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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. CONTRIBUTION OF SURFACE PROPERTIES TO ANTIBODY IMMOBILIZATION

    SBC: Midwest Research            Topic: N/A

    THE IMMOBILIZATION OF PROTEINS ON INSOLUBLE SURFACES IS IMPORTANT IN DIAGNOSTIC INSTRUMENTATION AND IN VIVO MONITOR-ING. IMPROVEMENTS IN THE SURFACE ANTIBODY INTERACTIONS SHOULD RESULT IN MORE EFFICIENT APPROACHES TO IMMUNO- DIAGNOSTICS. THIS WOULD BE ESPECIALLY USEFUL IN THE FIELD OF TUMOR MARKER DETECTION WHERE PANELS OF ANTIGENS MAY BE NEEDED FOR PROPER DIAGNOSIS. THIS RESEARCH IS THE DEVELOPME ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. SPUTTERED OXIDE FOR DENTAL CERAMIC-METAL BOND

    SBC: Midwest Research            Topic: N/A

    THE OBJECTIVE OF THE PROPOSED RESEARCH PROJECT IS TO INVESTIGATE THE USE OF A NOVEL, GRADIENT-COMPOSITION, SPUTTERED-OXIDE FILM FOR IMPROVING THE BONDING BETWEEN METALAND CERAMIC IN PORCELAIN-FUSED-TO-MENTAL DENTAL RESTORATIONS. THE PRESENT PROCESS UTILIZES A DISCRETE OXIDELAYER FORMED BY DIFFUSION AND AN ACCUMULATION OF OXIDE-FORMING ELEMENTS FROM THE BULK OF THE METAL CASTING TOTHE PORCELAIN INT ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. LARGE-SCALE PRODUCTION OF AVIAN MYELOBLASTOSIS VIRUS

    SBC: Molecular Biology Resources            Topic: N/A

    AVIAN MYELOBLASTOSIS VIRUS (AMV), A SOURCE OF REVERSE TRANSCRIPTASE FOR USE IN RECOMBINANT DNA WORK, IS CURRENTLY PRODUCED COMMERCIALLY FROM THE PLASMA OF LEUKEMIC CHICKS. PRODUCTION INVOLVES INOCULATION OF SEVERAL HUNDRED DAY-OLD CHICKS WITH AMV AND HARVEST OF VIRUS-CONTAINING BLOOD BY HEART PUNCTURE 7 TO 10 DAYS LATER. THE RESEARCH PROPOSED WILL INVESTIGATE THE FEASIBILITY OF COMMERCIAL-SCALE PR ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. QUANTITATION OF SERUM PROTEINS USING 2-D ELECTROPHORESIS

    SBC: The Kendrick Laboratorytory            Topic: N/A

    TWO-DIMENSIONAL (2-D) ELECTROPHORESIS IS THE MOST EFFECTIVE METHOD KNOWN FOR RESOLVING COMPLEX MIXTURES OF PROTEINS. AT PRESENT, HOWEVER, THE METHOD IS SELDOM USED FOR QUANTITATIONOF PROTEINS IN HUMAN SERUM BECAUSE OF THREE PROBLEMS: (1) SERUM ALBUMIN INTERFERES WITH THE RESOLUTION OF MOST OTHER SERUM PROTEINS; (2) LOSSES DUE TO THE METHOD ARE NOT EASILY MONITORED; AND (3) COMPUTER SOFTWARE FOR RO ...

    SBIR Phase II 1987 Department of Health and Human Services
  5. SELECTIVE EXPOSURE RADIOGRAPHY IS A TECHNIQUE IN WHICH A PATIENT-SPECIFIC DIGITAL-BEAM ATTENUATOR (DBA) IS PLACED BEFORE THE PATIENT TO OPTIMIZE THE DISTRIBUTION OF INCIDENT RADIATION.

