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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. BIOCHEMICAL MONITORING OF PESTICIDES, SOLVENTS, AND THEIR ME

    SBC: Lee Scientific Inc            Topic: N/A

    THE DETECTION AND CHARACTERIZATION OF PESTICIDES, INDUSTRIAL SOLVENTS, AND THEIR METABOLITES IN BODY FLUIDS AND TISSUES ARE IMPORTANT FOR EVALUATING THE POTENTIAL LONG-TERM HEALTH EFFECTS OF THE EXPOSED POPULATION. UNFORTUNATELY, ANALYTICAL METHODS PRESENTLY AVAILABLE ARE GENERALLY TEDIOUS, TIME-CONSUMING, COMPLEX OR NONSPECIFIC AND LACK REQUIRED SENSITIVITY. THIS STUDY WILL EVALUATE CAPILLARY SUP ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. TOPICAL PRODRUGS FOR TREATMENT OF ACNE AND SKIN DISEASES

    SBC: MOLECULAR DESIGN INTERNATIONAL, INC.            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COMMERCIAL PRODUCT FOR THE TOPICAL TREATMENT OF ACNE AND SKIN DISEASES. THE SPECIFIC AIM OF THE PROPOSAL IS TO INVENT A PRODRUG THAT CAN BE USED EFFECTIVELY AND SAFELY FOR THE TOPICAL TREATMENT OF ACNE. SINCE ISOTRETINOIN (13-CIS-RETINOIC ACID, ACCUTANE-ROCHE) ADMINISTERED ORALLY CAUSES BIRTH DEFECTS AND APPLIED TOPICALLY IS IRRITATING, WE HA ...

    SBIR Phase II 1987 Department of Health and Human Services
  3. NEONATAL NUTRITION AND RESONANCE IONIZATION SPECTROSCOPY

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    A PAUCITY OF KNOWLEDGE EXISTS ABOUT NEONATAL TRACE ELEMENT NUTRITION REQUIREMENTS, ESPECIALLY FOR PREMATURE INFANTS, WHOSE CRITICAL FINAL TRIMESTER ACCUMULATION OF ESSENTIAL TRACE ELEMENTS IS ABRUPTLY CEASED AT BIRTH. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE SCIENCE AND TECHNOLOGY "BRIDGE" REQUIRED TO DEMONSTRATE THE FEASIBILITY OF DIRECT, OR NEARLY DIRECT, DETERMINATION BY RESONANCE IONIZ ...

    SBIR Phase II 1987 Department of Health and Human Services
  4. AN EXTRAPULMONARY BLOOD GAS EXCHANGE DEVICE

    SBC: Midmid Inc            Topic: N/A

    A MULTICHANNEL TUBULAR DEVICE CONTAINING ULTRA-THIN WALLED TUBES, PERMEABLE TO O2 AND CO2, WILL BE DESIGNED AND FABRICATED FOR USE AS AN EXTRAPULMONARY BLOOD GAS EXCHANGE DEVICE. THE PRODUCT IS INTENDED TO BE INSERTED INTO THE SUBJECT'S VENA CAVAL SYSTEM, ENTERING INTO THE RIGHT COMMON FEMORAL VEIN AND EXITING FROM THE RIGHT EXTERNAL JUGULAR VEIN. OXYGEN IS PASSED THROUGH THE LUMINA OF THE HOLLOW ...

    SBIR Phase II 1987 Department of Health and Human Services
  5. RAMAN SCATTERING FOR CLINICAL GAS DIAGNOSIS

    SBC: Biomaterials International Inc            Topic: N/A

    THIS PROJECT ADDRESSES THE DEVELOPMENT AND EVALUATION OF A PROTOTYPE LASER RAMAN SCATTERING GAS SENSOR. POTENTIAL APPLICATION AREAS ARE: BLOOD PO2/PCO2 VIA SUITABLE SAMPLING CATHETER AND NONINVASIVE MONITORING OF RESPIRATION, ANESTHESIA DELIVERY, LUNG FUNCTION, AND CARDIAC OUTPUT. MASS SPEC, WHILE CURRENTLY THE MOST POPULAR APPROACH TO MEDICAL GAS QUANTITATION, SUFFERS FROM INHERENT USER UNFRIENDL ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. SUPERCRITICAL FLUID CHROMATOGRAPHY OF CANNABINOIDS

