Award Data

The goal of this SBIR is to provide proof of concept of Vetigenicscanine derived scFv phage display platform for rapidcost effective production of highly versatilecanine derived scFvsscFvs against CDCDand CTLAthree high valueimmunological molecules being targeted by antibody based strategies in human cancer immunotherapywill be isolatedSelected scFvs will be sequenced and binding affinities determ ...

History Maker VR is a playful virtual reality (VR) content-creation tool that allows students to embody historical characters in immersive settings, record performances featuring those characters, and share their performance files to demonstrate material mastery. History Maker VR is designed to scaffold creative storytelling, and to encourage embodied learning and for students to take pride in con ...

Camelid single domain antibody fragmentsVHHpossess a number of distinctive features including a small sizean elevated stabilityand an ability to recognize epitopes non accessible for conventional antibodiesBesides common research and immunotherapy applicationscamelid VHHs are also used as co crystallization chaperonesprotein aggregation controllers and enzyme activity tunersIn this proposalwe wish ...

Taenia solium is a parasite acquired by pigs and transmitted to humans by eating or mishandling raw or undercooked infected porkIncidences primarily occur in areas with subsistence farming practices such as sub Saharan AfricaLatin Americaand AsiaIt affectsmillion people globallyCases of cystercercosis have been seen in the US and Canada due to globalizationIngested Taeniasolium oncospheres can mig ...

Solid organ transplantation can be life savingHoweverimmunosuppression necessary to prevent rejection increases the incidence of cutaneous squamous cell carcinomacSCCfoldCurrent treatments for solid organ transplant recipientsSOTRsare largely surgicalwhich can be disfiguring and impact quality of lifeThere is a huge need for a safe and effective chemoprevention agent for cSCC in SOTRsThe RAF MEK E ...

PROJECT SUMMARY In pediatric cardiovascular surgery, no commercially available vascular conduit is capable of growing with the patient following implantation. This inability to grow with the patient is particularly relevant for newborns and young children because additional surgeries are required to replace the implanted conduit. In order to address this issue, PECA Labs has developed a novel card ...

Project SummaryDeep venous thrombosisDVTand secondary pulmonary embolismPEaffectof the population and cause approximatelydeaths annually in the USImmobility and lack of muscular activity is the primary risk factor for DVTan effect attributed to reduced venous flowAutopsy studies have identified the venous valve sinus in the leg as the site of origin for DVTbut a molecular and cellular mechanism fo ...

Project Summary Abstract Dravet Spectrum disorders resulting from SCN A loss of functionLOFmutations include febrile seizuresgeneralized epilepsy with febrile seizure plusGEFSand Dravet SyndromeDSin order of severityDS symptoms begin in infancy and lead to progressive developmental and behavioral impairments along with characteristic recurrent and varied seizuresIn many patientsseizures are resist ...

Project Summary AbstractRecentlythe NIH and various journals issued guidelines intended to increase rigor in biomedical scienceThe removal of bias through blinding was identified as a central means for improving rigorThe effects of unintentional bias can be easy to overlookand blinding procedures are often time consuming and tediousDue to this perceived lack of need and high effort requirementblin ...

PROJECT SUMMARY ABSTRACT Vocal fold paralysisVFPoccurs when the recurrent laryngeal nerveRLNis injuredmost commonly during surgery of the neckBilateral injury to the RLN can result in potentially life threatening airway obstruction and the need for tracheostomyThe RLN can regenerate some of its axonsbut in many patients with paralysis some form of intervention is required to correct the airway obs ...