Award Data

The SBIR Fast-track develops, tests, and commercializes the ‘Active Disposable Cap for Endoscope (ACE) Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps.’ The disposable system includes a distal-connecting cap, allowing a clinician to manipulate tissue and perform targeted aspiration during complex polypectomies using proximal controls, without occupying th ...

PROJECT SUMMARY Novel therapies for the treatment of chikungunya virus (CHIKV) infections are urgently needed to address the alarming spread of this pathogen across the Americas. We have identified three distinct series of potent, selective, and orally bioavailable inhibitors of CHIKV replication. In this Phase II renewal SBIR project, we will optimize these series of CHIKV inhibitors to Pre-Devel ...

There is a critical gap in the reliability of anisotropic diffusion magnetic resonance imaging (AdMRI). This gap can be filled by using a ground truth measurement capability that allows for the necessary parametric control of water filled geometries of tubes at the micron scale that can produce paths representative of the millions of axons across centimeters in brain tract trajectories. Diffusion ...

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PROJECT SUMMARY ABSTRACT Vocal fold paralysisVFPoccurs when the recurrent laryngeal nerveRLNis injuredmost commonly during surgery of the neckBilateral injury to the RLN can result in potentially life threatening airway obstruction and the need for tracheostomyThe RLN can regenerate some of its axonsbut in many patients with paralysis some form of intervention is required to correct the airway obs ...

Abstract. Melanoma is the third most common form of skin cancer with estimated 87,110 new cases diagnosed in the United States in the year 2017. Current routine diagnostic approaches utilize microscopic evaluation of thinly sectioned patient biopsies, but in certain cases diagnosis can be contentious even among experts. The overall goal of this multi-phase SBIR project is to develop, validate, and ...

Abstract Alzheimer s diseaseADis a progressivedisabling neurodegenerative illness that affects an estimatedmillion people in the United States and approximatelyof the population over the age ofEarly symptoms of the disease include short term memory lossdifficulties with languageand mood swingshoweversymptoms gradually worsen over timeultimately leading to dementia and a loss of bodily functionsSig ...

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Project Summary AbstractTraumatic Brain InjuryTBIcontributes to a third of injury related deaths in the US and is among the leading causes of death and disability in people underand overRecent statistics show that TBI annually causesdeathshospital admissionscarries an average lifetime expense of $patientand an annual economic burden conservatively estimated at $billionThe lack of any approved drug ...

A NEW TWO-DIMENSIONAL POSITION ENCODER IS PROPOSED FOR PET WITH POSITION RESOLUTION BETTER THAN 3 MILLIMETERS. THE NEW DETECTOR INCLUDES 32 BISMUTH GERMANATE (BGO) SCINTILLATION CRYSTALS MOUNTED ON A LIGHT GUIDE. THE LIGHT GUIDE PROVIDES A SQUARE ROOT SEPARATION OF THE LIGHT DISTRIBUTION FROM EACH CRYSTAL. THE LIGHT FROM THE LIGHT GUIDE IS DETECTED BY TWO DUAL HAMAMATSU PHOTOMULTIPLIER TUBES (R154 ...