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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. NEONATAL NUTRITION AND RESONANCE IONIZATION SPECTROSCOPY

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    A PAUCITY OF KNOWLEDGE EXISTS ABOUT NEONATAL TRACE ELEMENT NUTRITION REQUIREMENTS, ESPECIALLY FOR PREMATURE INFANTS, WHOSE CRITICAL FINAL TRIMESTER ACCUMULATION OF ESSENTIAL TRACE ELEMENTS IS ABRUPTLY CEASED AT BIRTH. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE SCIENCE AND TECHNOLOGY "BRIDGE" REQUIRED TO DEMONSTRATE THE FEASIBILITY OF DIRECT, OR NEARLY DIRECT, DETERMINATION BY RESONANCE IONIZ ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. TRACE CHROMIUM IN DIABETES USING RESONANCE IONIZATION

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    TRACE ELEMENT NUTRITURE IS INCREASINGLY ACKNOWLEDGED AS A KEY ASPECT OF GROWTH, DEVELOPMENT, AND HEALTH. TRACE CHROMIUM MAY BE RELATED TO REGULATION OF INSULATION ACTION, RESTORATION OF IMPAIRED GLUCOSE TOLERANCE, AND THE CAUSAL

    SBIR Phase I 1987 Department of Health and Human Services
  3. IMAGING OF ELEMENTS IN TISSUE AT TRACE CONCENTRATIONS

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    INSTRUMENTATION ENABLING QUANTITATIVE TRACE ELEMENT-CONCENTRATION IMAGING WITH HIGH SENSITIVITY AND RESOLUTION (1 PPM, 5 ) OF BIOLOGICAL TISSUE SECTIONS OVER 2X2MM(2) WOULD BE A VALUABLE RESEARCH TOOL. SIMULTANEOUS STRUCTURAL IMAGING WOULD ENHANCE ITS UTILITY. SPUTTER-INITIATED RESONANCE IONIZATION SPECTROSCOPY (SIRIS) WILL BE ADAPTED TO PROVIDE STRUCTURAL IMAGING AND QUANTITATIVE ELEMENT-CONCENTR ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. SUBPICOSECOND DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    EMERGING HEALTH AND MEDICAL RESEARCH PROBLEMS ARE PLACING STRINGENT REQUIREMENTS ON THE ABILITY TO CHARACTERIZE LABILEAND HIGH-MOLECULAR-WEIGHT ORGANIC COMPOUNDS. IN BIOTECHNOLOGY, FOR EXAMPLE, INTERMEDIATE SYNTHESIS PRODUCTS MUST BE IDENTIFIED. RECENT ION BOMBARDMENT DESORPTION MODELS SUGGEST THAT HIGHEST-MOLECULAR-WEIGHT COMPOUNDS WOULDDESORB MOST EFFICIENTLY THROUGH RAPID, MULTIPLE EXCITATIONS ...

    SBIR Phase I 1987 Department of Health and Human Services
  5. CHROMIUM DEFICIENCY IN INSULIN RESISTANCE

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  6. RAMAN SCATTERING FOR CLINICAL GAS DIAGNOSIS

    SBC: Biomaterials International Inc            Topic: N/A

    THIS PROJECT ADDRESSES THE DEVELOPMENT AND EVALUATION OF A PROTOTYPE LASER RAMAN SCATTERING GAS SENSOR. POTENTIAL APPLICATION AREAS ARE: BLOOD PO2/PCO2 VIA SUITABLE SAMPLING CATHETER AND NONINVASIVE MONITORING OF RESPIRATION, ANESTHESIA DELIVERY, LUNG FUNCTION, AND CARDIAC OUTPUT. MASS SPEC, WHILE CURRENTLY THE MOST POPULAR APPROACH TO MEDICAL GAS QUANTITATION, SUFFERS FROM INHERENT USER UNFRIENDL ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. MINIATURIZED RAMAN CLINICAL GAS ANALYZER

    SBC: Biomaterials International Inc            Topic: N/A

    A NEED EXISTS TO QUANTITATE ANESTHETIC AND RESPIRATORY GASES(O2, CO2, N2) IN THE OPERATING ROOM. PREVIOUS WORK HAS SHOWN THAT RAMAN LIGHT SCATTERING CAN BE SUCCESSFULLY UTILIZED FOR MOLECULAR GAS ANALYSIS. THE RAMAN SIGNAL FOR EACH GAS CAN BE SEPARATED FROM THE LASER BEAM RAYLEIGH SCATTER VIA FILTER COMBINATIONS, THUS ELIMINATING THE NEED FOR LARGE, EXPENSIVE MONOCHROMATORS. THIS PROPOSAL ADDRESSE ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. FIBEROPTIC PH SENSOR FOR IN VIVO MEASUREMENTS

    SBC: Biomaterials International Inc            Topic: N/A

    THE DEVELOPMENT OF A FIBEROPTIC PH PROBE IS PROPOSED USING A FLUORESCENT DYE IMMOBILIZED IN A HYDROPHILIC GEL MATRIX. THE MAIN TASKS IN THIS PROJECT ARE: (1) SET-UP OF RESEARCH INSTRUMENTATION FOR MEASURING AND CHARACTERIZING EXPERIMENTAL PROBES, (2) SELECTION AND IMMOBILIZATION OF DYES AT THE TIP OF THE OPTICAL FIBER, AND (3) TEST PH PROBESFOR SIGNAL INTENSITY, PH SENSITIVITY, TIME RESPONSE, PHOT ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. HEPARIN ADSORPTION COMPLEXES FOR BLOOD COMPATIBILITY

    SBC: Biomaterials International Inc            Topic: N/A

    THE ANTICOAGULANT, HEPARIN, WILL BE DERIVATIZED WITH BIOLOGICALLY COMPATIBLE HYDROPHOBIC MACROMOLECULES TO MAKE THEM WATER INSOLUBLE. THIS DERIVATIZATION WILL OCCUR THROUGH HYDROPHILIC SPACER GROUPS, ALLOWING THE HEPARIN TO EXTEND INTO THE AQUEOUS ENVIRONMENT AND RETAIN ITS BIOACTIVE CONFIGURATION. THESE HEPARIN DERIVATIVES WILL BE SOLVENT-COATED ONTO BIOMEDICAL DEVICES TO PROVIDE LOW-COST, IMMOBI ...

    SBIR Phase I 1987 Department of Health and Human Services
  10. POLYMERIC MATERIALS TO MINIMIZE CELL AND TISSUE ADHESION

    SBC: Biomaterials International Inc            Topic: N/A

    USING THE MOUSE PERITONEAL IMPLANT MODEL, MATERIALS WILL BE EVALUATED FOR THEIR BIOCOMPATIBILITY. THE OBJECTIVE OF THISSTUDY WILL BE TO DEVELOP MATERIALS WITH MINIMAL TENDENCY FORCELLULAR AND TISSUE ADHESION. POLYURETHANES AND SILICONES, MATERIALS WIDELY USED IN BIOMEDICAL DEVICE FABRICATION, WILLBE SYNTHESIZED OR MODIFIED TO YIELD A HIGH CONCENTRATION OF POLYETHER FUNCTIONALITY AT THE POLYMER SUR ...

    SBIR Phase I 1987 Department of Health and Human Services

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