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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SENSITIVE PERSONNEL DOSIMETRY OF 3KEV TO 20MEV NEUTRONS

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    A FAST NEUTRON DOSIMETER IS PLANNED THAT WOULD BE USED BY PERSONNEL INVOLVED IN RESEARCH OR MEDICAL TREATMENT WITH NEUTRONS, AND WOULD THUS SATISFY SOME OF THE NEEDS OF THE NATIONAL CANCER INSTITUTE (NCI). THE DOSIMETER WILL BE SENSITIVE TO NEUTRONS OF >3-KEV ENERGY WITH NEGLIGIBLE RESPONSE TO OTHER RADIATION. THE NOVEL SYSTEM USES RESONANCE IONIZATION SPECTROSCOPY (RIS) TO COUNT NOBLE GAS ATOMS S ...

    SBIR Phase I 1989 Department of Health and Human Services
  2. A TIMING SYSTEM FOR POSITRON EMISSION TOMOGRAPHY

    SBC: CTI SERVICES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1989 Department of Health and Human Services
  3. MONOCLONAL ANTIBODIES FOR DIRECT STEROID IMMUNOASSAY

    SBC: Immunostics Inc            Topic: N/A

    THE GOAL FOR PHASE I IS TO OBTAIN A HIGHLY SPECIFIC MONOCLONAL ANTIBODY (MAB) FOR TESTOSTERONE WITH WHICH AN IMMUNOMETRIC ASSAY FOR TESTOSTERONE WILL BE DEVELOPED THAT HAS SUPERIOR ANALYTICAL ACCURACY THAN COMMERCIAL KITS CURRENTLY AVAILABLE. THE KEY ASPECT IS TO OBTAIN A MAB WITH THE NECESSARY SPECIFICITY AND AFFINITY. IMMUNOASSAYS CURRENTLY AVAILABLE SUFFER FROM OVERESTIMATION OF THE STEROID CON ...

    SBIR Phase I 1989 Department of Health and Human Services
  4. IMMUNODIAGNOSTIC ASSAY FOR INVASIVE CANDIDIASIS

    SBC: Jcl Clinical Research Corp            Topic: N/A

    INVASIVE AND DISSEMINATED INFECTION WITH THE FUNGAL OPPORTUNIST, CANDIDA ALBICANS, IS A FREQUENT, SERIOUS COMPLICATION ASSOCIATED WITH COMPROMISED IMMUNITY ARISING FROM DISEASE AND/OR THERAPEUTIC REGIMENS. TREATMENT FOR INVASIVE CANDIDIASIS IS AVAILABLE BUT IS DEPENDENT ON TIMELY DIAGNOSIS. THIS PROJECT WILL DEVELOP A SENSITIVE, DOUBLE-ANTIBODY ANTIGEN-CAPTURE ENZYME IMMUNOASSAY (EIA) THAT WILL DE ...

    SBIR Phase I 1989 Department of Health and Human Services
  5. NEONATAL NUTRITION AND RESONANCE IONIZATION SPECTROSCOPY

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    A PAUCITY OF KNOWLEDGE EXISTS ABOUT NEONATAL TRACE ELEMENT NUTRITION REQUIREMENTS, ESPECIALLY FOR PREMATURE INFANTS, WHOSE CRITICAL FINAL TRIMESTER ACCUMULATION OF ESSENTIAL TRACE ELEMENTS IS ABRUPTLY CEASED AT BIRTH. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE SCIENCE AND TECHNOLOGY "BRIDGE" REQUIRED TO DEMONSTRATE THE FEASIBILITY OF DIRECT, OR NEARLY DIRECT, DETERMINATION BY RESONANCE IONIZ ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. TRACE CHROMIUM IN DIABETES USING RESONANCE IONIZATION

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    TRACE ELEMENT NUTRITURE IS INCREASINGLY ACKNOWLEDGED AS A KEY ASPECT OF GROWTH, DEVELOPMENT, AND HEALTH. TRACE CHROMIUM MAY BE RELATED TO REGULATION OF INSULATION ACTION, RESTORATION OF IMPAIRED GLUCOSE TOLERANCE, AND THE CAUSAL

    SBIR Phase I 1987 Department of Health and Human Services
  7. IMAGING OF ELEMENTS IN TISSUE AT TRACE CONCENTRATIONS

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    INSTRUMENTATION ENABLING QUANTITATIVE TRACE ELEMENT-CONCENTRATION IMAGING WITH HIGH SENSITIVITY AND RESOLUTION (1 PPM, 5 ) OF BIOLOGICAL TISSUE SECTIONS OVER 2X2MM(2) WOULD BE A VALUABLE RESEARCH TOOL. SIMULTANEOUS STRUCTURAL IMAGING WOULD ENHANCE ITS UTILITY. SPUTTER-INITIATED RESONANCE IONIZATION SPECTROSCOPY (SIRIS) WILL BE ADAPTED TO PROVIDE STRUCTURAL IMAGING AND QUANTITATIVE ELEMENT-CONCENTR ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. SUBPICOSECOND DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    EMERGING HEALTH AND MEDICAL RESEARCH PROBLEMS ARE PLACING STRINGENT REQUIREMENTS ON THE ABILITY TO CHARACTERIZE LABILEAND HIGH-MOLECULAR-WEIGHT ORGANIC COMPOUNDS. IN BIOTECHNOLOGY, FOR EXAMPLE, INTERMEDIATE SYNTHESIS PRODUCTS MUST BE IDENTIFIED. RECENT ION BOMBARDMENT DESORPTION MODELS SUGGEST THAT HIGHEST-MOLECULAR-WEIGHT COMPOUNDS WOULDDESORB MOST EFFICIENTLY THROUGH RAPID, MULTIPLE EXCITATIONS ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. CHROMIUM DEFICIENCY IN INSULIN RESISTANCE

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  10. SEX SELECTION IN EMBRYO TRANSFER

    SBC: Center For Reproductive Bio            Topic: N/A

    IT IS PROPOSED TO DEVISE SEROLOGICAL METHODS FOR ROUTINE IDENTIFICATION OF MALE AND FEMALE BOVINE EMBRYOS, WITH A VIEW TO THE CONTROL OF SEX RATIO DURING COMMERCIAL EMBYRO TRANSFER. EMBRYOS WILL BE EXPOSED TO NEWLY DEVELOPED MONOCLONAL ANTIBODIES DIRECTED AGAINST MALE-SPECIFIC H-Y ANTIGEN AND THEN TO GOAT ANTIMOUSE-IG BEARING THE FLUORESCENT DYE, FITC. THE EMBRYOS WILL BE SCORED FOR LABELING UNDER ...

    SBIR Phase I 1987 Department of Health and Human Services

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