Award Data

Glycosaminoglycans (GAGs) are polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrix. More recently, changes in the content, size, and composition of GAGs have been found to play biological roles in disease processes as well. For example, chondroitin sulfate (CS) is the most abunda ...

THE GOAL OF THIS PROPOSAL IS TO PRODUCE AN ANALYTICAL DATABASE SYSTEM FOR GENETICISTS TO FACILITATE THE TASK OF COLLECTING, ORGANIZING, AND MAINTAINING DATA SPECIFIC TO THIS FIELD. MANY DISPARATE PROGRAMS ARE AVAILABLE FOR THE ANALYSIS OF GENETIC DATA, BUT MOST REQUIRE COMPUTING AND GENETIC ANALYSIS EXPERTISE FOR THEIR USE, AND ALL REQUIRE THE GENETICIST TO DIRECT THE ANALYSIS STRATEGY APPROPRIATE ...

A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS FOR THE DETECTION OF PATHOGENIC VIRUSES, BACTERIA, AND CELLS. DEVELOPMENT OF AN INTERFACIAL LIGHT-SCATTERING IMMUNOASSAY (ISI) IS PROPOSED. SURFACE IMMOBILIZED ANTIBODIES PROVIDE TARGET ORGANISM SPECIFICITY WHILE TOTAL INTERNAL REFLECTION-GENERATED INTERFACIAL LIGHT SCATTERING PROVIDES INTENSE, TARGET-SPECIFIC SIGNAL. S ...

A MULTICHANNEL TUBULAR DEVICE CONTAINING ULTRA-THIN WALLED TUBES, PERMEABLE TO O2 AND CO2, WILL BE DESIGNED AND FABRICATED FOR USE AS AN EXTRAPULMONARY BLOOD GAS EXCHANGE DEVICE. THE PRODUCT IS INTENDED TO BE INSERTED INTO THE SUBJECT'S VENA CAVAL SYSTEM, ENTERING INTO THE RIGHT COMMON FEMORAL VEIN AND EXITING FROM THE RIGHT EXTERNAL JUGULAR VEIN. OXYGEN IS PASSED THROUGH THE LUMINA OF THE HOLLOW ...

Project Summary Nerve injury can occur due to traumachronic compression or disease processes such as diabetes or tumors and have a tremendous socioeconomic impact from loss of work and healthcare costsThere is still a clinical need to improve recovery from nerve injuriesand a new nerve conduit drug delivery device that addresses this clinical need is the focus of the present proposalOur group has ...

ABSTRACTOtitis media or middle ear infections is a prevalent disease associated with early childhoodThe primary surgical intervention for persistent and recurring otitis media is insertion of ear tubestympanostomymyringotomy tubesThere are aboutear tubes placed annually in the United StatesA recognized risk with ear tubes is secondary infection or post operative otorrheaThe rate of secondary infec ...

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A TREATMENT OF HYDROPHILIC POLY(HYDROXYETHYL METHACRYLATE) CONTACT LENSES TO MINIMIZE IRREVERSIBLE PROTEIN ADSORPTION WILL BE TESTED. PROTEIN ADSORPTION ON LENSES NOT ONLY LEADS TO CLOUDING AND OPACITIES, BUT ALSO INDUCES WHAT APPEARS TO BE AN IMMUNE RESPONSE IN THE WEARER. THIS RESPONSE IS OBSERVED IN THE EARLY STAGES TO INCLUDE INCREASED MUCUS PRODUCTION, MILD ITCHING, DECREASED LENS TOLERANCE A ...

THE DETECTION AND CHARACTERIZATION OF PESTICIDES, INDUSTRIAL SOLVENTS, AND THEIR METABOLITES IN BODY FLUIDS AND TISSUES ARE IMPORTANT FOR EVALUATING THE POTENTIAL LONG-TERM HEALTH EFFECTS OF THE EXPOSED POPULATION. UNFORTUNATELY, ANALYTICAL METHODS PRESENTLY AVAILABLE ARE GENERALLY TEDIOUS, TIME-CONSUMING, COMPLEX OR NONSPECIFIC AND LACK REQUIRED SENSITIVITY. THIS STUDY WILL EVALUATE CAPILLARY SUP ...

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