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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Measuring Activities of Daily Living in Stroke Patients with Motion Artificial Intelligence

    SBC: NEWVENTUREIQ LLC            Topic: Na

    The goal this project is to create a motion artificial intelligence (AI) analysis software to monitor activities of daily living (ADL) for stroke survivors with disabilities. The project utilizes wearable smart devices and a supervised machine learning (ML) algorithm to monitor activities that are meaningful and useful for clinicians and healthcare providers. Objectives are: (1) create a working M ...

    SBIR Phase I 2019 Department of Health and Human ServicesAdministration for Community Living
  2. A Self-Replicating RNA Vaccine Against HIV-1 Delivered Using A Nanoparticle Adjuvant

    SBC: PAI LIFE SCIENCES INC            Topic: NIAID

    An effective vaccine against HIV offers the best chance to stop the global epidemic but remains elusive to dateResearch has primarily focused on subunit monomerice ggpor gpor trimeric antigensthe former approachoften adjuvanted with alumhas failed in clinical trialsNative like trimers mimic the Env spike but are still poorly immunogenic and require elaborate adjuvant screening efforts to potentiat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Prophylactic Onchocerciasis Vaccine

    SBC: PAI LIFE SCIENCES INC            Topic: NIAID

    Humanriver blindnessis caused by a filarial parasite and is a serious neglected tropical disease contributing to blindnessskin diseaseand chronic disability in the developing worldEstimates from the Global Burden of Disease Studyindicate thatmillion cases of onchocerciasisleading tomillion cases of vision impairmentoccur worldwide every yearThe goal of this project is to develop a safe and effecti ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Rational Development of a Combination Nanoparticle Adjuvant for Influenza

    SBC: HDT BIO CORP            Topic: NIAID

    SignificanceHighly pathogenic avian H Ninfluenzawhich has killedpeople sinceis poised to cause a pandemic in a worldwide population that has no pre existing immunityCurrent Hvaccines are insufficiently immunogenic without the addition of adjuvantsbut responses to these adjuvanted vaccines are not durable and may not be protective against newly emergent viral strainsProposed solutionWe have develop ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Person-Centered Planning ToolKit: Development of an Application to Improve Workforce Participation for Individuals with Cognitive Disabilities Through Team Collaboration and Employment Discovery

    SBC: ASSISTECH SYSTEMS LLC            Topic: na

    This project evaluates the usability and feasibility of a Person-Centered Planning Toolkit to address the need for increased opportunities for competitive integrated employment for individuals with cognitive disabilities. The Toolkit enhances implementation of person-centered planning (PCP), often limited by lack of follow-through on action items, and a lack of tools to match career preferences to ...

    SBIR Phase II 2019 Department of Health and Human ServicesAdministration for Community Living
  6. A Phase 1 Randomized Single Oral Dose Four Period Cross-Over Study Investigating Omnitram Dose Proportionality and Food Effect in Normal Human Subjects

    SBC: Syntrix Biosystems, Inc.            Topic: NIDA

    Fromthe utilization of the Schedule II opioids codeineOxyContin and fentanyl declined significantlydown aboutfor all three drugsIn sharp contrastthe use of tramadola Schedule IV controlled substanceincreasedSchedule IV substances have low potential for abuse and harm relative to Schedule II substancesand the fortuitous trend to tramadol has reduced the use of the relatively unsafe Schedule II opio ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Immuno Oncology Product for Multiple Myeloma: g-NK Cellular Therapy to Optimize Monoclonal Antibody Efficacy in Treating Multiple

    SBC: Indapta Therapeutic            Topic: 102

    Project Summary Abstract Multiple myeloma is the second most common hematologic malignancy in the USwith aboutnew cases in the US each yearMost patients with MM relapse and eventually become unresponsive to treatmentAlthough multiple new therapies for MM have come on the markettheir promise is limited by concerns about toxicity and low efficacyand MM remains incurableThereforethere is an urgentdem ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: OCULO THERAPY LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) is the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucoma, the most common form of glaucoma. The current standard of care for glaucoma includes IOP- lowering medications delivered topically as eye drops, which de ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Translational development of specialized NK cells for cancer immunotherapy

    SBC: Indapta Therapeutic            Topic: 102

    Project Summary Abstract The annual incidence of head and neck cancers worldwide is more thancases with arounddeaths each yearand it is estimated that inthere will benew cases of non Hodgkin lymphoma with an estimateddeaths this yearIn this proposalwe describe a strategy to use a novel subset of natural killer cellsg NK cellsallogeneically for cancer therapyWe hypothesize that expansion and adopti ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Object Oriented Data Analysis for Untargeted Metabolomics

    SBC: WILLIAM D SHANNON CONSULTING LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT In this Phase I SBIR applicationwe propose to develop and optimize functional Object Oriented Data AnalysisfOODAmethods and create a cloud based SaaS platform to analyze untargeted metabolomics dataUntargeted metabolomics quantifies the amount of known and unknown metabolites in samples with the purpose of finding known and unknown metabolites that correlate with subgroups ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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