Award Data

The team will develop a prototype of Collaborate, a traditional board game for use in high school and college level computer science courses. Gameplay mechanics will center on strategy and cooperation with a whole class over several weeks. Content will focus on foundational computer science topics, such user interface design, quality assurance, deploying resources, managing risk, and adjusting to ...

Technology validation study of a wearable NIR spectrometer to quantify BAC in real time

Developing safe and effective preventives for HIV remains the hope for controlling the global AIDS epidemicRecentlymRNA vaccines have emerged as a promising alternative to conventional vaccine approaches because of their high potencycapacity for rapid developmentpotential for low cost manufactureTo datethere is no effective mRNA protective vaccine for HIVand the need for one is vastDespite the adv ...

Specific AimsIn Phase I of this SBIRwe will complete three specific aimssynthesize stable combination adjuvant formulations that are compatible with an HVLP antigenidentify the combination adjuvant properties that augment the safe and durable immunity to Handdemonstrate the superior protective benefit of the new combination adjuvant over existing adjuvant solutions for pandemic influenza vaccinesI ...

In this projectParabon NanoLabs and The Scripps Research Institute propose to develop and produce an effective HIVvaccine using a structured DNA origami nanocarrier for the targetedcontrolled delivery of a stabilizedtrimeric HIVenvelope glycoproteinEnvwith an integrated adjuvantThe project will begin with the synthesis and characterization of composite nanostructurePV NFLto include development and ...

Congenital cytomegalovirusCMVinfection is the leading cause of permanent disabilitiescognitive impairmentand sensorineural hearing loss to newbornsMaternal infections that occur during pregnancy and symptomatic congenital CMV infections have been correlated with the most severe complicationsClinical trials are currently evaluating safety and immunogenicity of diverse vaccine candidates driven by t ...

InoverAmericans died as a result of opioid overdosemaking opioid use the leading cause of death for Americans underThis crisis affects both males and femalesthus leading to a surge in the number of babies born with opioid addictionthe withdrawal from which is termed Neonatal Abstinence SyndromeNASIninstances of newborn opioid dependence were recordedDiagnostic metrics seek to standardize diagnosis ...

The goal of this project is to solicit the innovative development of diagnostic testing platforms that can simultaneously detect antigens of multiple pathogens and different antibody isotypes and or immune factors against those pathogens in a single multiplex assayThe pathogens of interest includebut are not limited tothose with a high potential for causing global disease outbreaks that affect vul ...

In vivo imaging of cells labeled with fluorescent nanodiamondsFNDsis a new way of monitoring immune cells during cancer immunotherapyFNDs are non toxicinfinitely photostable nanomaterials that are easily conjugated with antibodiesand emit fluorescence in the near infrared spectral regionIn this Phase I SBIRwe will use a murine melanoma model and outline a plan to use FNDs for imaging immunosupress ...

PROJECT SUMMARY ABSTRACT While patient self report of pain is currently the gold standard of pain measurementaccurate self reports of pain may not be feasible in critically ill patients who are sedated and intubatedunconscious patientsor patients who are unable to verbally communicate their painCurrent research has shown that pupillary dilationPDis a reliable indicator of acute painand that measur ...