Award Data

Congestive heart failure (CHF) is the most common reason for hospitalization in the U.S., with over 1 million admissions per year. Patients admitted with CHF usually need IV diuretics to promote fluid removal. The readmission rate is high – over 20% by 30 days, and 30% by 90 days post-discharge. This also presents an enormous economic burden - hospitalizations account for a large percentage of t ...

Project SummaryThis SBIR Phase I project will investigate the technical feasibility of a microfabricated chip system for enabling on site or in fieldhighly sensitive analysis of volatile organic compoundsVOCsin aqueous samplesThe system consists of two chips in a tandem configurationThe first chip is designed to extract VOCs directly from water samplesThe extracted VOCs are concentrated in the sec ...

This project aims to develop NeuroManager™, an innovative neuroinformatics platform for advanced parsing, storing, aggregating, analyzing and sharing of complex neuroscience image data. A core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using Semantics (ICARUS), a novel, intelligent neuroimage curation system that will enable image retrieval based ...

SUMMARY ABSTRACT African Americans are disproportionately affected by chronic and end stage kidney diseasewhileof patients on dialysis are African Americanonlyof the U Spopulation is African AmericanOne factor contributing to this disparity is the high incidence of autoimmune diseaseespecially systemic lupus erythematosusSLEpresent in the African American populationLupus nephritis is a common comp ...

The current inability to effectively deliver corrective doses of lysosomal enzymes to key cells involved in cardiovascular and cerebrovascular disease remains a significant hurdle for rare lysosomal disordersLSDsuch as Fabry disease and other diseases with significant cardiovascular pathologiesBioStrategies LC is developing the plant lectin RTB as a carrier capable of expanding enzyme delivery toh ...

Project Summary Original Fast-Track Project SummaryCurrent bone grafting techniques for functional rehabilitation with dental implants have limitations – high-cost, difficulties with fixation and stabilization, insufficient bone regeneration, high morbidity using autogenous block grafts and prolonged healing of up to 9 months. Existing synthetic bone fillers cannot match defect shape and volume, ...

ABSTRACT The goal of this Fast-Track STTR project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that increases mobility; reduces agitation, use of sedative medications, and delirium; and exhibits high satisfaction and acceptability among hospital staff, family members, and patients. Older mechanically ventilated patients are often immobilize ...

DESCRIPTION (provided by applicant): Ultrasound is widely used for imaging of blood vessels because it is non-invasive, real-time, and relatively inexpensive. Reliable quantitative evaluation of blood vessels plays a pivotal role in cardiovascular disease diagnosis and follow-up intervention to avoid progression to life or limb-threatening stages. These studies require accurate vessel measureme ...

DESCRIPTION (provided by applicant): Food safety remains a critical issue for human health in our society. The food system in our nation is vulnerable to contamination from natural pathogens and from bio-terrorist attack. Current detection methods are inadequate due to the time-consuming and laboratory-centered approaches presently in use. Instruments for rapid on-site detection of pathogens in f ...

DESCRIPTION (provided by applicant): The broad, long term objective of this proposal is to overcome optical design, ergonomical, and cosmetic obstacles that stand in the way of innovative lens designs for low vision enhancement. Specifically, we have chosen to carry forward the work on field expansion for Homonymous Hemianopia proposed by Dr. Eli Peli of the Schepens Eye Research Institute. The d ...