facilitate healing of chronic wounds.

    SBC: TRIM-EDICINE, INC.            Topic: 300

    Project Summary This proposal builds upon the advances from the SBIR Phase I programRGMtargeting the development of recombinant human MGrhMGa novel tissue repair proteinas a topical therapeutic agent to facilitate healing of chronic woundsWound care represents a challenging problem to the public healthas no effective treatments for chronic non healing wounds are availableMGis an essential componen ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Autoscreen: An innovative e-health solution for early identification of Autism Spectrum Disorder Phase II

    SBC: Adaptive Technology Consulting, LLC            Topic: NIMH

    PROJECT SUMMARY Early accurate identification and treatment of young children with Autism Spectrum DisorderASDrepresents a pressing public health and clinical care challengeGiven mounting evidence that earlyaccurate diagnosis of ASD is possible and that very young children who receive intervention can demonstrate substantial gains in functioningcurrent American Academy of Pediatrics practice guide ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Multifunctional Semi-Powered Ankle Prosthesis: Phase II

    SBC: Synchro Motion LLC            Topic: NICHD

    PROJECT SUMMARY A conventional prosthetic ankle consists of a carbon fiber ankle foot complex that is nominally configured to a neutral positionThese prostheses generally work well for level walking and level ground standingbut lack the adaptability to explicitly accommodate other terrain or locomotion activitiessuch as slope walkingslope standingand stair ambulationAs suchcommon activities with a ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter

    SBC: Tom L Merrill            Topic: 101

    Project Summary Stroke is theth leading cause of death and number one cause of adult disability in the United StatesThe primary goal of acute ischemic strokeAIStreatment is quickly restoring blood perfusionHoweverstudies have shown that this return of blood flowwhile necessarycan also cause damage to local tissue leading to poor patient outcomesTherapeutic hypothermiaTHhas been shown to be a robus ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Performance Evaluation of a non-Degradable Synthetic Device for Chondral and Osteochondral Defects of the Knee

    SBC: Hydro-Gen LLC            Topic: NIAMS

    Injury to joints can lead to painful defects in articular cartilage and the underlying bonewhich adversely affect the function and biological health of the entire jointCurrent solutions for cartilagechondraland cartilage andboneosteochondraldefectsare unreliableare technically challengingand often require multiple proceduresA surgeon engineer biologist team at Hospital for Special SurgeryHSSdedica ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. 3D-Printed Superhydrophobic-Tipped Optical Fiber for Targeted Periodontal Photodynamic Therapy

    SBC: SingletO2 Therapeutics LLC            Topic: NIDCR

    Project Summary Abstract Eradication of bacteria located in periodontal pockets presents a daunting challenge to dentists and oral care professionalsThe problem is significantsevere periodontitis is theth most prevalent disease worldwide with overmillion people affectedThe global cost of lost productivity from severe periodontitis is estimated to be $billion USD yearAntibiotics with scaling and ro ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Reopening the Central Airway With Needle-Size Tentacle Manipulators

    SBC: Virtuoso Surgical, Inc.            Topic: NHLBI

    Project Summary AbstractThe objective of this proposal is to create a new surgical device that provides dexterity at the tip of a rigid bronchoscopeOur new system will deliver needle sizedtentacle like arms through the bronchoscope portenabling independent tissue manipulationlaserber aimingand visualizationwhich we hypothesize will make central airway obstruction surgery safermore effectiveand mor ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCs

    SBC: 490 BIOTECH INC            Topic: NIEHS

    Expanding the throughput of real time toxicological screening of cardiac differentiation byexpressing a synthetic luciferase luciferin genetic pathway in iPSCs Project Summary This Small Business Innovation ResearchSBIRPhase II project proposes to develop and validate autonomously bioluminescent induced pluripotent stem cellsiPSCsfor use in continuously data producingreagent freeand real time toxi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a novel agent to treat antimicrobial resistant Neisseria gonorrhoeae

    SBC: Prokaryotics, Inc.            Topic: R

    The WHO estimates gonorrhea infections occur inmillion people globally every yearThe extensive spread of antimicrobial resistant Ng has prompted the CDC to designate it as an Urgent Threat pathogenAlarminglyresistance is now emerging to the remaining current standard of careSOCdual therapy of ceftriaxoneCROand azithromycinAZMDespite this global health crisisfew new therapeutic agents are currently ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Feasibility of a mobile parent-based intervention to reduce alcohol use by highschool seniors

    SBC: Real Prevention LLC            Topic: 350

    The goal of this Phase II SBIR is to provide an efficientengagingand effective means to enhance parentsability to reduce prevalence of alcohol use and consequencesand other substance use through the development and evaluation of Parenting NowPNPN is a briefinteractiveself pacedand digital curriculum for parents of high school aged adolescentsa frequently neglected population created from the evide ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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