Award Data

DESCRIPTION (provided by applicant): Phase I funding for this project supported successful studies that were aimed at demonstrating the feasibility of developing an easy to use, global test in the arena of clinical hemostasis that would be sensitive to antithrombotic drugs, bleeding disorders and thrombotic pathologies. This test comprises a measurement of the rate of thrombin generation and/or to ...

DESCRIPTION (provided by applicant): The long term goal of this project is to establish the usefulness of needle torque measurements for the diagnosis and monitoring of connective tissue pathology associated with chronic musculoskeletal conditions treated by manual therapies. This project will combine technologies developed in our previous research and technological transfer programs which 1) show ...

DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogenesis of neurodegenerative and neuropsychiatric diseases. Methods in current practice are not conducive to high-throughput studies because they a ...

DYSLEXIA AFFECTS MILLIONS OF CHILDREN AND ADULTS. THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP, TEST, AND MARKET SOFTWARE DESIGNED TO REMEDIATE DYSLEXIA. NO SUCH PRODUCT CURRENTLY EXISTS. DURING PHASE I, A PROTOTYPE READING PROGRAM WILL BE PRODUCED BASED ON INSTRUCTIONAL CONTENT SPECIFIED WITH CONSULTANTS MARION BLANK AND ISABELLE LIBERMAN, BOTH WELL-KNOWN RESEARCHERS IN THE PROCESSES INVOLVED IN R ...

EPIDEMIOLOGIC AND CLINICAL STUDIES HAVE DOCUMENTED THE HIGH PREVALENCE OF LIGAMENTOUS TISSUE INJURY AMONG ATHLETES AND OTHER INDIVIDUALS ENGAGED IN VARIOUS SPORTING ACTIVITIES. TREATMENT OF THESE INJURIES BY AUGMENTING OR REPLACING INJURED TISSUE WITH OTHER TISSUE FROM THE BODY HAS NOT BEEN SUCCESSFUL. FOR THIS REASON, ATTENTION HAS SHIFTED TO DEVELOPMENT OF PROSTHETIC LIGAMENTS. A POTENTIAL CANDI ...

DESCRIPTION (provided by applicant): Abstract Cell culture bioassays are often laborious and imprecise even after substantial development efforts. These bioassays are used broadly in the biotechnology industry to measure protein or vaccine products in development and for lot release. Imprecise assays and slow assay development contribute to slow product development. Common practice in cell culture ...

DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research suggests that APMS will be significantly more eff ...

DESCRIPTION (provided by applicant): Supervised group exercise has been shown to be an effective component for improving balance and preventing falls among elders who have suffered falls or exhibit a fear of falling due to frailty. In a Phase I SBIR study, we developed a model for conducting group exercise programs for elders in their homes via video- conferencing, called tele-based group exercise ...

This project aims to develop NeuroManager™, an innovative neuroinformatics platform for advanced parsing, storing, aggregating, analyzing and sharing of complex neuroscience image data. A core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using Semantics (ICARUS), a novel, intelligent neuroimage curation system that will enable image retrieval based ...

ABSTRACT The goal of this Fast-Track STTR project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that increases mobility; reduces agitation, use of sedative medications, and delirium; and exhibits high satisfaction and acceptability among hospital staff, family members, and patients. Older mechanically ventilated patients are often immobilize ...