    SBC: Lunar Radiation Corpon            Topic: N/A

    SELECTIVE EXPOSURE RADIOGRAPHY IS A TECHNIQUE IN WHICH A PATIENT-SPECIFIC DIGITAL-BEAM ATTENUATOR (DBA) IS PLACED BEFORE THE PATIENT TO OPTIMIZE THE DISTRIBUTION OF INCIDENT RADIATION. THE FILTER IS FABRICATED BY A PRINTER EQUIPPED WITH A CERIUM RIBBON. THE FILTER IS BASED ON TEST SHOT INFORMATION DIGITIZED FROM THE OUTPUT OF A DETECTOR BEHIND THE PATIENT. THE TECHNIQUE IS BEING DEVELOPED AT THE U ...

    SBIR Phase I 1985 Department of Health and Human Services
  6. GENERATION OF MAGNETIC RESONANCE IMAGES OF INTRACRANIAL AND EXTRACRANIAL CAROTID ARTERIAL LUMENS, TOGETHER WITH RELATED VOLUME BLOOD FLOW INFORMATION FOR EACH LUMEN, HAS POTENTIAL FOR PROVIDING A NONINVASIVE AND MORE DEFINITIVE TECHNIQUE FOR DIAGNOSIS OF

    SBC: Metriflow, Inc.            Topic: N/A

    GENERATION OF MAGNETIC RESONANCE IMAGES OF INTRACRANIAL AND EXTRACRANIAL CAROTID ARTERIAL LUMENS, TOGETHER WITH RELATED VOLUME BLOOD FLOW INFORMATION FOR EACH LUMEN, HAS POTENTIAL FOR PROVIDING A NONINVASIVE AND MORE DEFINITIVE TECHNIQUE FOR DIAGNOSIS OF INCIPIENT STROKE DUE TO ARTERIAL DISEASE THAN EITHER ULTRASOUND OR ANGIOGRAPHY. TO DEMONSTRATE THIS POTENTIAL, WE PROPOSE TO APPLY A SENSITIVE LI ...

    SBIR Phase I 1985 Department of Health and Human Services
  7. WE PROPOSE TO DEVELOP A COMPUTER SYSTEM FOR THE ELDERLY TO HELP MAINTAIN AND ENHANCE MEMORY CAPABILITIES.

    SBC: REHABILITATION TECHNOLOGY, INC.            Topic: N/A

    WE PROPOSE TO DEVELOP A COMPUTER SYSTEM FOR THE ELDERLY TO HELP MAINTAIN AND ENHANCE MEMORY CAPABILITIES. THE SYSTEM WILL USE THE FRAMEWORK OF REALITY ORIENTATION, I.E., STIMULATION AND REPETITIVE ORIENTATION TO TIME, PLACE, PERSON, AND DAILY ACTIVITIES, WITH FREQUENT ENCOURAGEMENT AND REWARD. THE FOCUS OF THE MATERIAL COVERED WILL BE ACTIVITIES OF DAILY LIVING. THE PURPOSE OF THIS SYSTEM IS TO HE ...

    SBIR Phase I 1985 Department of Health and Human Services
  8. TECHNIQUE FOR RESOLVING COMPLEX MIXTURES OF PROTEINS.

    SBC: The Kendrick Laboratorytory            Topic: N/A

    TECHNIQUE FOR RESOLVING COMPLEX MIXTURES OF PROTEINS. HOWEVER, THE METHOD HAS HAD LITTLE CLINICAL USE BECAUSE IT IS NOT QUANTITATIVE. THE WORK PROPOSED HERE IS DIRECTED TOWARD CAREFUL QUANTITATION, USING 2-D ELECTROPHORESIS, OF 6 TEST SERUM PROTEINS WHICH CAN BE PURCHASED AND ARE WELL RESOLVED ON A 2-D GEL. THE PROTEINS ALBUMIN, TRANSFERRIN, ALPHA-ANTITRYPSIN, APO-AL LIPOPROTEIN, IGG HEAVY CHAIN A ...

    SBIR Phase I 1985 Department of Health and Human Services
  9. QUANTITATION OF SERUM PROTEINS USING 2-D ELECTROPHORESIS

    SBC: The Kendrick Laboratorytory            Topic: N/A

    N/A

    SBIR Phase I 1985 Department of Health and Human Services

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