    SBC: Lee Scientific Inc            Topic: N/A

    THE ANALYSIS OF CANNABINOIDS FOR RESEARCH OR SCREENING FOR CANNABIS ABUSE REQUIRES METHODS CAPABLE OF CHARACTERIZING AND QUANTIFYING METABOLITES OF THE CANNABINOIDS WHICH ARE GENERALLY POLAR OR THERMALLY UNSTABLE AND WHICH MUST BE SEPARATED FROM A COMPLEX BIOLOGICAL MATRIX. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS PROPOSED AS A METHOD WHICH IS CAPABLE OF PROVIDING HIGH-RESOLUTION SEPARATION OF ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. TRACE CHROMIUM IN DIABETES USING RESONANCE IONIZATION

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    TRACE ELEMENT NUTRITURE IS INCREASINGLY ACKNOWLEDGED AS A KEY ASPECT OF GROWTH, DEVELOPMENT, AND HEALTH. TRACE CHROMIUM MAY BE RELATED TO REGULATION OF INSULATION ACTION, RESTORATION OF IMPAIRED GLUCOSE TOLERANCE, AND THE CAUSAL

    SBIR Phase I 1987 Department of Health and Human Services
  8. IMAGING OF ELEMENTS IN TISSUE AT TRACE CONCENTRATIONS

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    INSTRUMENTATION ENABLING QUANTITATIVE TRACE ELEMENT-CONCENTRATION IMAGING WITH HIGH SENSITIVITY AND RESOLUTION (1 PPM, 5 ) OF BIOLOGICAL TISSUE SECTIONS OVER 2X2MM(2) WOULD BE A VALUABLE RESEARCH TOOL. SIMULTANEOUS STRUCTURAL IMAGING WOULD ENHANCE ITS UTILITY. SPUTTER-INITIATED RESONANCE IONIZATION SPECTROSCOPY (SIRIS) WILL BE ADAPTED TO PROVIDE STRUCTURAL IMAGING AND QUANTITATIVE ELEMENT-CONCENTR ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. SUBPICOSECOND DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    EMERGING HEALTH AND MEDICAL RESEARCH PROBLEMS ARE PLACING STRINGENT REQUIREMENTS ON THE ABILITY TO CHARACTERIZE LABILEAND HIGH-MOLECULAR-WEIGHT ORGANIC COMPOUNDS. IN BIOTECHNOLOGY, FOR EXAMPLE, INTERMEDIATE SYNTHESIS PRODUCTS MUST BE IDENTIFIED. RECENT ION BOMBARDMENT DESORPTION MODELS SUGGEST THAT HIGHEST-MOLECULAR-WEIGHT COMPOUNDS WOULDDESORB MOST EFFICIENTLY THROUGH RAPID, MULTIPLE EXCITATIONS ...

    SBIR Phase I 1987 Department of Health and Human Services
  10. URINARY TRACT INFECTIONS ASSOCIATED WITH URINARY DRAINAGE CATHETERS ARE A SIGNIFICANT CLINICAL PROBLEM RESULTING IN A PROLONGED HOSPITAL STAY AND AN INCREASED MORTALITY RISK.

    SBC: Biomaterials International Inc            Topic: N/A

    URINARY TRACT INFECTIONS ASSOCIATED WITH URINARY DRAINAGE CATHETERS ARE A SIGNIFICANT CLINICAL PROBLEM RESULTING IN A PROLONGED HOSPITAL STAY AND AN INCREASED MORTALITY RISK. THIS PROPOSAL ADDRESSES A FEASIBILITY STUDY TO DETERMINE IF SURFACE MODIFICATION OF THE CATHETER WILL INHIBIT BACTERIAL MIGRATION. THE PROPOSED RESEARCH WILL TEST THE HYPOTHESIS THAT BACTERIAL FIVE DIFFERENT SURFACE TREATMENT ...

    SBIR Phase I 1985 Department of Health and Human Services

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