Award Data

Bronchial asthma is a chronic respiratory disease that can be lethalAsthma is a global health problemAccording to the CDCin USAthere are currentlymillion asthma sufferers and this number is increasingHalf of the asthma patients have at least one hospitalization per yearwith an annual medical cost of $BTraditionallyasthma is treated during flare ups with prescribed inhaled corticosteriodsIn recent ...

The goal of this project is to fabricate a novel nanoscintillator photosensitizer complex for X ray excited photodynamic therapyXPDTHereina low dose of X raysltGyis used to excite scintillating nanoparticleswhich downconvert ionizing radiation to UV vis lightPhotosensitizers loaded onto the nanoscintillator complex absorb this UV vis emission and generate cytotoxic reactive oxygen speciesROSin the ...

Tumor Irradiation during cancer treatment induces clonogenic death that can be best assessed by colony forming assaysThese colony forming assays are laborious and never utilized in high throughput screeningHTSformatsWe propose to develop anintegrated platform for HTS clonogenic survival assayfor cancer drug screening as well as radiation effect modulation screeningNamedI PARTSIntegrated platform f ...

Project Summary/Abstract – The EPA maintains a Toxics Release Inventory of andgt;650 toxic chemicals that are disposed or released from andgt;20,000 industrial sites in the United States, while HHS and USDA maintain a list of over 60 select agents and toxicants that pose a severe risk to human, animal, and plant health. These compounds represent only a fraction of the known and unknown environme ...

PROJECT SUMMARYZika virus, an emerging flavivirus, is associated with severe clinical outcomes, including Guillain-Barré syndrome and birth defects. Transmission of Zika virus is primarily mosquito- borne. Mosquito salivary proteins are known to enhance infectivity and pathogenesis in Zika, dengue and West Nile viruses by modulating immune responses. This proposal seeks to develop a novel vaccine ...

SUMMARY The apelin receptorAPLNRagonist program project is seeking to discover an orally active small molecule drug to preserve and improve the heart s right ventricularRVfunction in patients suffering from pulmonary arterial hypertensionPAHa devastating disease with high morbidity and mortalityThere is compelling evidence that RV function is a major determinant of clinical outcomes in PAH patient ...

PROJECT SUMMARY Monotherapy regimens of poly adenosine diphosphateADPribose polymerase inhibitorPARPihave demonstrated clear efficacy in the clinic against metastatic solid tumorswith the greatest activity observed in homologous recombination deficient HRD cancersbut have limited activity against non HRD cancersAs suchthere is great interest in combining PARPiandapos s with other systemic therapie ...

Project Summary We propose to deliver a GALC pharmacological chaperone to restore enzyme activity for the treatment of Krabbe Disease caused by GALC deficiencyKrabbe disease is a rarefatal degenerative disorder which destroys myelin sheath of the nervous systemMost of the casesoccur in infants beforemonths of age and usually death occurs by ageyearsThe later onset patients usually die betweenandye ...

Abstract Sarcoidosis is a systemic disease with large unmet medical needand unknown causecharacterized by the formation of immune granulomas in various organsmainly the lungs and the lymphatic systemAboutof patients develop a chronic or progressive disease necessitating long term treatmentCurrent therapiesincluding the standard of caresystemic corticosteroidsdo not prolong survival and only have l ...

Abstract Complex and lengthy treatment regimens coupled with rising drug resistance underscore the urgent need for new and better drugs to treat tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis (Mtb). Current treatment regimens for drug resistant TB involve the use of costly, less effective, and toxic drugs that must be continued for up to 24 months. The work proposed here focu ...