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This application is based on ADT Pharmaceuticalsdiscoveries thatthe cGMP degrading phosphodiesterase isozymephosphodiesteraseAPDEis overexpressed during early stages of tumorigenesisgenetic knockdown of PDEresults in selective apoptosis of tumor cells by activating cGMP PKG signalingandsmall molecule inhibitors of PDEinduce apoptosis by PKG phosphorylation of oncogeniccateninthereby suppressing Tc ...

Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Nitor TherapeuticsIncNitorProject Summary Abstract The over arching commercial goal for this Nitor TherapeuticsIncNitorand DiscoveryBioMedIncDBMcollaboration is to discover and validate Stimulator of Interferon Genes orSTINGinhibitor ligands in a novel high throughput screeningHTSand validation based Critical Path of bioassaysAberr ...

AbstractThe overall goal of this study is to develop and demonstrate a novelpredictive in vitro organotypicD culture models of the blood brain barrierBBBderived from rodents for chemical toxicity screeningIn contrast with current Transwell based static and microfluidic assaysour commercially available SynBBB model enables real time visualization and quantitation of transport permeation under physi ...

Approximatelyof the population has unruptured cerebral aneurysmsapproximatelymillion people in the USAboutrupture per yearwith devastating consequencesAboutof patients with ruptured aneurysms dieandofwho survive have significant disabilitiesCoil embolization therapy is associated with a high rate of recurrenceFlow diverters are increasingly being used to cover the neck of the aneurysm providing mo ...

PROJECT SUMMARY The for profit small business concernTricorder Array Technologies LLCwill developin partnership with the University of Alabama at BirminghamSIDECAReSensing and Integrating Data for Environmental Conditions in Animal ResearchThis device will automate collection of relevant data that will enhance consistency in animal models used to study human health treatment researchOur innovative ...

Project Summary Abstract Oral vaccines have the potential to make a revolutionary improvement in the quality of life in developing countriesSince these vaccines can be administered by community health workers who are not trained medical personnelthe number of people who can be immunized in a short period of time is drastically increased while the cost per patient is significantly loweredOral vacci ...

PROJECT SUMMARYABSTRACT To datethe standard method to access a mouse tail vein is manual injectionbut its yield rate is poor in generalThis leads to multiple needle insertions associated with tissue damage and painBesidesfailure in tail vein injection leads to data lossand thereby more animals will be required to compensate itFinallythe dose variation induced by unreliable injection increases erro ...

Abstract The overall objective of this study is to develop a novelpredictive in vitro platform for studying physiological responses of endothelium mediated human cardiomyocytes toxicity to therapeuticsThe proposed effort specifically responds to NHLBI Small Business Topics of Special Interest HLSA critical in vivo component lacking in conventional models used for cardiac toxicity is the absence of ...

This project seeks to develop inhibitors of a novel pancreatic ductal adenocarcinomaPDACprotein targetPDAC remains one of the deadliest cancers with an average survival ofmonths for non resectable tumorsCurrentlya major obstacle in PDAC treatment is that the cells rapidly exhibit resistance to existing untargeted treatment regimens leaving patients with no further optionsStudies indicate that inhi ...

PROJECT SUMMARY Significance: Americaandapos;s health care system remains challenged by tens of billions of dollars of fraud and inefficiencies. Lost and stolen equipment cost about $4,000 per hospital bed, increasing to $8,000 when expenses incurred from out-of-place equipment are added. In addition, a 2017 report estimates $95 billion was lost to fraud, waste, abuse, and other improper payments ...