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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. WRIST ACTIVITY MONITORING FOR OUTPATIENT BEHAVIOR

    SBC: AMBULATORY MONITORING, INC.            Topic: N/A

    MOTOR EVENT FREQUENCY RECORDING, ACTIGRAPHY, IS A TECHNOLOGY USEFUL IN STUDIES OF SLEEP DISORDERS, CIRCADIAN FUNCTION, ACTIVITY PATTERNS OF ADULTS AND INFANTS, AND DEPRESSIVE DISORDERS. WIDESPREAD UTILIZATION OF THIS MONITORING TECHNOLOGY IN HEALTH APPLICATIONS HAS BEEN DELAYED BY THE LACK OF AN AFFORDABLE ACTIVITY MONITORING INSTRUMENT AND INTEGRATED SYSTEM FOR DATA MANAGEMENT, ANALYSIS, AND PRES ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. DEVELOPMENT OF A CONTROLLED-ENVIRONMENT CHAMBER

    SBC: American Boremene Inc            Topic: N/A

    THE LONG-TERM OBJECTIVE IS TO DEVELOP A MECHANICAL DEVICE THAT WILL PROVIDE COMPLETE ENVIRONMENTAL CONTROL (TEMPERATURE, PRESSURE, HUMIDITY, STERILITY, PH, GASEOUS ATMOSPHERE, AND LIGHT RAYS) OF BIOLOGICAL OR INDUSTRIAL SPECIMENS UNDER MICROSCOPIC EXAMINATION. CONTROLS WILL BE MAINTAINED EVEN DURING PERIODS OF PHYSICAL MANIPULATION OF THE SPECIMEN AND DURING MICROSCOPIC OBSERVATION THROUGH OPTICAL ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. DEVELOPMENT OF A CONTROLLED-ENVIRONMENT CHAMBER

    SBC: American Boremene Inc            Topic: N/A

    THE LONG-TERM OBJECTIVE IS TO DEVELOP A MECHANICAL DEVICE THAT WILL PROVIDE COMPLETE ENVIRONMENTAL CONTROL (TEMPERATURE, PRESSURE, HUMIDITY, STERILITY, PH, GASEOUS ATMOSPHERE, AND LIGHT RAYS) FOR BIOLOGICAL OR INDUSTRIAL SPECIMENS UNDER MICROSCOPIC EXAMINATION. CONTROLS WILL BE MAINTAINED EVEN DURING PERIODS OF PHYSICAL MANIPULATION OF THE SPECIMEN AND DURING MICROSCOPIC OBSERVATION THROUGH OPTICA ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. POCKET NEBULIZER

    SBC: Amnis Corporation            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  5. DEVELOPMENT OF PROTEASE-DEFICIENT, GRAM-POSITIVE HOST

    SBC: Applied Microbiology Inc            Topic: N/A

    OUR LONG-TERM AIM IS TO DEVELOP A GRAM-POSITIVE ORGANISM FORTHE EXPRESSION AND SECRETION OF MEDICALLY AND INDUSTRIALLY USEFUL PROTEINS. ONE MAJOR OBSTACLE TO THE SUCCESSFUL DEVELOPMENT OF SUCH A SYSTEM IS THE PROTEOLYTIC DEGRADATION OF SECRETED PRODUCTS. SITE-DIRECTED DELETION MUTATIONS CONSTRUCTED IN VITRO HAVE ELIMINATED THE TWO MAJOR EXTRACELLULAR PROTEASES OF B. SUBTILIS. ALTHOUGH SIGNIFICANTL ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. NEONATAL NUTRITION AND RESONANCE IONIZATION SPECTROSCOPY

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    A PAUCITY OF KNOWLEDGE EXISTS ABOUT NEONATAL TRACE ELEMENT NUTRITION REQUIREMENTS, ESPECIALLY FOR PREMATURE INFANTS, WHOSE CRITICAL FINAL TRIMESTER ACCUMULATION OF ESSENTIAL TRACE ELEMENTS IS ABRUPTLY CEASED AT BIRTH. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE SCIENCE AND TECHNOLOGY "BRIDGE" REQUIRED TO DEMONSTRATE THE FEASIBILITY OF DIRECT, OR NEARLY DIRECT, DETERMINATION BY RESONANCE IONIZ ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. TRACE CHROMIUM IN DIABETES USING RESONANCE IONIZATION

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    TRACE ELEMENT NUTRITURE IS INCREASINGLY ACKNOWLEDGED AS A KEY ASPECT OF GROWTH, DEVELOPMENT, AND HEALTH. TRACE CHROMIUM MAY BE RELATED TO REGULATION OF INSULATION ACTION, RESTORATION OF IMPAIRED GLUCOSE TOLERANCE, AND THE CAUSAL

    SBIR Phase I 1987 Department of Health and Human Services
  8. IMAGING OF ELEMENTS IN TISSUE AT TRACE CONCENTRATIONS

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    INSTRUMENTATION ENABLING QUANTITATIVE TRACE ELEMENT-CONCENTRATION IMAGING WITH HIGH SENSITIVITY AND RESOLUTION (1 PPM, 5 ) OF BIOLOGICAL TISSUE SECTIONS OVER 2X2MM(2) WOULD BE A VALUABLE RESEARCH TOOL. SIMULTANEOUS STRUCTURAL IMAGING WOULD ENHANCE ITS UTILITY. SPUTTER-INITIATED RESONANCE IONIZATION SPECTROSCOPY (SIRIS) WILL BE ADAPTED TO PROVIDE STRUCTURAL IMAGING AND QUANTITATIVE ELEMENT-CONCENTR ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. SUBPICOSECOND DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    EMERGING HEALTH AND MEDICAL RESEARCH PROBLEMS ARE PLACING STRINGENT REQUIREMENTS ON THE ABILITY TO CHARACTERIZE LABILEAND HIGH-MOLECULAR-WEIGHT ORGANIC COMPOUNDS. IN BIOTECHNOLOGY, FOR EXAMPLE, INTERMEDIATE SYNTHESIS PRODUCTS MUST BE IDENTIFIED. RECENT ION BOMBARDMENT DESORPTION MODELS SUGGEST THAT HIGHEST-MOLECULAR-WEIGHT COMPOUNDS WOULDDESORB MOST EFFICIENTLY THROUGH RAPID, MULTIPLE EXCITATIONS ...

    SBIR Phase I 1987 Department of Health and Human Services
  10. CHROMIUM DEFICIENCY IN INSULIN RESISTANCE

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services

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