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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Take on Training with Attainment: A Universally-Designed Video Training App to Foster Independence at Work for Individuals with Intellectual Disabilities.

    SBC: ATTAINMENT CO., INC.            Topic: NA

    This project develops Take on Training by Attainment, an application (app) that provides comprehensive instruction to job coaches and direct service workers (DSWs) to increase the independence of individuals with disabilities, maximize their independence on the job site, achieve advancement, and promote sustained employment. The goal for Take on Training by Attainment is to research and develop a ...

    SBIR Phase I 2019 Department of Health and Human ServicesAdministration for Community Living
  2. Lysis-free extraction of biopharmaceuticals from the periplasm of Clean Genome E. coli

    SBC: SCARAB GENOMICS, LLC            Topic: NIAID

    Thirty percent of recombinant therapeutic proteins are made in Ecoli and include important vaccine components such as carrier proteinsFurtherburgeoning new immunotherapies that use proteins such as single chain antibodies and virus like particles are enjoying increasing successTo meet the production needs of these expanding areasScarab Genomics proposes to extend the versatility of its Clean Genom ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Custom-Fit Personal Sound Amplification Smartphone Application

    SBC: ASCENDING HEARING TECHNOLOGIES, LLC            Topic: NIDCD

    PROJECT SUMMARYPersonal sound amplification productsPSAPshave recently become available to the publicPSAPs serve a potentially important role in providing audibility of sounds for adults who have difficulty hearing in some daily living situationsbut may not be candidates for traditionalhigh amplification hearing aidsFewer thanof adults with hearing loss reporting use of hearing aidsciting high cos ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A novel asthma drug candidate targeting the GABAergic system in lung inflammation

    SBC: PANTHERICS INCORPORATED            Topic: NHLBI

    The proposed research will advance preclinical characterization and validation of a novel drug for asthmaA growing body of research has uncovered functional gamma amino butyric acid type A receptorGABAARsignaling in non neuronal cellsOur research has demonstrated that ligands activating GABAAR subtypes located on airway smooth muscle and immune cells reduce airway hyper responsivenessAHRand inflam ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Accelerated Minimally Invasive Brain Clot Evacuation Using Guided Drug Delivery

    SBC: InseRT            Topic: 105

    SignificanceWe propose to extend and customize inseRT MRI s Real Time MR image guided surgical platformoriginally developed for cerebral biopsy and direct injection cancer therapiesto overcome shortcomings in CT guidance of a promising new thrombolytic therapy for intracerebral hemorrhageICHICH is a devastating injury creating stroke like outcomes inpeople in the USA each yearDamage from mechanica ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of the High Throughput APT-SNAP Platform for Rapid Identification ofNuclease-Resistant RNA Aptamers against p53 Missense Mutations

    SBC: Proteovista LLC            Topic: 102

    Project Summary Development of the High Throughput APT SNAP Platform for Rapid Identificationof Nuclease Resistant RNA Aptamers against pMissense MutationsPIsChristopher LWarren and Mary SOzers Normal proteins are often mutated in cancergenerating dominant negative effects as well as gain of function activity that contribute to cancer development and to the inhibition of therapeutic responsesProte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Rapid Production of Regional and Disease Specific Human Astrocytes for CNS Drug Discovery

    SBC: BrainXell, Inc            Topic: 105

    Project Summary AbstractThe personalsocietaland economic burden that disorders of the central nervous systemCNSplace on the United States is tremendousFromthe FDA approved justnew drugs to treat CNS disorders covering the clinical areas of neurologypsychiatryand painThat averages to just three new chemical entitiesNEIsper yearwhile clinical trial failure rates for CNS drug development remain great ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Hydrogel-enabled self-assembled human brain organoids for developmental neurotoxicity applications

    SBC: STEM PHARM, INCORPORATED            Topic: NIEHS

    Project Summary AbstractThere is a well recognized need for more accurate and cost effective toxicology screening for therapeutic and environmental compoundsCurrent methods using cell cultures or animal models lack predictability and can be costlyRecent advances in the development of stem cell derived brain organoids have led to increasing interest in these models for neural toxicology screening a ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Online Thermoacoustic Range Verification Overlaying Treatment Spot onto Ultrasound Images for Synchrocyclotron Proton Therapy Systems

    SBC: ACOUSTIC RANGE ESTIMATES, LLC            Topic: 102

    Particle therapy is a technique for treating solid tumors that is potentially more precise than x ray radiation therapyCharged particles enter the patient at relativistic speedsdepositing increasingly more dose as they come to rest inside the patientX ray photon beams deliver an exponentially decaying dose along the beam pathdosing healthy tissue before and after the tumorWhen patient alignment is ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Discovery of cGAS Inhibitors for Interferon-Driven Autoimmune Diseases

    SBC: Bellbrook Labs, LLC            Topic: NIAID

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferonIFNresponse via activation of the STINGstimulator of interferon genesreceptorThe sensor for cytoplasmic nucleic acids was recently discovered to be cyclic GMP AMP synthasean enzyme that produces a unique cyclic dinucleotide second messengercGAMPthat serves as an agonist for the STI ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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