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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Preclinical evaluation of the anti-neuroinflammatory properties and pharmacokinetic profile of a novel Fyn kinase inhibitors

    SBC: PK Biosciences Corporation            Topic: 101

    ABSTRACTParkinsonandapos s diseasePDis a debilitating neurodegenerative disorder characterized mainly by the progressive loss of dopaminergic neurons in the substantia nigra pars compactaSNpcresulting in severe neurological deficitsThe existing approaches to PD treatment are focused mainly on alleviating motor symptoms by compensating for neurochemical deficitsbut such treatment fails to halt prog ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Quantitative Biomarkers for Monitoring Alcohol Abstinence

    SBC: BEHAVIORAL DIAGNOSTICS, INC.            Topic: 450

    Imagine a world where alcoholism can be assessed and monitored in the same way that we diagnose and monitor diabetes with a Hemoglobin A cHbA cIn a recent Phase II projectwhose subject collection has closedBehavioral Diagnostics has taken the first step to that better world by developing a droplet digital PCRddPCRpanel that is capable of identifying heavy alcohol consumption with an Receiver Opera ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. An Integrated Genetic-Epigenetic Tool for the Prediction of CHD Incidence in African-Americans

    SBC: Cardio Diagnostics, LLC            Topic: NHLBI

    ABSTRACTHeart disease is the leading cause of death in the United StatesCoronary heart diseaseCHDis the most common type of heart diseaseEvery yearmillions of Americans suffer otherwise preventable cardiac events resulting indeaths and $billion dollars of economic damage each yearThe prevalence of CHD varies by ethnicityNeverthelessfortunatelyCHD related morbidity and mortality can be prevented th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Receptor-targeted radionuclide therapy combined with immunotherapies to improve metastatic melanoma tumor response.

    SBC: VIEWPOINT MOLECULAR TARGETING, INC.            Topic: 102

    Melanoma incidence is rising faster than any other cancerSurgery can be curative at early stagesbut metastatic melanoma is typically fatalResponses to new targeted and immunotherapies can be remarkable in select casesbut low response ratesacquired resistanceand severe adverse side effectsparticularly for combination immunotherapieslimit long term quality of life for these patientsThusdespite what ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting SWELL1 Signaling to Treat Obesity-Induced Type 2 Diabetes

    SBC: Senseion, LLC            Topic: 200

    Project Summary Abstract TypediabetesT Dis characterized by both a loss of insulin sensitivity of target tissuesfatskeletal muscleliverand ultimatelyimpaired insulin secretion from the pancreaticcellWe have identified a novel SWELLmediated signaling pathway that regulates both insulin sensitivity and insulin secretionwhereby SWELLloss of function can both negatively regulate insulin signaling in t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Micro-Mechanical Insertion Tool withIntraoperative Real-Time Electrophysiological Sensing Control for Cochlear Implantation

    SBC: iotaMotion, Inc.            Topic: NIDCD

    Abstract: While the Cochlear Implant (CI) has traditionally been used to treat patients with severe to complete hearing loss, recent advances have now made the CI a treatment option for people with moderate hearing levels who previously did not qualify for a traditional CI. These hearing preservation approaches attempt to preserve the patientandapos;s residual hearing following CI surgery. However ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Mol: An Interactive Learning Platform to Address Difficult Concepts in Organic Chemistry

    SBC: Substrate Interactive, Inc.            Topic: 500

    Abstract Concepts of organic chemistry are central to medicine and pharmacology. However, organic chemistry represents a significant hurdle for science, technology, engineering, and mathematics students in pre-health tracks. Low exam scores and high failure rates result from the enormous amount of information, complex chemical structures and dynamics, and processes requiring creativity and spatial ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Neuroinformatics platform using machine learning and content-based image retrieval for neuroscience image data

    SBC: MICROBRIGHTFIELD, LLC            Topic: 101

    This project aims to develop NeuroManager™, an innovative neuroinformatics platform for advanced parsing, storing, aggregating, analyzing and sharing of complex neuroscience image data. A core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using Semantics (ICARUS), a novel, intelligent neuroimage curation system that will enable image retrieval based ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Artificial intelligence-enabled, real-time communication software for optimizing clinical decision making during the allocation, procurement, and transplantation of donated organs

    SBC: Healthtech Solutions, Inc.            Topic: NLM

    Project Abstract for HealthTech Solutions Kidney transplantation is a clinically effective and cost-effective treatment for patients suffering from end-stage renal disease (ESRD) and diabetes. Twenty-two patients die each day waiting for a transplant and 30% of all deaths in the US could be prevented by organ transplant. Despite the obvious clinical and cost-effective advantages of kidney transpla ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. An Automated Patient Chart Error Detection System for Radiation Therapy

    SBC: Infondrian LLC            Topic: 101

    Project Summary/Abstract Every year, approximately 1,200 severe mistreatments happen in radiation therapy. Radiation therapy lawsuits rank in the top third of all medical specialties with an average of $313,000 per claim settled or litigated. The current method for detecting treatment errors is by a weekly patient chart check, where each treatment record is manually reviewed on a weekly basis. Thi ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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