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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. TOPIC #366- PHASE II SBIR CONTRACT- CLONOGENIC HIGH- THROUGHPUT ASSAY FOR SCREENING RADIATION MODULATION

    SBC: SuviCa, Inc.            Topic: NCI

    Clonogenic assays measure the ability of single cells to proliferate and form a colonyThis process approximates closely the regrowth and recurrence of tumors after treatment with radiation or chemotherapyproviding an assay to screen for drugs that block this processYetclonogenic assays are labor intensive and too cumbersome for high throughout screeningHTSof compound librariesHere we propose to de ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 389- INTELLIGENT SOFTWARE FOR RADIATION THERAPY PLANNING

    SBC: RadiaSoft LLC            Topic: NCI

    Besides surgeryradiotherapy is the most effective treatment modality for localized prostate cancerThe success of radiotherapy stems from the exploit of a therapeutic window in tumor response and normal tissue tolerance which maximizes the chance of sterilizing the tumor while sparing the surrounding normal tissue from severe damageThis requires an accurate and individualized radiation dose distrib ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Bioinformatic Tools for Interpretation of Glycan Array Data

    SBC: Z Biotech, LLC            Topic: 400

    Project SummaryAbstract There is an urgent need of bioinformatic tools for mining glycan array data in order to accurately and statistically study the interactions between cell surface glycans and glycan binding proteinsWe propose here to develop a software and hardware integrated system for the interpretation of glycan array dataThe problem with existing glycan array data mining tools is that the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Organic photoredox catalysts as sustainable and cost-effective replacement for precious metal complexes in light-driven drug synthesis

    SBC: New Iridium Inc            Topic: 300

    PROJECT SUMMARYLight driven chemistryor photoredox catalysishas made significant advances in the last decade for practical organic or drug synthesisFor examplelight induced reactions have enabled generation of radical intermediate Rfor direct functionalization of biologically relevant heterocycles and cross coupling reactions for important covalent bond formationsThereforephotoredox catalysis offe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Personal Mercury Monitor for Exposure Measurements

    SBC: First American Scientific Corporati            Topic: NIEHS

    Personal Mercury Monitor for Exposure Measurements Project Summary AbstractWorkers in the oil and natural gas industry are vulnerable to exposure to toxic mercuryHgvapor as a result of routine inspection and maintenance of equipment such as compressors and other process equipment that concentrate species of low volatility over timeExposure of workers to elemental mercury vapor is of concern in man ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: Oculo Therapy, LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the worldElevated intraocular pressureIOPis the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucomathe most common form of glaucomaThe current standard of care for glaucoma includes IOPlowering medications delivered topically as eye dropswhich decrease the vol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Targeted Intraceptors for Macular Degeneration

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: NEI

    Project Summary Age related Macular DegenerationAMDis the leading cause of blindness in USIt affects overof the people by the ageAn estimatedmillion people are afflicted with AMD worldwideNeovascular orwetAMDwhich affectsof AMD patientsis a rapid form of the disease and progresses to blindness if left untreatedHistopathologicallythe disease involves lesions in the Bruchandapos s membrane and or re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Point-of-Care Prognostic Tool for Sepsis

    SBC: Mbio Diagnostics, Inc.            Topic: 300

    Sepsis is a devastating cause of morbidity and mortality in intensive care unitsICUswith estimates of U Sincidence ranging fromtomillion cases annuallyThe heterogeneity of clinical presentationetiologypatient historyseverityetccreates a major challenge for patient management and has significantly complicated development of new therapiesalmost all of which have failed to show significant benefitBec ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Accessible And Robust Tools for Glycosaminoglycan Profiling

    SBC: ECHELON BIOSCIENCES, INC.            Topic: 300

    GlycosaminoglycansGAGsare polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrixMore recentlychanges in the contentsizeand composition of GAGs have been found to play biological roles in disease processes as wellFor examplechondroitin sulfateCSis the most abundant GAGhoweveronly th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Developing a Small Peptide to Control Autoimmune Inflammation In Type 1 Diabetes

    SBC: Op-T-Mune, Inc            Topic: NIAID

    TypeDiabetesT Daffects an ever growing populationWhile this disease typically has been associated with juvenilesthe disease in adult populations is rapidly increasingThe defining clinical component is insulin losswhich occurs because of sustained inflammation in the isletsAt present there is no means to prevent or reverse insulin lossA major inflammatory pathway in T D that contributes to insulin ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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