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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SYNTHETIC VACCINES UTILIZING BACULOVIRUS POLYHEDRA

    SBC: American Biogenetic Scie Inc            Topic: N/A

    THE AIM OF THIS PROPOSAL IS THE ADAPTATION OF BACULOVIRUS FOR THE PRODUCTION OF SYNTHETIC VACCINES. LATE AFTER INFECTION, BACULOVIRUS-INFECTED CELLS PRODUCE PARACRYSTALLINE OCCLUSION BODIES THAT CONSIST PRIMARILY OF ASINGLE PROTEIN, POLYHEDRIN. AMERICAN BIOGENETIC SCIENCES, INC. INTENDS TO MODIFY THE POLYHEDRIN GENE OF AUTOGRAPHA CALIFORNICA TO GENERATE RECOMBINANT OCCULSION BODIES EXPOSING ANTIGE ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. IMPLANTABLE HOLLOW FIBER GLUCOSE SENSOR

    SBC: ASH ACCESS TECHNOLOGY, INC.            Topic: N/A

    ASH MEDICAL SYSTEMS, INC. IS DEVELOPING TWO CLOSELY RELATED DEVICES THAT WILL IMPROVE HOME AND HOSPITAL MONITORING OF GLUCOSE FOR DIABETICS. THE COMMON ELEMENT OF BOTH DEVICES IS A FIBER THAT IS IMPLANTED SUBCUTANEOUSLY. A NEGATIVE PRESSURE IS APPLIED TO THIS FIBER TO WITHDRAW TISSUE FLUID. IN THE HOSPITAL MODEL, THE FLUID WILL BE CONTINUOUSLY TRANSFERRED TO AN OPTICAL ANALYZER CURRENTLY BEING DEV ...

    SBIR Phase II 1987 Department of Health and Human Services
  3. A NEW SORBENT SYSTEM FOR HEMODIALYSIS TREATMENT

    SBC: ASH ACCESS TECHNOLOGY, INC.            Topic: N/A

    ASH MEDICAL SYSTEMS, INC. HAS DEVELOPED A NEW SORBENT-BASED,SINGLE-ACCESS HEMODIALYSIS MACHINE THAT IS SAFE, SIMPLE, AND PORTABLE. THE BIOLOGIC-HD CURRENTLY USES A PLATE DIALYZER TO ACTIVELY PUMP BLOOD WHILE DIALYZING THE BLOOD AND A REDY HISORB COLUMN TO REGENERATE DIALYSATE. PREVIOUS RESEARCH HAS PROVEN THAT A THICK SORBENT SUSPENSION CAN FLOWTHROUGH THE SCREEN SUPPORTS OF THE PLATE DIALYZER, RE ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. INDWELLING FISTULA ACCESS DEVICE (IFAD) FOR HEMODIALYSIS

    SBC: ASH ACCESS TECHNOLOGY, INC.            Topic: N/A

    EFFECTIVE HEMODIALYSIS REQUIRES A BLOOD FLOW OF 250 TO 300 ML/MINUTE. THE USUAL METHOD FOR OBTAINING THIS BLOOD ISTO PLACE TWO LARGE NEEDLES INTO A FISTULA (ARTERIALIZED VEIN) OR A GRAFT (PTFE CONDUIT BETWEEN ARTERY AND VEIN). BOTH NEEDLES ARE REMOVED AT THE END OF EACH TREATMENT. THE OBJECTIVE OF THIS PROPOSAL IS TO FURTHER DEVELOP AN INDWELLING FISTULA ACCESS DEVICE (IFAD) THAT CAN BE INSERTEDIN ...

    SBIR Phase I 1987 Department of Health and Human Services
  5. AUDIO MECHANICAL TRANSDUCER COMMUNICATION SYSTEM

    SBC: CAMTECH, INC.            Topic: N/A

    THE AUDIO MECHANICAL TRANSDUCER (AMT) COMMUNICATION SYSTEM WILL SIGNIFICANTLY IMPROVE THE ENVIRONMENT OF WORKERS IN HIGH-AMBIENT-NOISE CONDITIONS BY PROVIDING A NEW METHOD OF COMMUNICATING. THE SYSTEM WILL ATTACH DIRECTLY TO MOST FORMS OF HEARING PROTECTION WITHOUT MODIFICATION OF THE PROTECTOR. IT WILL BE LOW COST, PERMIT MULTIPLE AUDIO INPUTS, AND DEMONSTRATE MAN/MACHINE INTERFACE CAPABILITIES. ...

    SBIR Phase I 1987 Department of Health and Human Services
  6. AUDIO MECHANICAL TRANSDUCER COMMUNICATION SYSTEM

    SBC: CAMTECH, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  7. THE DEVELOPMENT OF AN IMPROVED IMPLANTABLE

    SBC: MicroStrain, Inc.            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO PRODUCE A MICRO-MINIATURE, FULLY IMPLANTABLE DISPLACEMENT SENSOR, CAPABLE OF CHRONIC IMPLANTATION IN VIVO. THE DEVICE WILL INCORPORATE SEVERAL NEW FEATURES THAT ENHANCE THE GENERAL USEFULNESS OF THE SENSOR. THE DEVICE IS BASED ON THE PRINCIPLE OF DETECTION OF THE PROXIMITY OF A MAGNET BY A HALL-EFFECT SENSOR. PHASEI OF THE STUDY IS DESIGNED TO (1) TEST AND IMPROVE TH ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. EXPERT RADIOLOGY ASSISTANT

    SBC: Xdata Corp.            Topic: N/A

    FEASIBILITY RESEARCH IS PROPOSED FOR THE DEVELOPMENT OF A COMPUTER-BASED EXPERT RADIOLOGY ASSISTANT (XRA) TO AID IN THE DIAGNOSIS OF BREAST CANCER. THE PROPOSED EXPERT SYSTEM HAS THE POTENTIAL TO ASSIST RADIOLOGISTS IN THE INTERPRETATION OF DIAGNOSTIC IMAGES AND CLINICAL DATA USING ARTIFICIAL INTELLIGENCE. THE SYSTEM WAS FORMED BY ENCODING IN THE COMPUTER SOFTWARE THE KNOWLEDGE OF HUMAN EXPERTS. T ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. N/A

    SBC: Xdata Corp.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  10. SUBPICOMOLE DETECTION OF PEPTIDES/AMINO ACIDS

    SBC: Bioanalytical Systems, Inc.            Topic: N/A

    THIS PROPOSAL IS TO STUDY THE SYNTHETIC METHODS TO INCORPORATE HIGH-SENSITIVITY ELECTROCHEMICALLY ACTIVE FUNCTIONAL GROUPS INTO AMINES, AMINO ACIDS AND PEPTIDES OF BIOLOGICAL ORIGIN. THE PURPOSE OF THIS DERIVATIZATION IS TO PERMIT THE QUANTITATIVE ANALYSIS OF PICOMOLE LEVELS OF THESE COMPOUNDS USING LIQUID CHROMATOGRAPHY COUPLED TO AN ELECTROCHEMICAL SENSOR. PHASE I OF THIS PROPOSAL IS TO STUDY: ( ...

    SBIR Phase II 1985 Department of Health and Human Services

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