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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Molded Hydrogel Tympanic Membrane Repair Constructs

    SBC: GRACE MEDICAL, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Tympanic membrane perforations are commonly seen in otology practices and about 150,000 repair surgeries are performed each year in the United States. Current office-based procedures such as paper patch tympanoplasty are relatively ineffective or, like the irritant oil method, require multiple office visits. Surgical procedures including fascia and cartilag ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds

    SBC: ADVANCED PLASMA PRODUCTS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease and edema, and pressure ulcers, and traumatic injuries, including burns. There is a real need for new advanced technologies to treat chronic wounds since a significant number of these wounds do not heal aft ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Germanium Gamma Cameras

    SBC: PHDS COMPANY            Topic: NCRR

    DESCRIPTION (provided by applicant): Germanium gamma-ray imaging detectors will improve the quality of in-vivo molecular-imaging applications. The objective of this program is the development of the Germanium Gamma Cameras (GGCs) as modular component detector heads suitable for convenient integration into the molecular-imaging systems of other companies and research groups for small field-of-view ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Novel Topical Therapy for Diabetic Retinopathy using Beta-Adrenergic Receptor Ago

    SBC: MOLECULAR DESIGN INTERNATIONAL, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): The overall goal of our work is to establish the potency and efficacy of a novel 2-adrenergic receptor agonist (compound 49b) in the prevention and/or reversal of non-proliferative diabetic retinopathy. Diabetic retinopathy is the leading cause of blindness in working age adults. The current treatment paradigm for retinopathy patients has not changed signif ...

    STTR Phase I 2011 Department of Health and Human Services
  5. Wheelchair Drive System

    SBC: MAX MOBILITY            Topic: NICHD

    DESCRIPTION (provided by applicant): Wheelchair Drive System Over half of the wheelchair user population has developed upper extremity (UE) pain and injury. One of the activities that likely contribute to the development of injury is wheelchair propulsion. A number of technologies have been developed to address this issue including ergonomic pushrims, geared hub wheels, lever drives and pushrim-a ...

    SBIR Phase II 2011 Department of Health and Human Services
  6. TAS::75 0849::TAS

    SBC: RxBio, Inc.            Topic: NCI

    No satisfactory medical interventions for radiation enteritis are available yet. We have demonstrated that polyamine inhibition by a-difluoromethylornithine orDFMO, a selective and irreversible inhibitor of ornithine decarboxylase (ODC, the primary rate-limiting enzyme in the production of polyamines) significantly protects the gastrointestinal (GI) tract from whole-body radiation exposure. Here w ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. TAS::75 0849::TAS SBIR TOPIC 277- DEVELOPMENT OF A CLINICAL DIAGNOSTIC ASSAY FOR ALK INHIBITOR RESISTANCE MUTATIONS

    SBC: Environmental Metrology Corporation            Topic: NCI

    Kinase inhibitors have revolutionized cancer treatment but their use has led to drug resistance, prompting development of follow-on inhibitors for resistant tumors. Anaplastic lymphoma kinase (ALK) was discovered by Dr. Stephan Morris (Insight Genetics collaborator on these studies). ALK fusion genes and activating point mutations cause several cancers, and multiple pharmaceutical firms are devel ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Trimer-Tag: A Technology for Producing Trivalent Biologics

    SBC: GENHUNTER CORPORATION            Topic: NIAID

    DESCRIPTION (provided by applicant): One of the modern strategies for treating autoimmune diseases such as rheumatoid arthritis and psoriasis involves the use of biologic TNF receptor decoys, such as soluble receptors or therapeutic antibodies, to intercept the inflammatory ligand TNF-1, and thus block the pathological activation of its receptors. However, current TNF-1 biologic blockers are all d ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. High Throughput, Label-Fee Molecular Interaction Platform for Membrane Protein

    SBC: MOLECULAR SENSING, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Molecular interactions form the basis of healthy metabolism as well as the manifestation of disease, and comprise the very foundation of drug treatment. Tools available to study molecular interactions in their nascent environment and physiological concentrations without chemical modification, such as surface immobilization or labeling, are limited. Current labe ...

    SBIR Phase II 2011 Department of Health and Human Services
  10. TAS::75 0894::TAS SBIR PHASE II- IDENTIFICATION OF ALCOHOL-RELEVANT MIRNA BIOMARKERS

    SBC: GENOME EXPLORATION, INC.            Topic: NICHD

    Alcohol abuse and its related health effects are estimated to have an economic cost in the US that approaches $200 Billion per year. However, current tests for alcohol use/abuse are not reliable except when administered within several hours of intoxication. Moreover, current clinical tests for alcohol-related organ damage only provide reasonable diagnostic and prognostic value after the damage has ...

    SBIR Phase II 2011 Department of Health and Human Services

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