Award Data

Improving our current ability to measure the shape of x-ray focusing mirrors is necessary to advance our knowledge of the atomic structure of many types of materials, especially for the latest diffraction-limited light sources within the DOE. X-ray studies at DOE national laboratories of the atomic structure of new materials, biological molecules, etc. are limited by the quality of the x-ray spot ...

This project aims to develop NeuroManager™, an innovative neuroinformatics platform for advanced parsing, storing, aggregating, analyzing and sharing of complex neuroscience image data. A core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using Semantics (ICARUS), a novel, intelligent neuroimage curation system that will enable image retrieval based ...

ABSTRACT The goal of this Fast-Track STTR project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that increases mobility; reduces agitation, use of sedative medications, and delirium; and exhibits high satisfaction and acceptability among hospital staff, family members, and patients. Older mechanically ventilated patients are often immobilize ...

In some areas of the USA and Europe, the installed capacity of renewable generation has reached a level at which wholesale energy prices can drop below zero due to overproduction relative to baseload capacity. The value of energy exported to the grid for behind-the-meter (BTM) systems is dropping, with policies in many states now promoting self-consumption of produced energy rather than net-meteri ...

Winter storms cause disruptions to transportation, the electrical grid, heating, business operation, emergency management services and on PV solar generation. Large storms can create dangerous, extreme conditions across entire regions and therefore the low-cost recovery of electricity supply and generation is of critical importance. After winter storms, PV arrays can be covered with snow for days ...

DESCRIPTION provided by applicant The goal of this project is to increase reading motivation engagement and proficiency in struggling readers Literacy is essential to academic success responsible citizenship and optimal health through the lifespan Research has shown that the motivation to read in the early grades is a significant predictor of later literacy outcoms an effect largely medi ...

DESCRIPTION provided by applicant As a highly used model organism Caenorhabditis elegans C elegans worms offer a wide range of possibilities for scientific research With advantages including but not limited to easy maintenance and handling forward and reverse genetic manipulability and a fully mapped nervous system connectome of neurons C elegans offer a high throughput alternati ...

Abstract It has become evident that the microvasculaturei emicroscopically small blood vesselsplays a critical role in the plasticity of the brain for fundamental processesineurogenesisiimigration of neuronal precursors to their final destination in the brainiiiaxonaldendritic and synaptic plasticity during brain developmentlearningaging and neurodegenerationandivrecovery from traumatic brain inju ...

Abstract This project aims to develop a novel systemSpines InvestigatorTMfor performing automated four dimensionalDquantitative analysis of changes in dendritic spine morphology on three dimensionalDmicroscopic images acquired with in vivo multiphoton fluorescence microscopy at different time pointsThe role of dendritic spines is one of the most active and important areas of neuroscience researchP ...

According to a 2014 study commissioned by the Department of Energy, hydropower from more than 3 million untapped streams in the United States could potentially generate 65 gigawatts of electricity and help to reduce greenhouse emissions and pollution. However, the development of hydropower has been limited by several obstacles, as described by the United States Geological Survey: most of the prime ...