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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. NEONATAL NUTRITION AND RESONANCE IONIZATION SPECTROSCOPY

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    A PAUCITY OF KNOWLEDGE EXISTS ABOUT NEONATAL TRACE ELEMENT NUTRITION REQUIREMENTS, ESPECIALLY FOR PREMATURE INFANTS, WHOSE CRITICAL FINAL TRIMESTER ACCUMULATION OF ESSENTIAL TRACE ELEMENTS IS ABRUPTLY CEASED AT BIRTH. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE SCIENCE AND TECHNOLOGY "BRIDGE" REQUIRED TO DEMONSTRATE THE FEASIBILITY OF DIRECT, OR NEARLY DIRECT, DETERMINATION BY RESONANCE IONIZ ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. TRACE CHROMIUM IN DIABETES USING RESONANCE IONIZATION

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    TRACE ELEMENT NUTRITURE IS INCREASINGLY ACKNOWLEDGED AS A KEY ASPECT OF GROWTH, DEVELOPMENT, AND HEALTH. TRACE CHROMIUM MAY BE RELATED TO REGULATION OF INSULATION ACTION, RESTORATION OF IMPAIRED GLUCOSE TOLERANCE, AND THE CAUSAL

    SBIR Phase I 1987 Department of Health and Human Services
  3. IMAGING OF ELEMENTS IN TISSUE AT TRACE CONCENTRATIONS

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    INSTRUMENTATION ENABLING QUANTITATIVE TRACE ELEMENT-CONCENTRATION IMAGING WITH HIGH SENSITIVITY AND RESOLUTION (1 PPM, 5 ) OF BIOLOGICAL TISSUE SECTIONS OVER 2X2MM(2) WOULD BE A VALUABLE RESEARCH TOOL. SIMULTANEOUS STRUCTURAL IMAGING WOULD ENHANCE ITS UTILITY. SPUTTER-INITIATED RESONANCE IONIZATION SPECTROSCOPY (SIRIS) WILL BE ADAPTED TO PROVIDE STRUCTURAL IMAGING AND QUANTITATIVE ELEMENT-CONCENTR ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. SUBPICOSECOND DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    EMERGING HEALTH AND MEDICAL RESEARCH PROBLEMS ARE PLACING STRINGENT REQUIREMENTS ON THE ABILITY TO CHARACTERIZE LABILEAND HIGH-MOLECULAR-WEIGHT ORGANIC COMPOUNDS. IN BIOTECHNOLOGY, FOR EXAMPLE, INTERMEDIATE SYNTHESIS PRODUCTS MUST BE IDENTIFIED. RECENT ION BOMBARDMENT DESORPTION MODELS SUGGEST THAT HIGHEST-MOLECULAR-WEIGHT COMPOUNDS WOULDDESORB MOST EFFICIENTLY THROUGH RAPID, MULTIPLE EXCITATIONS ...

    SBIR Phase I 1987 Department of Health and Human Services
  5. CHROMIUM DEFICIENCY IN INSULIN RESISTANCE

    SBC: ATOM SCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  6. SEX SELECTION IN EMBRYO TRANSFER

    SBC: Center For Reproductive Bio            Topic: N/A

    IT IS PROPOSED TO DEVISE SEROLOGICAL METHODS FOR ROUTINE IDENTIFICATION OF MALE AND FEMALE BOVINE EMBRYOS, WITH A VIEW TO THE CONTROL OF SEX RATIO DURING COMMERCIAL EMBYRO TRANSFER. EMBRYOS WILL BE EXPOSED TO NEWLY DEVELOPED MONOCLONAL ANTIBODIES DIRECTED AGAINST MALE-SPECIFIC H-Y ANTIGEN AND THEN TO GOAT ANTIMOUSE-IG BEARING THE FLUORESCENT DYE, FITC. THE EMBRYOS WILL BE SCORED FOR LABELING UNDER ...

    SBIR Phase I 1987 Department of Health and Human Services
  7. A TWO-DIMENSIONAL PHOTON-COUNTING POSITION ENCODER IS PROPOSED FOR POSITION EMISSION TOMOGRAPHY (PET) 1.

