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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Improving the Transfer of ERK siRNA Constructs Using Nanoporous Silica

    SBC: APOLLO SRI, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research suggests that APMS will be significantly more eff ...

    STTR Phase I 2007 Department of Health and Human Services
  2. A Global Test of Hemostatic Risk

    SBC: Haematologic Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Phase I funding for this project supported successful studies that were aimed at demonstrating the feasibility of developing an easy to use, global test in the arena of clinical hemostasis that would be sensitive to antithrombotic drugs, bleeding disorders and thrombotic pathologies. This test comprises a measurement of the rate of thrombin generation and/or to ...

    STTR Phase II 2007 Department of Health and Human Services
  3. Theory of Mind Software for Autism and other Communication Disorders

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Full participation in the human social milieu requires that one be able to understand that other people have their own goals, intentions, and beliefs (which may or may not be correct) - and that these epistemic states govern people's behavior. This form of awareness has been called Theory of Mind (ToM). Unfortunately, the development of ToM is severely delayed ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. 3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

    SBC: MICROBRIGHTFIELD, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogenesis of neurodegenerative and neuropsychiatric diseases. Methods in current practice are not conducive to high-throughput studies because they a ...

    SBIR Phase II 2007 Department of Health and Human Services
  5. Integrated Teleconferencing Unit For Home-Based Interactive Exercise For Elders

    SBC: MICRODESIGN CONSULTING, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Supervised group exercise has been shown to be an effective component for improving balance and preventing falls among elders who have suffered falls or exhibit a fear of falling due to frailty. In a Phase I SBIR study, we developed a model for conducting group exercise programs for elders in their homes via video- conferencing, called tele-based group exercise ...

    SBIR Phase II 2007 Department of Health and Human Services
  6. Automated Connective Tissue Torque Sensor

    SBC: STROMATEC, INC            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goal of this project is to establish the usefulness of needle torque measurements for the diagnosis and monitoring of connective tissue pathology associated with chronic musculoskeletal conditions treated by manual therapies. This project will combine technologies developed in our previous research and technological transfer programs which 1) show ...

    SBIR Phase I 2007 Department of Health and Human Services
  7. High Precision Bioassay Using Robotics and Statistics

    SBC: PRECISION BIOASSAY Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Abstract Cell culture bioassays are often laborious and imprecise even after substantial development efforts. These bioassays are used broadly in the biotechnology industry to measure protein or vaccine products in development and for lot release. Imprecise assays and slow assay development contribute to slow product development. Common practice in cell culture ...

    SBIR Phase II 2007 Department of Health and Human Services
  8. THE DEVELOPMENT OF AN IMPROVED IMPLANTABLE

    SBC: MicroStrain, Inc.            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO PRODUCE A MICRO-MINIATURE, FULLY IMPLANTABLE DISPLACEMENT SENSOR, CAPABLE OF CHRONIC IMPLANTATION IN VIVO. THE DEVICE WILL INCORPORATE SEVERAL NEW FEATURES THAT ENHANCE THE GENERAL USEFULNESS OF THE SENSOR. THE DEVICE IS BASED ON THE PRINCIPLE OF DETECTION OF THE PROXIMITY OF A MAGNET BY A HALL-EFFECT SENSOR. PHASEI OF THE STUDY IS DESIGNED TO (1) TEST AND IMPROVE TH ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. DYSLEXIA AFFECTS MILLIONS OF CHILDREN AND ADULTS.

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: N/A

    DYSLEXIA AFFECTS MILLIONS OF CHILDREN AND ADULTS. THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP, TEST, AND MARKET SOFTWARE DESIGNED TO REMEDIATE DYSLEXIA. NO SUCH PRODUCT CURRENTLY EXISTS. DURING PHASE I, A PROTOTYPE READING PROGRAM WILL BE PRODUCED BASED ON INSTRUCTIONAL CONTENT SPECIFIED WITH CONSULTANTS MARION BLANK AND ISABELLE LIBERMAN, BOTH WELL-KNOWN RESEARCHERS IN THE PROCESSES INVOLVED IN R ...

    SBIR Phase I 1985 Department of Health and Human Services
  10. EPIDEMIOLOGIC AND CLINICAL STUDIES HAVE DOCUMENTED THE HIGH PREVALENCE OF LIGAMENTOUS TISSUE INJURY AMONG ATHLETES AND OTHER INDIVIDUALS ENGAGED IN VARIOUS SPORTING ACTIVITIES.

    SBC: Shelburne Laboratories, Inc.            Topic: N/A

    EPIDEMIOLOGIC AND CLINICAL STUDIES HAVE DOCUMENTED THE HIGH PREVALENCE OF LIGAMENTOUS TISSUE INJURY AMONG ATHLETES AND OTHER INDIVIDUALS ENGAGED IN VARIOUS SPORTING ACTIVITIES. TREATMENT OF THESE INJURIES BY AUGMENTING OR REPLACING INJURED TISSUE WITH OTHER TISSUE FROM THE BODY HAS NOT BEEN SUCCESSFUL. FOR THIS REASON, ATTENTION HAS SHIFTED TO DEVELOPMENT OF PROSTHETIC LIGAMENTS. A POTENTIAL CANDI ...

    SBIR Phase I 1985 Department of Health and Human Services

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