Award Data

While CAR-T therapies have advanced in the clinic, there are still two specific issues using these breakthrough therapies for blood cancers: Durable responses in patients are only at 30-50% and Cytokine Release Syndrome occurs in 60-90% of treated patients. These limitations, for a drug that costs as much as $500,000, may cost an additional $250,000+ for treating adverse events leading to caution ...

This project aims to develop NeuroManager™, an innovative neuroinformatics platform for advanced parsing, storing, aggregating, analyzing and sharing of complex neuroscience image data. A core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using Semantics (ICARUS), a novel, intelligent neuroimage curation system that will enable image retrieval based ...

IsoPlexis proposes to deliver a novel multi-omic method for targeted profiling of both the TCR sequence and proteome from an array of 1000+ single cells. Specifically, we will deliver a single-cell, TCR sequencing and protein capture assay for identifying responsive antigen specific TCRs, and concurrently evaluate these T-cells for functional response to that antigen. The challenge remains to link ...

Although signal transduction inhibitors occasionally offer clinical benefit for cancer patients, signal flux emanating from oncogenes is often distributed through multiple pathways, potentially underlying the resistance which causes failure of most such inhibitors. Measuring signal flux through multiple pathways, in response to signal transduction inhibitors, may help uncover network inter- action ...

ABSTRACT The goal of this Fast-Track STTR project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that increases mobility; reduces agitation, use of sedative medications, and delirium; and exhibits high satisfaction and acceptability among hospital staff, family members, and patients. Older mechanically ventilated patients are often immobilize ...

DESCRIPTION (provided by applicant): This proposal requests SBIR Phase II support to complete and field test an Internet-based language intervention system designed to promote language development in preschool children with language disorders. Language delays are pervasive among school-age children. Early intervention is crucial since the consequences of language delay can be serious and cumulativ ...

DESCRIPTION (provided by applicant): Dental Unit Waterlines have come under increasing scrutiny as residents of biofilms which harbor and release bacteria and in some instances harmful pathogens. As a result ADA has pro actively recommended that the water delivered by dental equipment have 3 mg per liter) can remove all of the planktonic bacteria and reduce biofilm levels by 99.99%. This suggerts ...

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DESCRIPTION (provided by applicant): Freeze-drying is commonly employed to concentrate temperature-sensitive pharmaceuticals. Freeze-drying is expensive and causes product degradation. Osmotic distillation (OD) is a candidate for gentler and lower-cost concentration but has not been commercially developed because microporous membranes fail due to wet-out. In Phase I, Compact Membrane Systems (C ...

DESCRIPTION (provided by applicant): The broad, long term objective of this proposal is to overcome optical design, ergonomical, and cosmetic obstacles that stand in the way of innovative lens designs for low vision enhancement. Specifically, we have chosen to carry forward the work on field expansion for Homonymous Hemianopia proposed by Dr. Eli Peli of the Schepens Eye Research Institute. The d ...