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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A MINIATURIZED 6D POSITION LOCATOR FOR MEDICAL IMAGING

    SBC: ASCENSION TECHNOLOGY CORPORATION            Topic: N/A

    THE OBJECTIVE IS TO DEVELOP A MINIATURIZED SIX DEGREES-OF-FREEDOM (6D) TRACKING APPARATUS FOR USE WITH THREE DIMENSIONAL (3D) ULTRASOUND AND MEDICAL IMAGING EQUIPMENT. SUCH A TOOL COULD ENABLE CLINICIANS TO STUDY HUMAN ANATOMY AND BODILY FUNCTIONS IN THREE DIMENSIONS. IN PURSUIT OF THIS GOAL, RESEARCHERS AT THE UNIVERSITY OF WASHINGTON HAVE BUILT A PROBE FOR 3-D TRANSESOPHAGEAL ECHOCARDIOGRAPHY (T ...

    SBIR Phase II 1994 Department of Health and Human Services
  2. Rapid, Automated Detection System for PCR Products

    SBC: Bio-tek Instruments, Inc.            Topic: N/A

    There is presently a great deal of interest in defecting specific genetic mutations or variants thatcould provide information about an individual's predisposition to a wide variety of diseases, predict anindividual's sensitivity to specific chemicals or drugs, or be used as prognostic indicators for thetreatment of patients with diseases such as cancer. Despite the importance of monitoring such ge ...

    SBIR Phase I 1994 Department of Health and Human Services
  3. Biosensors for Neurotransmitter Detection

    SBC: Bio-tek Instruments, Inc.            Topic: N/A

    This proposal describes the design and testing of new enzyme-based amperometric sensors for the neurochemically important species, choline, acetylcholine and glutamate. In these devices, the electrical communication between the flavin redox centers of an oxidase and an electrode is achieved via a network of donor-acceptor relays chemically bound to a highly flexible polymer. Because the electron t ...

    SBIR Phase II 1994 Department of Health and Human Services
  4. Assay for In Vivo Activated Protein C (APC) Activity

    SBC: Haematologic Technologies, Inc.            Topic: N/A

    In the area of clinical coagulation research, much attention is focused on the molecular eventswhich occur before, during, and after anticoagulant and antithrombotic therapies. For purposes ofmonitoring the safety, efficacy and long-term effects of such therapies, there exist a number ofcommercially available assays to assess the progression of the procoagulant and fibrinolytic responses.For examp ...

    SBIR Phase I 1994 Department of Health and Human Services
  5. Specific Inhibitors of Activated Protein C

    SBC: Haematologic Technologies, Inc.            Topic: N/A

    Factors V and VIII are procofactors which are essential components of the blood coagulationprocess. Deficiency in either of these proteins is associated with severe bleeding disorders, hemophiliaand para-hemophilia. Deficiency states of these proteins can be caused by their proteolytic inactivationby Activated Protein C (APC), a natural anticoagulant enzyme. Therapeutic intervention in hemophilia- ...

    SBIR Phase I 1994 Department of Health and Human Services
  6. THE DEVELOPMENT OF AN IMPROVED IMPLANTABLE

    SBC: MicroStrain, Inc.            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO PRODUCE A MICRO-MINIATURE, FULLY IMPLANTABLE DISPLACEMENT SENSOR, CAPABLE OF CHRONIC IMPLANTATION IN VIVO. THE DEVICE WILL INCORPORATE SEVERAL NEW FEATURES THAT ENHANCE THE GENERAL USEFULNESS OF THE SENSOR. THE DEVICE IS BASED ON THE PRINCIPLE OF DETECTION OF THE PROXIMITY OF A MAGNET BY A HALL-EFFECT SENSOR. PHASEI OF THE STUDY IS DESIGNED TO (1) TEST AND IMPROVE TH ...

    SBIR Phase I 1987 Department of Health and Human Services
  7. DYSLEXIA AFFECTS MILLIONS OF CHILDREN AND ADULTS.

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: N/A

    DYSLEXIA AFFECTS MILLIONS OF CHILDREN AND ADULTS. THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP, TEST, AND MARKET SOFTWARE DESIGNED TO REMEDIATE DYSLEXIA. NO SUCH PRODUCT CURRENTLY EXISTS. DURING PHASE I, A PROTOTYPE READING PROGRAM WILL BE PRODUCED BASED ON INSTRUCTIONAL CONTENT SPECIFIED WITH CONSULTANTS MARION BLANK AND ISABELLE LIBERMAN, BOTH WELL-KNOWN RESEARCHERS IN THE PROCESSES INVOLVED IN R ...

    SBIR Phase I 1985 Department of Health and Human Services
  8. EPIDEMIOLOGIC AND CLINICAL STUDIES HAVE DOCUMENTED THE HIGH PREVALENCE OF LIGAMENTOUS TISSUE INJURY AMONG ATHLETES AND OTHER INDIVIDUALS ENGAGED IN VARIOUS SPORTING ACTIVITIES.

    SBC: Shelburne Laboratories, Inc.            Topic: N/A

    EPIDEMIOLOGIC AND CLINICAL STUDIES HAVE DOCUMENTED THE HIGH PREVALENCE OF LIGAMENTOUS TISSUE INJURY AMONG ATHLETES AND OTHER INDIVIDUALS ENGAGED IN VARIOUS SPORTING ACTIVITIES. TREATMENT OF THESE INJURIES BY AUGMENTING OR REPLACING INJURED TISSUE WITH OTHER TISSUE FROM THE BODY HAS NOT BEEN SUCCESSFUL. FOR THIS REASON, ATTENTION HAS SHIFTED TO DEVELOPMENT OF PROSTHETIC LIGAMENTS. A POTENTIAL CANDI ...

    SBIR Phase I 1985 Department of Health and Human Services

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