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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Graphene-based Nanosensor Device for Rapid, Onsite Detection of Total Lead in Tap Water

    SBC: NANOAFFIX SCIENCE LLC            Topic: NIEHS

    PROJECT SUMMARY Detrimental health impacts of lead are largely attributed to long-term exposures to undetected lead, which are particularly troublesome and problematic because of the neurological damage to children, a situation that should not be tolerated by an advanced society like the U.S. The Flint Water Crisis and many other water catastrophes could have been avoided if early warning can be m ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Preventing Neurovascular Matrix Degradation and Hemorrhage in Acute Ischemic Stroke

    SBC: TRANSLATIONAL SCIENCES INC            Topic: NHLBI

    Seventeen million people each year suffer from an ischemic stroke and millions are left dead and disabledTreatment with recombinant tissue plasminogen activatorr tPAis only modestly effective at reducing disability and it is associated with brain hemorrhage in up toof patients when serial imaging studies are performedBrain hemorrhage causes death and disability andis the major cause of early morta ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a dual MDM2/XIAP inhibitor with a high therapeutic index for childhood cancers

    SBC: SEAK Therapeutics, LLC            Topic: NCI

    PROJECT SUMMARYAcute lymphoblastic leukemia (ALL) and neuroblastoma (NB) are the most common cancers in children. Currently treatment options are often associated with severe side effects. Therefore, there is a strong unmet medical need to develop targeted-drugs with higher therapeutic indexes for improved treatment outcome.The oncoproteins MDM2 and XIAP are important cell-survival proteins in tum ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Accelerating Functional Maturation of Human Neurons for High-Throughput Screening

    SBC: BrainXell, Inc            Topic: 44

    Project Summary/AbstractNeurological and psychiatric disorders, including drug abuse and addiction, exert a devastating personal and economic toll on patients, families, caregivers, and society. This is in part due to our failure in developing effective medications, which in turn is due to the use of drug discovery platforms that are often not relevant to target diseases. The recent development of ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Ultrathin Dissolvable Antibiofilm Wound Contact Dressing with Silver and Gallium

    SBC: IMBED BIOSCIENCES INC            Topic: NIAMS

    The entire Research Plan contains proprietary/privileged information that Imbed Biosciences requests not be released to persons outside the Government, except for purposes of review and evaluation. SUMMARY The health care costs associated with treatment of chronic wounds exceeds $25 billion annually in the U.S. Biofilms are implicated as a key factor responsible for delayed healing. Many wounds ha ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Autoscreen: An innovative e-health solution for early identification of Autism Spectrum Disorder Phase II

    SBC: Adaptive Technology Consulting, LLC            Topic: 103

    PROJECT SUMMARY Early accurate identification and treatment of young children with Autism Spectrum Disorder (ASD) represents a pressing public health and clinical care challenge. Given mounting evidence that early, accurate diagnosis of ASD is possible and that very young children who receive intervention can demonstrate substantial gains in functioning, current American Academy of Pediatrics prac ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of the High Throughput APT-SNAP Platform for Rapid Identification ofNuclease-Resistant RNA Aptamers against p53 Missense Mutations

    SBC: Proteovista LLC            Topic: 102

    Project Summary Development of the High Throughput APT SNAP Platform for Rapid Identificationof Nuclease Resistant RNA Aptamers against pMissense MutationsPIsChristopher LWarren and Mary SOzers Normal proteins are often mutated in cancergenerating dominant negative effects as well as gain of function activity that contribute to cancer development and to the inhibition of therapeutic responsesProte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. SBIR Phase I: Evaluating the feasibility of the TotalTHM-NOW for drinking water treatment plants to improve water quality, reduce costs, and lower cancer risks

    SBC: Foundation Instruments, Inc.            Topic: NIEHS

    PROJECT SUMMARY ABSTRACT Research has suggested that there is an increased risk of cancer associated with long term exposure to drinking water containing halogenated disinfection by productsDBPsTrihalomethanesTHMsare the most common class of halogenated DBPs formed during water chlorinationEvery yearthousands of drinking water treatment plantsWTPsstruggle with THMs compliance issues often allocati ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Fully Human Antibodies for the Prevention of Respiratory Syncytial Virus

    SBC: IDBIOLOGICS INC            Topic: NIAID

    The goal of this STTR is to provide a preclinically validated monoclonal antibody or antibody combination for the prevention of respiratory syncytial virusRSVin high risk patients including infants and the elderlyWorldwideof children are infected with RSV before the age ofresulting in an estimatedmillion lower respiratory tract infectionsIn the United States adults overhavemillion RSV infections c ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid Production of Regional and Disease Specific Human Astrocytes for CNS Drug Discovery

    SBC: BrainXell, Inc            Topic: 105

    Project Summary AbstractThe personalsocietaland economic burden that disorders of the central nervous systemCNSplace on the United States is tremendousFromthe FDA approved justnew drugs to treat CNS disorders covering the clinical areas of neurologypsychiatryand painThat averages to just three new chemical entitiesNEIsper yearwhile clinical trial failure rates for CNS drug development remain great ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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