    SBC: CTI SERVICES, INC.            Topic: N/A

    A TWO-DIMENSIONAL PHOTON-COUNTING POSITION ENCODER IS PROPOSED FOR POSITION EMISSION TOMOGRAPHY (PET) 1. A METHOD OF CONTROLLING THE SPATIAL DISTRIBUTION OF PHOTONS FROM BISMUTH GERMANATE SCINTILLATORS, 2. THE USE OF ALL-DIGITAL PHOTON COUNTING FOR PROCESSING THE PHOTOMULTIPLIER SIGNAL, AND 3. THE USE OF PATTERN RECOGNITION TO ENCODE POSITION. THE NEW DETECTOR IS EXPECTED TO REDUCE THE COST OF THI ...

    SBIR Phase I 1985 Department of Health and Human Services
  8. THE DEVELOPMENT OF AN AUTOMATED SYNTHESIS MODULE (ASM) FOR THE PRODUCTION OF OXYGEN-15 LABELED BUTANOL IS PROPOSED.

    SBC: CTI SERVICES, INC.            Topic: N/A

    THE DEVELOPMENT OF AN AUTOMATED SYNTHESIS MODULE (ASM) FOR THE PRODUCTION OF OXYGEN-15 LABELED BUTANOL IS PROPOSED. OXYGEN-15LABELED BUTANOL IS THE ""GOLD STANDARD'' FOR CEREBRAL BLOOD FLOW MEASUREMENT BUT BECAUSE OF THE SHORT HALF-LIFE OF OXYGEN-15 (2 MINUTES) THE SYNTHESIS MUST BE PERFORMED IN A RAPID AUTOMATED MODULE FOR WIDESPREAD UTILIZATION IN THE THE NEW ASM MODULE WILL EFFICIENTLY REMOVE T ...

    SBIR Phase I 1985 Department of Health and Human Services
  9. WE PROPOSE TO DEVELOP AN AUTOMATED CHEMISTRY SYSTEM TO WORK FROM THE TARGET OF THE CTI MEDICAL CYCLOTRON.

    SBC: CTI SERVICES, INC.            Topic: N/A

    WE PROPOSE TO DEVELOP AN AUTOMATED CHEMISTRY SYSTEM TO WORK FROM THE TARGET OF THE CTI MEDICAL CYCLOTRON. THE SYNTHESIS WILL BE 16-BETAMETHOXY-17-ALPHA-IODOVINYLESTRADIOL. THE MATERIAL HAS PROVEN TO BE ONE OF THE MOST ACTIVE STEROID RECEPTOR SITE AGENTS TO DATE AND SHOULD PROVE VALUABLE FOR THE DIFFERENTIATION OF STEROID-TREATABLE BREAST TUMORS FROM NONSTEROID-TREATABLE BREAST TUMORS. THE FUNDAMEN ...

    SBIR Phase I 1985 Department of Health and Human Services
  10. A NEW TWO-DIMENSIONAL POSITION ENCODER IS PROPOSED FOR PET WITH POSITION RESOLUTION BETTER THAN 3 MILLIMETERS.

    SBC: CTI SERVICES, INC.            Topic: N/A

    A NEW TWO-DIMENSIONAL POSITION ENCODER IS PROPOSED FOR PET WITH POSITION RESOLUTION BETTER THAN 3 MILLIMETERS. THE NEW DETECTOR INCLUDES 32 BISMUTH GERMANATE (BGO) SCINTILLATION CRYSTALS MOUNTED ON A LIGHT GUIDE. THE LIGHT GUIDE PROVIDES A SQUARE ROOT SEPARATION OF THE LIGHT DISTRIBUTION FROM EACH CRYSTAL. THE LIGHT FROM THE LIGHT GUIDE IS DETECTED BY TWO DUAL HAMAMATSU PHOTOMULTIPLIER TUBES (R154 ...

    SBIR Phase I 1985 Department of Health and Human Services

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