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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. DEVELOPMENT OF AN IMPROVED SMALL-DIAMETER VASCULAR GRAFT

    SBC: Biopolymers Inc            Topic: N/A

    FOR OVER 30 YEARS, A MAJOR GOAL OF VASCULAR SURGERY HAS BEEN TO IMPROVE BYPASS SURGERY THROUGH THE DEVELOPMENT OF AN IDEAL PROSTHETIC GRAFT. ALTHOUGH SAPHENOUS VEIN IS THE PREFERRED SUBSTRATE FOR OCCLUDED SMALL-TO-MEDIUM VEINS, FREQUENTLY IT IS UNAVAILABLE OR UNSUITABLE FOR A GREAT NUMBER OF PATIENTS WHO NEED THIS SURGERY. TWO OF THE PROBLEMS THAT HAVE IMPAIRED THE DEVELOPMENT OF SUCH A GRAFT ARE ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. AUTOMATED EQUIPMENT FOR DNA SEQUENCING

    SBC: Biotix            Topic: N/A

    BIOTIX PROPOSES TO DEVELOP SEVERAL PIECES OF INSTRUMENTATIONTHAT WILL SPEED THE PROCESS OF DNA SEQUENCING. THE APPROACHIS TO ASSESS THE FEASIBILITY OF AUTOMATING SEVERAL STEPS OF THE SEQUENCING PROCEDURE THAT ARE CURRENTLY ACCOMPLISHED MANUALLY. SPECIFIC PHASE I OBJECTIVES INCLUDE THE DEVELOPMENT OF PROTOTYPES FOR A UNIT THAT WILL AUTOMATE THE ACTUAL SEQUENCING REACTIONS AND A UNIT THAT WILL SEMIA ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. MULTIPURPOSE CLONING/SUBCLONING SYSTEM

    SBC: Biotix            Topic: N/A

    BIOTIX PROPOSES TO DEVELOP SYSTEMS FOR STABLY CLONING SMALL AND LARGE DNA FRAGMENTS THAT ARE ALSO OPTIMIZED FOR PRODUCING A SERIES OF OVERLAPPING SUBCLONES USING EITHER THESINGLE-STRANDED OR THE DOUBLE-STRANDED PROCEDURE. THE VECTORS WILL BE CONSTRUCTED FROM EXISTING VECTORS UTILIZING A POWERFUL NEW INSERTION TECHNIQUE. SUCCESS IN THE CONSTRUCTION OF THESE VECTOR SYSTEMS WILL LEAD TO THE DEVELOPME ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. AN AUTOMATED PHONE SYSTEM FOR HEALTH PROMOTION PROGRAMS

    SBC: Computers In Psychiatry/            Topic: N/A

    PREVENTIVE HEALTH PROGRAMS ARE LEAST EFFECTIVE IN TRACKING CLIENTS, IN FOLLOWING UP AND MAINTAINING THE LONG-TERM EFFECTS OF INTERVENTIONS, AND IN EVALUATING THEIR OUTCOME. THESE COMPONENTS OF PREVENTIVE PROGRAMS REQUIRE REGULAR CONTACT WITH LARGE NUMBERS OF INDIVIDUAL CLIENTS AND DEMAND THE GREATEST EFFORT ON THE PART OF THE PROVIDERS IN TERMS OF TIME SPENT CONTACTING CLIENTS AND IN MAINTAINING A ...

    SBIR Phase II 1987 Department of Health and Human Services
  5. LOW-COST FLOW-THROUGH ISOELECTRIC FOCUSING

    SBC: Focus Research            Topic: N/A

    THIS PROPOSAL WILL EVALUATE AND DEFINE THE USEFULNESS OF A NOVEL APPROACH FOR THE SEPARATION AND PURIFICATION OF BIOLOGICAL COMPONENTS. THIS APPROACH WILL BE A MODIFICATIONOF THE ISOELECTRIC FOCUSING (IEF) PROCEDURE. THE MODIFICATION UTILIZES PH GRADIENTS ESTABLISHED BY DIFFUSION ACROSS DIALYSIS MEMBRANES WHICH SEPARATE THE AMPHOLYTES FROMTHE SPECIES BEING FOCUSED. THE PROCEDURE HAS SEVERAL ADVANT ...

    SBIR Phase I 1987 Department of Health and Human Services
  6. AZAANTHRACENEDIONES AS ANTITUMOR AGENTS

    SBC: Humphrey Chemical Company            Topic: N/A

    THE OBJECTIVE OF THIS PROPOSAL IS AN INTEGRATION OF A CHEMICAL AND BIOLOGICAL APPROACH TO THE COMMERCIAL DEVELOPMENT OF A NEW HETEROCYCLIC ANTITUMOR AGENT. HUMPHREYCHEMICAL COMPANY PROPOSES TO SYNTHESIZE AND BIOLOGICALLY EVALUATE A SERIES OF AZAANTHRACENE-9,10-DIONES. THE GOAL IS THE COMMERCIALIZATION OF AN ANTITUMOR AGENT THAT LACKS THE INHERENT CARDIOTOXICITY CURRENTLY EXHIBITED BY ANTINEOPLASTI ...

    SBIR Phase I 1987 Department of Health and Human Services
  7. THE DEVELOPMENT OF AN IMPROVED IMPLANTABLE

    SBC: MicroStrain, Inc.            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO PRODUCE A MICRO-MINIATURE, FULLY IMPLANTABLE DISPLACEMENT SENSOR, CAPABLE OF CHRONIC IMPLANTATION IN VIVO. THE DEVICE WILL INCORPORATE SEVERAL NEW FEATURES THAT ENHANCE THE GENERAL USEFULNESS OF THE SENSOR. THE DEVICE IS BASED ON THE PRINCIPLE OF DETECTION OF THE PROXIMITY OF A MAGNET BY A HALL-EFFECT SENSOR. PHASEI OF THE STUDY IS DESIGNED TO (1) TEST AND IMPROVE TH ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. DEVELOPMENT OF A NEW CORNEAL AESTHESIOMETER AND NORMS

    SBC: Neurocommunication Research            Topic: N/A

    DURING PHASE I, THE CREATION OF A SAFE, VALID, PRECISE, RELIABLE, RESEARCH PROTOTYPE INSTRUMENT FOR TESTING THE SOMATOSENSATION OF CORNEA, SCLERA, CONJUNCTIVA, AND EYELID IS EXPECTED. THE SPECIFIC AIMS OF PHASE I ARE TO: (1) MODIFY THE EXISTING WEINSTEIN ORAL MICROAESTHESIOMETER TO CREATE A NEW INSTRUMENT, A CORNEAL MICROAESTHESIOMETER, FOR TESTING CORNEAL SOMATOSENSATION; (2) DEMONSTRATE VALIDITY ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. N/A

    SBC: Neurocommunication Research            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  10. MICROCOMPUTER-BASED SYSTEM FOR REMEDIATION OF DYSLEXIA

    SBC: Optimum Resource Inc.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services

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